Galkin, Alexander

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selected publications

Effect of metformin on intact mitochondria from liver and brain: Concept revisited. European journal of pharmacology. 2022 Academic Article GET IT
Times cited: 3
Distribution of HLA-A, -B, -C, -DRB1, -DQB1, -DPB1 allele frequencies in patients with COVID-19 bilateral pneumonia in Russians, living in the Chelyabinsk region (Russia). Human immunology. 2022 Academic Article GET IT
Times cited: 1
How many molecules of mitochondrial complex I are in a cell?. Analytical biochemistry. 2022 Academic Article GET IT
Times cited: 1
Redox-dependent loss of flavin by mitochondria complex I is different in brain and heart. Redox biology. 2022 Academic Article GET IT
Times cited: 3
Antioxidant Role and Cardiolipin Remodeling by Redox-Activated Mitochondrial Ca²⁺-Independent Phospholipase A₂γ in the Brain. Antioxidants (Basel, Switzerland). 2022 Academic Article GET IT
Times cited: 2
Quantification of NADH:ubiquinone oxidoreductase (complex I) content in biological samples. The Journal of biological chemistry. 2021 Academic Article GET IT
Times cited: 5
ABO blood type analysis of the donors of convalescent plasma after COVID-19 infection in Chelyabinsk region, Russia. Vox sanguinis. 2021 Letter GET IT
Developmental window of vulnerability to white matter injury driven by sublethal intermittent hypoxemia. Pediatric research. 2021 Academic Article GET IT
Times cited: 2
Antioxidant Synergy of Mitochondrial Phospholipase PNPLA8/iPLA2γ with Fatty Acid-Conducting SLC25 Gene Family Transporters. Antioxidants (Basel, Switzerland). 2021 Review GET IT
Times cited: 7
Partial inhibition of mitochondrial complex I ameliorates Alzheimer's disease pathology and cognition in APP/PS1 female mice. Communications biology. 2021 Academic Article GET IT
Times cited: 24
Cyclophilin D-dependent oligodendrocyte mitochondrial ion leak contributes to neonatal white matter injury. The Journal of clinical investigation. 2020 Academic Article GET IT
Times cited: 8
Water route for proton pumping in mitochondrial complex I. Nature structural & molecular biology. 2020 Academic Article GET IT
Times cited: 1
Hypothermic oxygenated perfusion protects from mitochondrial injury before liver transplantation. EBioMedicine. 2020 Academic Article GET IT
Times cited: 68
Rats with a Human Mutation of NFU1 Develop Pulmonary Hypertension. American journal of respiratory cell and molecular biology. 2020 Academic Article GET IT
Times cited: 25
Measurement of mitochondrial H₂O₂ production under varying O₂ tensions. Methods in cell biology. 2020 Academic Article GET IT
Times cited: 2
Brain Ischemia/Reperfusion Injury and Mitochondrial Complex I Damage. Biochemistry. Biokhimiia. 2019 Review GET IT
Times cited: 42
Mechanism of mitochondrial complex I damage in brain ischemia/reperfusion injury. A hypothesis. Molecular and cellular neurosciences. 2019 Review GET IT
Times cited: 25
Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation. Cell metabolism. 2019 Academic Article GET IT
Times cited: 58
Redox-Dependent Loss of Flavin by Mitochondrial Complex I in Brain Ischemia/Reperfusion Injury. Antioxidants & redox signaling. 2019 Academic Article GET IT
Times cited: 34
Redox Signaling Through Compartmentalization of Reactive Oxygen Species: Implications for Health and Disease. Antioxidants & redox signaling. 2019 Editorial Article GET IT
Times cited: 10
Distal denervation in the SOD1 knockout mouse correlates with loss of mitochondria at the motor nerve terminal. Experimental neurology. 2019 Academic Article GET IT
Times cited: 4
The dependence of brain mitochondria reactive oxygen species production on oxygen level is linear, except when inhibited by antimycin A. Journal of neurochemistry. 2019 Academic Article GET IT
Times cited: 25
Attenuation of oxidative damage by targeting mitochondrial complex I in neonatal hypoxic-ischemic brain injury. Free radical biology & medicine. 2018 Academic Article GET IT
Times cited: 34
Critical Role of Flavin and Glutathione in Complex I-Mediated Bioenergetic Failure in Brain Ischemia/Reperfusion Injury. Stroke. 2018 Academic Article GET IT
Times cited: 57
Deactivation of mitochondrial complex I after hypoxia-ischemia in the immature brain. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2018 Academic Article GET IT
Times cited: 18
Correction: Early cerebellar deficits in mitochondrial biogenesis and respiratory chain complexes in the KIKO mouse model of Friedreich ataxia (doi: 10.1242/dmm.030502). Disease models & mechanisms. 2018 Academic Article GET IT
Krebs cycle metabolites and preferential succinate oxidation following neonatal hypoxic-ischemic brain injury in mice. Pediatric research. 2017 Academic Article GET IT
Times cited: 25
Early cerebellar deficits in mitochondrial biogenesis and respiratory chain complexes in the KIKO mouse model of Friedreich ataxia. Disease models & mechanisms. 2017 Academic Article GET IT
Times cited: 44
Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer. Proceedings of the National Academy of Sciences of the United States of America. 2017 Academic Article GET IT
Times cited: 408
Reverse electron transfer results in a loss of flavin from mitochondrial complex I: Potential mechanism for brain ischemia reperfusion injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2017 Academic Article GET IT
Times cited: 42
Distinct intracellular sAC-cAMP domains regulate ER Ca²⁺ signaling and OXPHOS function. Journal of cell science. 2017 Academic Article GET IT
