Gibson, Gary E.

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Selective NADH communication from α-ketoglutarate dehydrogenase to mitochondrial transhydrogenase prevents reactive oxygen species formation under reducing conditions in the heart. Basic research in cardiology. 2020 Academic Article GET IT
Times cited: 20
Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy. Human molecular genetics. 2018 Academic Article GET IT
Times cited: 45
Mild metabolic perturbations alter succinylation of mitochondrial proteins. Journal of neuroscience research. 2017 Academic Article GET IT
Times cited: 21
Mitochondria/metabolic reprogramming in the formation of neurons from peripheral cells: Cause or consequence and the implications to their utility. Neurochemistry international. 2017 Review GET IT
Times cited: 6
Reductions in the mitochondrial enzyme α-ketoglutarate dehydrogenase complex in neurodegenerative disease - beneficial or detrimental?. Journal of neurochemistry. 2016 Academic Article GET IT
Times cited: 19
Novel Metabolic Abnormalities in the Tricarboxylic Acid Cycle in Peripheral Cells From Huntington's Disease Patients. PloS one. 2016 Academic Article GET IT
Times cited: 23
Mild mitochondrial metabolic deficits by α-ketoglutarate dehydrogenase inhibition cause prominent changes in intracellular autophagic signaling: Potential role in the pathobiology of Alzheimer's disease. Neurochemistry international. 2016 Academic Article GET IT
Times cited: 17
Abnormalities in the tricarboxylic Acid cycle in Huntington disease and in a Huntington disease mouse model. Journal of neuropathology and experimental neurology. 2015 Academic Article GET IT
Times cited: 34
Alpha-ketoglutarate dehydrogenase complex-dependent succinylation of proteins in neurons and neuronal cell lines. Journal of neurochemistry. 2015 Academic Article GET IT
Times cited: 78
Impaired mitochondrial energy metabolism as a novel risk factor for selective onset and progression of dementia in oldest-old subjects. Neuropsychiatric disease and treatment. 2015 Academic Article GET IT
Times cited: 18
The RNA-binding protein HuR is essential for the B cell antibody response. Nature immunology. 2015 Academic Article GET IT
Times cited: 101
Interactions of endoplasmic reticulum and mitochondria Ca(2+) stores with capacitative calcium entry. Metabolic brain disease. 2014 Academic Article GET IT
Times cited: 8
The negative impact of α-ketoglutarate dehydrogenase complex deficiency on matrix substrate-level phosphorylation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2013 Academic Article GET IT
Times cited: 43
Deficits in the mitochondrial enzyme α-ketoglutarate dehydrogenase lead to Alzheimer's disease-like calcium dysregulation. Neurobiology of aging. 2011 Academic Article GET IT
Times cited: 46
Up-regulation of the mitochondrial malate dehydrogenase by oxidative stress is mediated by miR-743a. Journal of neurochemistry. 2011 Academic Article GET IT
Times cited: 69
Inactivation and reactivation of the mitochondrial α-ketoglutarate dehydrogenase complex. The Journal of biological chemistry. 2011 Academic Article GET IT
Times cited: 56
Brain [U-13 C]glucose metabolism in mice with decreased α-ketoglutarate dehydrogenase complex activity. Journal of neuroscience research. 2011 Academic Article GET IT
Times cited: 15
Abnormalities in the tricarboxylic acid (TCA) cycle in the brains of schizophrenia patients. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2010 Academic Article GET IT
Times cited: 66
Thiamine and oxidants interact to modify cellular calcium stores. Neurochemical research. 2010 Academic Article GET IT
Times cited: 20
A mitocentric view of Alzheimer's disease suggests multi-faceted treatments. Journal of Alzheimer's disease : JAD. 2010 Review GET IT
Times cited: 90
Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria. The American journal of pathology. 2009 Academic Article GET IT
Times cited: 280
Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases. Biochimica et biophysica acta. 2009 Review GET IT
Times cited: 200
Mice deficient in dihydrolipoyl succinyl transferase show increased vulnerability to mitochondrial toxins. Neurobiology of disease. 2009 Academic Article GET IT
