Schaffer, Chris

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High fat diet worsens Alzheimer's disease-related behavioral abnormalities and neuropathology in APP/PS1 mice, but not by synergistically decreasing cerebral blood flow. Scientific reports. 2020 Academic Article GET IT
Times cited: 30
Preventing dementia by preventing stroke: The Berlin Manifesto. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2019 Review GET IT
Times cited: 159
Surgical preparations, labeling strategies, and optical techniques for cell-resolved, in vivo imaging in the mouse spinal cord. Experimental neurology. 2019 Review GET IT
Times cited: 15
Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer's disease mouse models. Nature neuroscience. 2019 Academic Article GET IT
Times cited: 208
Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function. Nature communications. 2018 Academic Article GET IT
Times cited: 77
Diverse Inflammatory Response After Cerebral Microbleeds Includes Coordinated Microglial Migration and Proliferation. Stroke. 2018 Academic Article GET IT
Times cited: 42
Mixing injector enables time-resolved crystallography with high hit rate at X-ray free electron lasers. Structural dynamics (Melville, N.Y.). 2016 Academic Article GET IT
Times cited: 272
TRAIL-coated leukocytes that prevent the bloodborne metastasis of prostate cancer. Journal of controlled release : official journal of the Controlled Release Society. 2015 Academic Article GET IT
Times cited: 59
Use of Tethered Enzymes as a Platform Technology for Rapid Analyte Detection. PloS one. 2015 Academic Article GET IT
Times cited: 7
Vascular contributions to cognitive impairment and dementia including Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2014 Review GET IT
Times cited: 407
A procedure for implanting a spinal chamber for longitudinal in vivo imaging of the mouse spinal cord. Journal of visualized experiments : JoVE. 2014 Academic Article GET IT
Times cited: 10
Constitutively active Notch4 receptor elicits brain arteriovenous malformations through enlargement of capillary-like vessels. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 70
Stalled cerebral capillary blood flow in mouse models of essential thrombocythemia and polycythemia vera revealed by in vivo two-photon imaging. Journal of thrombosis and haemostasis : JTH. 2014 Academic Article GET IT
Times cited: 31
TRAIL-coated leukocytes that kill cancer cells in the circulation. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 165
The challenge of connecting the dots in the B.R.A.I.N. Neuron. 2013 Academic Article GET IT
Times cited: 61
Optoporation and genetic manipulation of cells using femtosecond laser pulses. Biophysical journal. 2013 Academic Article GET IT
Times cited: 50
Big effects from tiny vessels: imaging the impact of microvascular clots and hemorrhages on the brain. Stroke. 2013 Review GET IT
Times cited: 15
Stimulus-evoked calcium transients in somatosensory cortex are temporarily inhibited by a nearby microhemorrhage. PloS one. 2013 Academic Article GET IT
Times cited: 30
Intracerebral haemorrhage associated with antithrombotic treatment: translational insights from experimental studies. The Lancet. Neurology. 2013 Review GET IT
Times cited: 50
Intravenous tPA therapy does not worsen acute intracerebral hemorrhage in mice. PloS one. 2013 Academic Article GET IT
Times cited: 16
Line-scanning particle image velocimetry: an optical approach for quantifying a wide range of blood flow speeds in live animals. PloS one. 2012 Academic Article GET IT
Times cited: 68
In vivo two-photon excited fluorescence microscopy reveals cardiac- and respiration-dependent pulsatile blood flow in cortical blood vessels in mice. American journal of physiology. Heart and circulatory physiology. 2012 Academic Article GET IT
Times cited: 101
Notch4 normalization reduces blood vessel size in arteriovenous malformations. Science translational medicine. 2012 Academic Article GET IT
Times cited: 71
Age-related intimal stiffening enhances endothelial permeability and leukocyte transmigration. Science translational medicine. 2011 Academic Article GET IT
Times cited: 275
Cortical microhemorrhages cause local inflammation but do not trigger widespread dendrite degeneration. PloS one. 2011 Academic Article GET IT
Times cited: 66
Real-time imaging of perivascular transport of nanoparticles during convection-enhanced delivery in the rat cortex. Annals of biomedical engineering. 2011 Academic Article GET IT
Times cited: 38
Preictal and ictal neurovascular and metabolic coupling surrounding a seizure focus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 Academic Article GET IT
Times cited: 91
Anticoagulation with the oral direct thrombin inhibitor dabigatran does not enlarge hematoma volume in experimental intracerebral hemorrhage. Circulation. 2011 Academic Article GET IT
Times cited: 75
Sub-surface, micrometer-scale incisions produced in rodent cortex using tightly-focused femtosecond laser pulses. Lasers in surgery and medicine. 2011 Academic Article GET IT
Times cited: 14
Occlusion of cortical ascending venules causes blood flow decreases, reversals in flow direction, and vessel dilation in upstream capillaries. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2011 Academic Article GET IT
Times cited: 64
Optically quantified cerebral blood flow. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2011 Comment GET IT
Times cited: 9
Estimating brain microvascular blood flows from partial two-photon microscopy data by computation with a circuit model. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2011 Academic Article GET IT
Times cited: 6
Limitations of collateral flow after occlusion of a single cortical penetrating arteriole. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2010 Academic Article GET IT
Times cited: 85
Two-photon microscopy-guided femtosecond-laser photoablation of avian cardiogenesis: noninvasive creation of localized heart defects. American journal of physiology. Heart and circulatory physiology. 2010 Academic Article GET IT
Times cited: 29
Optical tools to produce and study small strokes in animal models. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2010 Academic Article GET IT
Times cited: 3
Flexible microfluidic devices supported by biodegradable insertion scaffolds for convection-enhanced neural drug delivery. Biomedical microdevices. 2009 Academic Article GET IT
Times cited: 50
Targeted insult to subsurface cortical blood vessels using ultrashort laser pulses: three models of stroke. Nature methods. 2006 Academic Article GET IT
Times cited: 256
Two-photon imaging of cortical surface microvessels reveals a robust redistribution in blood flow after vascular occlusion. PLoS biology. 2006 Academic Article GET IT
Times cited: 286
All-optical histology using ultrashort laser pulses. Neuron. 2003 Academic Article GET IT
Times cited: 183
Dynamics of femtosecond laser-induced breakdown in water from femtoseconds to microseconds. Optics express. 2002 Academic Article GET IT
Times cited: 243
Micromachining bulk glass by use of femtosecond laser pulses with nanojoule energy. Optics letters. 2001 Academic Article GET IT
Minimally disruptive laser-induced breakdown in water. Optics letters. 1997 Academic Article GET IT
Times cited: 72

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Background

education and training

Ph.D., Harvard University 2001
B.S., University of Florida 1995

Contact

full name

Chris Schaffer

primary email

cs385@cornell.edu

VIVO Weill Cornell Medical College

Chris Schaffer Cornell University

Publications

selected publications

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Background

education and training

Contact

full name

primary email