Guo, Chun-Jun

Publications

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selected publications

Functional characterization of helminth-associated Clostridiales reveals covariates of Treg differentiation. bioRxiv : the preprint server for biology. 2023 Article GET IT
Increased Primary Bile Acids with Ileocolonic Resection Impact Ileal Inflammation and Gut Microbiota in Inflammatory Bowel Disease. Journal of Crohn's & colitis. 2023 Academic Article GET IT
Inulin fibre promotes microbiota-derived bile acids and type 2 inflammation. Nature. 2022 Academic Article GET IT
Times cited: 17
Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression. Nature communications. 2022 Academic Article GET IT
Times cited: 1
Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection. Cell. 2022 Academic Article GET IT
Times cited: 12
Genetic manipulation of gut microbes enables single-gene interrogation in a complex microbiome. Cell. 2022 Academic Article GET IT
Times cited: 27
Gut microbiota-derived metabolites confer protection against SARS-CoV-2 infection. Gut microbes. 2022 Academic Article GET IT
Times cited: 8
Transferable Immunoglobulin A-Coated Odoribacter splanchnicus in Responders to Fecal Microbiota Transplantation for Ulcerative Colitis Limits Colonic Inflammation. Gastroenterology. 2021 Academic Article GET IT
Times cited: 27
Immune activation kickstarts the gut microbiota. Cell host & microbe. 2021 Comment GET IT
Times cited: 2
Adherent-invasive E. coli metabolism of propanediol in Crohn's disease regulates phagocytes to drive intestinal inflammation. Cell host & microbe. 2021 Academic Article GET IT
Times cited: 36
Modulating microbiome metabolites in vivo. Science (New York, N.Y.). 2020 Academic Article GET IT
A metabolic pathway for bile acid dehydroxylation by the gut microbiome. Nature. 2020 Academic Article GET IT
Times cited: 160
Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells. Nature. 2020 Academic Article GET IT
Times cited: 307
Boosting polyketides production in cell factories: Shared target-pathway for pharmaceutical polyketides engineering. Synthetic and systems biotechnology. 2020 Academic Article GET IT
Times cited: 1
Depletion of microbiome-derived molecules in the host using Clostridium genetics. Science (New York, N.Y.). 2019 Academic Article GET IT
Times cited: 64
Microbial Transplantation With Human Gut Commensals Containing CutC Is Sufficient to Transmit Enhanced Platelet Reactivity and Thrombosis Potential. Circulation research. 2018 Academic Article GET IT
Times cited: 100
Genome-based deletion analysis in Aspergillus terreus reveals the acetylaranotin bis-thiomethyltransferase gene. Fungal genetics and biology : FG & B. 2018 Academic Article GET IT
Times cited: 6
Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases. Cell. 2017 Academic Article GET IT
Times cited: 149
Engineering Fungal Nonribosomal Peptide Synthetase-like Enzymes by Heterologous Expression and Domain Swapping. Organic letters. 2016 Academic Article GET IT
Times cited: 21
Discovery of McrA, a master regulator of Aspergillus secondary metabolism. Molecular microbiology. 2016 Academic Article GET IT
Times cited: 51
Microbial metabolomics in open microscale platforms. Nature communications. 2016 Academic Article GET IT
Times cited: 75
Characterization of the product of a nonribosomal peptide synthetase-like (NRPS-like) gene using the doxycycline dependent Tet-on system in Aspergillus terreus. Fungal genetics and biology : FG & B. 2016 Academic Article GET IT
Times cited: 22
Spatial regulation of a common precursor from two distinct genes generates metabolite diversity. Chemical science. 2015 Academic Article GET IT
Times cited: 28
Asperaculanes A and B, two sesquiterpenoids from the fungus Aspergillus aculeatus. Molecules (Basel, Switzerland). 2014 Academic Article GET IT
Times cited: 16
Recent advances in genome mining of secondary metabolites in Aspergillus terreus. Frontiers in microbiology. 2014 Review GET IT
Times cited: 54
Molecular genetic characterization of terreic acid pathway in Aspergillus terreus. Organic letters. 2014 Academic Article GET IT
Times cited: 27
Prototype of an intertwined secondary-metabolite supercluster. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 141
Application of an efficient gene targeting system linking secondary metabolites to their biosynthetic genes in Aspergillus terreus. Organic letters. 2013 Academic Article GET IT
Times cited: 47
Biosynthetic pathway for the epipolythiodioxopiperazine acetylaranotin in Aspergillus terreus revealed by genome-based deletion analysis. Journal of the American Chemical Society. 2013 Academic Article GET IT
Times cited: 72
Low-volume toolbox for the discovery of immunosuppressive fungal secondary metabolites. PLoS pathogens. 2013 Academic Article GET IT
Times cited: 55
Molecular genetic characterization of a cluster in A. terreus for biosynthesis of the meroterpenoid terretonin. Organic letters. 2012 Academic Article GET IT
Times cited: 69
Two separate gene clusters encode the biosynthetic pathway for the meroterpenoids austinol and dehydroaustinol in Aspergillus nidulans. Journal of the American Chemical Society. 2012 Academic Article GET IT
Times cited: 187
The synthesis and biological evaluation of 10-O-dialkylaminoethyl ginkgolide B as platelet-activating factor antagonist. Journal of Asian natural products research. 2008 Academic Article GET IT
Times cited: 3

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Research

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Funding awarded

Molecular Mechanisms behind microbiota regulation of host amino acid and glucose homeostasis awarded by National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator 2023 - 2028
Investigating molecular mechanisms behind gut bacterial transamination and IBD awarded by Kenneth Rainin Foundation Principal Investigator 2022 - 2024
An integrative and generalizable approach to modulate microbiota small molecules in the host awarded by National Institute of Child Health & Human Development Principal Investigator 2019 - 2024

Microbiota-derived metabolites and the regulation of host immunity and inflammation awarded by National Institute of Allergy & Infectious Diseases Co-Investigator 2022 - 2027
A randomized, placebo-controlled clinical trial examining the efficacy of Fecal Microbiota Transplantation (FMT) and subsequent dietary fiber in patients with moderate ulcerative colitis (MINDFUL) awarded by National Institute of Diabetes & Digestive & Kidney Diseases Co-Investigator 2021 - 2024

Dietary Regulation of Intestinal Inflammation and Repair awarded by National Institute of Diabetes & Digestive & Kidney Diseases Key Personnel 2022 - 2026

Viral Dark Matter In The Gut: Bacteriophage Mediated Effects On Intestinal Health awarded by Leona M. and Harry B. Helmsley Charitable Trust, The Principal Investigator Subaward 2020 - 2023

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Background

education and training

Ph.D., University of Southern California 2014
B.A., Fudan University (China) 2009

Contact

full name

Chun-Jun Guo

primary email

chg4001@med.cornell.edu

VIVO Weill Cornell Medical College

Chun-Jun Guo Assistant Professor of Immunology in Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email