Times cited: 20
Mitochondrial dihydrolipoyl succinyltransferase deficiency accelerates amyloid pathology and memory deficit in a transgenic mouse model of amyloid deposition. Free radical biology & medicine. 2009 Academic Article GET IT
Times cited: 57
The role of glia, mitochondria, and the immune system in glaucoma. Investigative ophthalmology & visual science. 2009 Conference Paper GET IT
Times cited: 124
Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease. Neurochemistry international. 2008 Academic Article GET IT
Times cited: 405
Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model. Neurobiology of aging. 2008 Academic Article GET IT
Times cited: 107
Influence of mitochondrial enzyme deficiency on adult neurogenesis in mouse models of neurodegenerative diseases. Neuroscience. 2008 Academic Article GET IT
Times cited: 59
Translocation of amyloid precursor protein C-terminal fragment(s) to the nucleus precedes neuronal death due to thiamine deficiency-induced mild impairment of oxidative metabolism. Neurochemical research. 2008 Academic Article GET IT
Times cited: 16
Novel functions of the alpha-ketoglutarate dehydrogenase complex may mediate diverse oxidant-induced changes in mitochondrial enzymes associated with Alzheimer's disease. Biochimica et biophysica acta. 2007 Academic Article GET IT
Times cited: 50
Oxidative stress and transcriptional regulation in Alzheimer disease. Alzheimer disease and associated disorders. 2007 Review GET IT
Times cited: 133
Thiamine-dependent processes and treatment strategies in neurodegeneration. Antioxidants & redox signaling. 2007 Review GET IT
Times cited: 79
Responses of the mitochondrial alpha-ketoglutarate dehydrogenase complex to thiamine deficiency may contribute to regional selective vulnerability. Neurochemistry international. 2007 Academic Article GET IT
Times cited: 37
Enzyme-catalyzed side reactions with molecular oxygen may contribute to cell signaling and neurodegenerative diseases. Neurochemical research. 2007 Review GET IT
Times cited: 41
Changes in inflammatory processes associated with selective vulnerability following mild impairment of oxidative metabolism. Neurobiology of disease. 2007 Academic Article GET IT
Times cited: 50
Cisplatin-induced toxicity is associated with platinum deposition in mouse kidney mitochondria in vivo and with selective inactivation of the alpha-ketoglutarate dehydrogenase complex in LLC-PK1 cells. Biochemistry. 2006 Academic Article GET IT
Times cited: 41
Peripheral inflammatory mechanisms modulate microglial activation in response to mild impairment of oxidative metabolism. Neurochemistry international. 2006 Academic Article GET IT
Times cited: 22
Inhibitors of the alpha-ketoglutarate dehydrogenase complex alter [1-13C]glucose and [U-13C]glutamate metabolism in cerebellar granule neurons. Journal of neuroscience research. 2006 Academic Article GET IT
Times cited: 48
Cellular mitochondrial heterogeneity in cultured astrocytes as demonstrated by immunogold labeling of alpha-ketoglutarate dehydrogenase. Glia. 2006 Academic Article GET IT
Times cited: 42
Modification of endoplasmic reticulum Ca2+ stores by select oxidants produces changes reminiscent of those in cells from patients with Alzheimer disease. Free radical biology & medicine. 2005 Academic Article GET IT
Times cited: 18
Mitochondrial aconitase is a transglutaminase 2 substrate: transglutamination is a probable mechanism contributing to high-molecular-weight aggregates of aconitase and loss of aconitase activity in Huntington disease brain. Neurochemical research. 2005 Academic Article GET IT
Times cited: 44
Phosphonate analogues of alpha-ketoglutarate inhibit the activity of the alpha-ketoglutarate dehydrogenase complex isolated from brain and in cultured cells. Biochemistry. 2005 Academic Article GET IT
Times cited: 68
CD40-CD40L interactions promote neuronal death in a model of neurodegeneration due to mild impairment of oxidative metabolism. Neurochemistry international. 2005 Academic Article GET IT
Times cited: 26
