Jagannath, Chinnaswamy

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A recombinant bovine adenoviral mucosal vaccine expressing mycobacterial antigen-85B generates robust protection against tuberculosis in mice. Cell reports. Medicine. 2021 Academic Article GET IT
Times cited: 12
Human monocyte-derived macrophage responses to M. tuberculosis differ by the host's tuberculosis, diabetes or obesity status, and are enhanced by rapamycin. Tuberculosis (Edinburgh, Scotland). 2020 Academic Article GET IT
Times cited: 5
Hyperglycemia and dyslipidemia: Reduced HLA-DR expression in monocyte subpopulations from diabetes patients. Human immunology. 2020 Academic Article GET IT
Times cited: 6
NOD2/RIG-I Activating Inarigivir Adjuvant Enhances the Efficacy of BCG Vaccine Against Tuberculosis in Mice. Frontiers in immunology. 2020 Academic Article GET IT
Times cited: 9
GM-CSF Dependent Differential Control of Mycobacterium tuberculosis Infection in Human and Mouse Macrophages: Is Macrophage Source of GM-CSF Critical to Tuberculosis Immunity?. Frontiers in immunology. 2020 Academic Article GET IT
Times cited: 12
Emerging Prevention and Treatment Strategies to Control COVID-19. Pathogens (Basel, Switzerland). 2020 Review GET IT
Times cited: 75
Human mesenchymal stem cell based intracellular dormancy model of Mycobacterium tuberculosis. Microbes and infection. 2020 Academic Article GET IT
Times cited: 6
Commentary: Bettering BCG: a tough task for a TB vaccine?. Frontiers in immunology. 2019 Comment GET IT
An autophagy-inducing and TLR-2 activating BCG vaccine induces a robust protection against tuberculosis in mice. NPJ vaccines. 2019 Academic Article GET IT
Times cited: 33
Macrophage heterogeneity and plasticity in tuberculosis. Journal of leukocyte biology. 2019 Review GET IT
Times cited: 54
Sphingosine kinase 1-associated autophagy differs between neurons and astrocytes. Cell death & disease. 2018 Academic Article GET IT
Times cited: 30
Pathogenesis and Animal Models of Post-Primary (Bronchogenic) Tuberculosis, A Review. Pathogens (Basel, Switzerland). 2018 Review GET IT
Times cited: 555
Supramolecular Peptide Nanofibers Engage Mechanisms of Autophagy in Antigen-Presenting Cells. ACS omega. 2017 Academic Article GET IT
Times cited: 146
Prophylactic Sublingual Immunization with Mycobacterium tuberculosis Subunit Vaccine Incorporating the Natural Killer T Cell Agonist Alpha-Galactosylceramide Enhances Protective Immunity to Limit Pulmonary and Extra-Pulmonary Bacterial Burden in Mice. Vaccines. 2017 Academic Article GET IT
Times cited: 99
Mesenchymal stem cells internalize Mycobacterium tuberculosis through scavenger receptors and restrict bacterial growth through autophagy. Scientific reports. 2017 Academic Article GET IT
Times cited: 38
Analysis of host-pathogen modulators of autophagy during Mycobacterium Tuberculosis infection and therapeutic repercussions. International reviews of immunology. 2017 Review GET IT
Times cited: 12
Pattern recognition receptors and coordinated cellular pathways involved in tuberculosis immunopathogenesis: Emerging concepts and perspectives. Molecular immunology. 2017 Review GET IT
Times cited: 32
Cord factor as an invisibility cloak? A hypothesis for asymptomatic TB persistence. Tuberculosis (Edinburgh, Scotland). 2016 Review GET IT
Times cited: 10
Emerging role of mesenchymal stem cells during tuberculosis: The fifth element in cell mediated immunity. Tuberculosis (Edinburgh, Scotland). 2016 Review GET IT
Times cited: 16
Pathogenesis of post primary tuberculosis: immunity and hypersensitivity in the development of cavities. Annals of clinical and laboratory science. 2014 Academic Article GET IT
Times cited: 54
BCG vaccine mediated reduction in the MHC-II expression of macrophages and dendritic cells is reversed by activation of Toll-like receptors 7 and 9. Cellular immunology. 2013 Academic Article GET IT
Times cited: 31
3rd Texas Tuberculosis Research Symposium: strengthening of TB research in the border state. Tuberculosis (Edinburgh, Scotland). 2013 Editorial Article GET IT
Harnessing of TLR-mediated autophagy to combat mycobacteria in macrophages. Tuberculosis (Edinburgh, Scotland). 2013 Academic Article GET IT
Times cited: 22
Autophagy regulates phagocytosis by modulating the expression of scavenger receptors. Immunity. 2013 Academic Article GET IT
Times cited: 143