Times cited: 21
HLA gene and haplotype frequencies in a Nagaybaks population from the Chelyabinsk Region (Russian South Urals). Human immunology. 2017 Academic Article GET IT
Modulation of the conformational state of mitochondrial complex I as a target for therapeutic intervention. Interface focus. 2017 Review GET IT
Times cited: 22
Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: Relevance to Alzheimer's disease. Biochimica et biophysica acta. Molecular basis of disease. 2017 Academic Article GET IT
Times cited: 37
Differential susceptibility of mitochondrial complex II to inhibition by oxaloacetate in brain and heart. Biochimica et biophysica acta. 2016 Academic Article GET IT
Times cited: 39
Ischemic A/D transition of mitochondrial complex I and its role in ROS generation. Biochimica et biophysica acta. 2016 Review GET IT
Times cited: 98
The Evaluation and Quantitation of Dihydrogen Metabolism Using Deuterium Isotope in Rats. PloS one. 2015 Academic Article GET IT
Times cited: 5
Effect of monovalent cations on the kinetics of hypoxic conformational change of mitochondrial complex I. Biochimica et biophysica acta. 2015 Academic Article GET IT
Times cited: 6
siRNA technology in kidney transplantation: current status and future potential. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. 2014 Review GET IT
Times cited: 12
Characterisation of the active/de-active transition of mitochondrial complex I. Biochimica et biophysica acta. 2014 Review GET IT
Times cited: 95
ND3, ND1 and 39kDa subunits are more exposed in the de-active form of bovine mitochondrial complex I. Biochimica et biophysica acta. 2014 Academic Article GET IT
Times cited: 37
Molecular mechanism and physiological role of active-deactive transition of mitochondrial complex I. Biochemical Society transactions. 2013 Academic Article GET IT
Times cited: 24
Conformational change of mitochondrial complex I increases ROS sensitivity during ischemia. Antioxidants & redox signaling. 2013 Academic Article GET IT
Times cited: 65
Conformation-specific crosslinking of mitochondrial complex I. FEBS letters. 2013 Academic Article GET IT
Times cited: 23
Preparation of highly coupled rat heart mitochondria. Journal of visualized experiments : JoVE. 2010 Academic Article GET IT
Times cited: 27
Lack of oxygen deactivates mitochondrial complex I: implications for ischemic injury?. The Journal of biological chemistry. 2009 Academic Article GET IT
Times cited: 103
Chapter 26 Measurement of superoxide formation by mitochondrial complex I of Yarrowia lipolytica. Methods in enzymology. 2009 Academic Article GET IT
Times cited: 13
Identification of the mitochondrial ND3 subunit as a structural component involved in the active/deactive enzyme transition of respiratory complex I. The Journal of biological chemistry. 2008 Academic Article GET IT
Times cited: 123
S-nitrosation of mitochondrial complex I depends on its structural conformation. The Journal of biological chemistry. 2007 Academic Article GET IT
Times cited: 106
Nitric oxide and hypoxia. Essays in biochemistry. 2007 Review GET IT
Times cited: 60
The proton pumping stoichiometry of purified mitochondrial complex I reconstituted into proteoliposomes. Biochimica et biophysica acta. 2006 Academic Article GET IT
Times cited: 105
The Redox-Bohr group associated with iron-sulfur cluster N2 of complex I. The Journal of biological chemistry. 2006 Academic Article GET IT
Times cited: 71
Proton pumping by complex I (NADH:ubiquinone oxidoreductase) from Yarrowia lipolytica reconstituted into proteoliposomes. Biochimica et biophysica acta. 2005 Academic Article GET IT
Times cited: 40
Structure-function relationships in mitochondrial complex I of the strictly aerobic yeast Yarrowia lipolytica. Biochemical Society transactions. 2005 Academic Article GET IT
Times cited: 16
Superoxide radical formation by pure complex I (NADH:ubiquinone oxidoreductase) from Yarrowia lipolytica. The Journal of biological chemistry. 2005 Academic Article GET IT
Times cited: 141
HDQ (1-hydroxy-2-dodecyl-4(1H)quinolone), a high affinity inhibitor for mitochondrial alternative NADH dehydrogenase: evidence for a ping-pong mechanism. The Journal of biological chemistry. 2004 Academic Article GET IT
Times cited: 57
H+/2e- stoichiometry of the nadh:ubiquinone reductase reaction catalyzed by submitochondrial particles. Biochemistry. Biokhimiia. 2001 Academic Article GET IT
Times cited: 18
-->H+/2e- stoichiometry in NADH-quinone reductase reactions catalyzed by bovine heart submitochondrial particles. FEBS letters. 1999 Academic Article GET IT
Times cited: 150

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Research

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Funding awarded

The role of FMN loss by mitochondrial Complex I in neonatal hypoxic-ischemic brain injury awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2022 - 2025
Metabolic origin of oxidative stress injury in brain ischemia/reperfusion awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2022 - 2024

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Background

education and training

Ph.D., Moscow State University (Russia) 2001
M.Sc., Moscow State University (Russia) 1996

Contact

full name

Alexander Galkin

primary email

alg2057@med.cornell.edu

VIVO Weill Cornell Medical College

Alexander Galkin Associate Professor of Research in Neuroscience

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email