Nitrite reductase NirBD is induced and plays an important role during in vitro dormancy of Mycobacterium tuberculosis. Journal of bacteriology. 2013 Academic Article GET IT
Times cited: 38
The fbpA/sapM double knock out strain of Mycobacterium tuberculosis is highly attenuated and immunogenic in macrophages. PloS one. 2012 Academic Article GET IT
Times cited: 36
Transient aggregation of ubiquitinated proteins is a cytosolic unfolded protein response to inflammation and endoplasmic reticulum stress. The Journal of biological chemistry. 2012 Academic Article GET IT
Times cited: 76
Rapamycin-induced enhancement of vaccine efficacy in mice. Methods in molecular biology (Clifton, N.J.). 2012 Academic Article GET IT
Times cited: 37
Uptake of silica and carbon nanotubes by human macrophages/monocytes induces activation of fibroblasts in vitro -- potential implication for pathogenesis of inflammation and fibrotic diseases. International journal of immunopathology and pharmacology. 2012 Academic Article GET IT
Times cited: 12
A defect in the synthesis of Interferon-γ by the T cells of Complement-C5 deficient mice leads to enhanced susceptibility for tuberculosis. Tuberculosis (Edinburgh, Scotland). 2011 Academic Article GET IT
Times cited: 15
OsmC proteins of Mycobacterium tuberculosis and Mycobacterium smegmatis protect against organic hydroperoxide stress. Tuberculosis (Edinburgh, Scotland). 2011 Academic Article GET IT
Times cited: 36
The ΔfbpA attenuated candidate vaccine from Mycobacterium tuberculosis, H37Rv primes for a stronger T-bet dependent Th1 immunity in mice. Tuberculosis (Edinburgh, Scotland). 2011 Academic Article GET IT
Times cited: 6
Cutting edge: Nicastrin and related components of γ-secretase generate a peptide epitope facilitating immune recognition of intracellular mycobacteria, through MHC class II-dependent priming of T cells. Journal of immunology (Baltimore, Md. : 1950). 2011 Academic Article GET IT
Times cited: 10
A Novel in vitro Human Macrophage Model to Study the Persistence of Mycobacterium tuberculosis Using Vitamin D(3) and Retinoic Acid Activated THP-1 Macrophages. Frontiers in microbiology. 2011 Academic Article GET IT
Times cited: 634
Anti-tuberculosis immunity induced in mice by vaccination with Mycobacterium smegmatis over-expressing Antigen 85B is due to the increased influx of IFNgamma-positive CD4 T cells into the lungs. Tuberculosis (Edinburgh, Scotland). 2009 Academic Article GET IT
Times cited: 8
Pulmonary surfactant and tuberculosis. Tuberculosis (Edinburgh, Scotland). 2009 Academic Article GET IT
Times cited: 36
Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells. Nature medicine. 2009 Academic Article GET IT
Times cited: 385
Trehalose 6,6'-dimycolate on the surface of Mycobacterium tuberculosis modulates surface marker expression for antigen presentation and costimulation in murine macrophages. Microbes and infection. 2008 Academic Article GET IT
Times cited: 46
The Delta fbpA mutant derived from Mycobacterium tuberculosis H37Rv has an enhanced susceptibility to intracellular antimicrobial oxidative mechanisms, undergoes limited phagosome maturation and activates macrophages and dendritic cells. Cellular microbiology. 2008 Academic Article GET IT
Times cited: 53
Granulocyte-macrophage colony stimulating factor-mediated innate responses in tuberculosis. Tuberculosis (Edinburgh, Scotland). 2007 Academic Article GET IT
Times cited: 56
Complement C5a anaphylatoxin is an innate determinant of dendritic cell-induced Th1 immunity to Mycobacterium bovis BCG infection in mice. Journal of leukocyte biology. 2007 Academic Article GET IT
Times cited: 29
Pathology of postprimary tuberculosis in humans and mice: contradiction of long-held beliefs. Tuberculosis (Edinburgh, Scotland). 2007 Review GET IT
Times cited: 146
The reduced bactericidal function of complement C5-deficient murine macrophages is associated with defects in the synthesis and delivery of reactive oxygen radicals to mycobacterial phagosomes. Journal of immunology (Baltimore, Md. : 1950). 2006 Academic Article GET IT
Times cited: 31
Processing and presentation of a mycobacterial antigen 85B epitope by murine macrophages is dependent on the phagosomal acquisition of vacuolar proton ATPase and in situ activation of cathepsin D. Journal of immunology (Baltimore, Md. : 1950). 2006 Academic Article GET IT
Times cited: 61
Modulation of Mycobacterium tuberculosis proliferation by MtrA, an essential two-component response regulator. Molecular microbiology. 2006 Academic Article GET IT
Times cited: 129
Trehalose 6,6'-dimycolate and lipid in the pathogenesis of caseating granulomas of tuberculosis in mice. The American journal of pathology. 2006 Academic Article GET IT
Times cited: 125
Multiple roles of cord factor in the pathogenesis of primary, secondary, and cavitary tuberculosis, including a revised description of the pathology of secondary disease. Annals of clinical and laboratory science. 2006 Review GET IT
Times cited: 160
Methionine sulfoxide reductase A (MsrA) deficiency affects the survival of Mycobacterium smegmatis within macrophages. Journal of bacteriology. 2004 Academic Article GET IT
Times cited: 69
Hypersusceptibility of A/J mice to tuberculosis is in part due to a deficiency of the fifth complement component (C5). Scandinavian journal of immunology. 2000 Academic Article GET IT
Times cited: 50
Cytokine mRNA expression and serum cortisol evaluation during murine lung inflammation induced by Mycobacterium tuberculosis. Combinatorial chemistry & high throughput screening. 2000 Academic Article GET IT
Times cited: 14
Effect of poloxamer CRL-1072 on drug uptake and nitric-oxide-mediated killing of Mycobacterium avium by macrophages. Immunopharmacology. 2000 Academic Article GET IT
Times cited: 10
Activity of poloxamer CRL-1072 against drug-sensitive and resistant strains of Mycobacterium tuberculosis in macrophages and in mice. International journal of antimicrobial agents. 2000 Academic Article GET IT
Times cited: 15
Identification of viable and non-viable Mycobacterium tuberculosis in mouse organs by directed RT-PCR for antigen 85B mRNA. Microbial pathogenesis. 2000 Academic Article GET IT
Times cited: 48
Apoptosis in mycobacterium tuberculosis infection in mice exhibiting varied immunopathology. The Journal of pathology. 2000 Academic Article GET IT
Times cited: 42
Relationship of survival, organism containment, and granuloma formation in acute murine tuberculosis. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 1999 Academic Article GET IT
Times cited: 50
Gas chromatographic/mass spectrometric identification and quantification of aniline after extraction from serum and derivatization with 4-carbethoxyhexafluorobutyryl chloride, a new derivative. Therapeutic drug monitoring. 1999 Academic Article GET IT
Times cited: 5
CRL-1072 enhances antimycobacterial activity of human macrophages through interleukin-8. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 1999 Academic Article GET IT
Times cited: 17
Significantly improved oral uptake of amikacin in FVB mice in the presence of CRL-1605 copolymer. Life sciences. 1999 Academic Article GET IT
Times cited: 26
Induction of nitric oxide in human monocytes and monocyte cell lines by Mycobacterium tuberculosis. Nitric oxide : biology and chemistry. 1998 Academic Article GET IT
Times cited: 89
Use of nonionic block copolymers in vaccines and therapeutics. Critical reviews in therapeutic drug carrier systems. 1998 Review GET IT
Times cited: 43
Immunohistochemical study of the expression of human groEL-stress protein in human nervous tissue. The Indian journal of medical research. 1996 Academic Article GET IT
Times cited: 1
Activities of poloxamer CRL8131 against Mycobacterium tuberculosis in vitro and in vivo. Antimicrobial agents and chemotherapy. 1995 Academic Article GET IT
Times cited: 31
Chemotherapeutic activity of clofazimine and its analogues against Mycobacterium tuberculosis. In vitro, intracellular, and in vivo studies. American journal of respiratory and critical care medicine. 1995 Academic Article GET IT
Times cited: 82
Enhancement of drug susceptibility of multi-drug resistant strains of Mycobacterium tuberculosis by ethambutol and dimethyl sulphoxide. The Journal of antimicrobial chemotherapy. 1995 Academic Article GET IT
Times cited: 27

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Background

education and training

Ph.D., University of Madras (India) 1984
M.Sc., Karnataka University (India) 1977
B.Sc., Bangalore University (India) 1972

Contact

full name

Chinnaswamy Jagannath

VIVO Weill Cornell Medical College

Chinnaswamy Jagannath Professor of Pathology and Laboratory Medicine

Publications

selected publications

Background

education and training

Contact

full name