CD40L deletion delays neuronal death in a model of neurodegeneration due to mild impairment of oxidative metabolism. Journal of neuroimmunology. 2005 Academic Article GET IT
Times cited: 14
Mitochondrial function in fibroblasts with aging in culture and/or Alzheimer's disease. Neurobiology of aging. 2005 Academic Article GET IT
Times cited: 29
Transglutaminase activity is present in highly purified nonsynaptosomal mouse brain and liver mitochondria. Biochemistry. 2005 Academic Article GET IT
Times cited: 48
Mitochondrial abnormalities in Alzheimer brain: mechanistic implications. Annals of neurology. 2005 Academic Article GET IT
Times cited: 446
Oxidative stress in Alzheimer's disease. Neurobiology of aging. 2005 Comment GET IT
Times cited: 90
Reduction in the E2k subunit of the alpha-ketoglutarate dehydrogenase complex has effects independent of complex activity. The Journal of biological chemistry. 2005 Academic Article GET IT
Times cited: 33
Inhibition of the alpha-ketoglutarate dehydrogenase complex by the myeloperoxidase products, hypochlorous acid and mono-N-chloramine. Journal of neurochemistry. 2005 Academic Article GET IT
Times cited: 46
Tricarboxylic acid cycle enzymes following thiamine deficiency. Neurochemistry international. 2004 Academic Article GET IT
Times cited: 58
alpha-keto-beta-methyl-n-valeric acid diminishes reactive oxygen species and alters endoplasmic reticulum Ca(2+) stores. Free radical biology & medicine. 2004 Academic Article GET IT
Times cited: 25
Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3-nitropropionic acid neurotoxicity. Journal of neurochemistry. 2004 Academic Article GET IT
Times cited: 79
Mitochondrial heterogeneity within and between different cell types. Neurochemical research. 2004 Academic Article GET IT
Times cited: 19
Mitochondrial enzymes in schizophrenia. Journal of molecular neuroscience : MN. 2004 Academic Article GET IT
Times cited: 39
Oxidative stress increases internal calcium stores and reduces a key mitochondrial enzyme. Biochimica et biophysica acta. 2002 Academic Article GET IT
Times cited: 43
Dichloroacetate exerts therapeutic effects in transgenic mouse models of Huntington's disease. Annals of neurology. 2001 Academic Article GET IT
Times cited: 64
Low mutational burden of individual acquired mitochondrial DNA mutations in brain. Genomics. 2001 Academic Article GET IT
Times cited: 30
Dietary restriction attenuates the neuronal loss, induction of heme oxygenase-1 and blood-brain barrier breakdown induced by impaired oxidative metabolism. Brain research. 2000 Academic Article GET IT
Times cited: 42
Vascular factors are critical in selective neuronal loss in an animal model of impaired oxidative metabolism. Journal of neuropathology and experimental neurology. 2000 Academic Article GET IT
Times cited: 40
Frontal lobe dysfunction in progressive supranuclear palsy: evidence for oxidative stress and mitochondrial impairment. Journal of neurochemistry. 2000 Academic Article GET IT
Times cited: 89
The alpha-ketoglutarate dehydrogenase complex in neurodegeneration. Neurochemistry international. 2000 Review GET IT
Times cited: 171
Metabolic impairment elicits brain cell type-selective changes in oxidative stress and cell death in culture. Journal of neurochemistry. 2000 Academic Article GET IT
Times cited: 25
Quantitative alpha-ketoglutarate dehydrogenase activity staining in brain sections and in cultured cells. Analytical biochemistry. 2000 Academic Article GET IT
Times cited: 25
Oxidative stress is associated with region-specific neuronal death during thiamine deficiency. Journal of neuropathology and experimental neurology. 1999 Academic Article GET IT
Times cited: 107
Metabolic impairment induces oxidative stress, compromises inflammatory responses, and inactivates a key mitochondrial enzyme in microglia. Journal of neurochemistry. 1999 Academic Article GET IT
Times cited: 119
Cultures of astrocytes and microglia express interleukin 18. Brain research. Molecular brain research. 1999 Academic Article GET IT
Times cited: 164
Protein-bound acrolein: a novel marker of oxidative stress in Alzheimer's disease. Journal of neurochemistry. 1999 Academic Article GET IT
Times cited: 346
Induction of nitric oxide synthase and microglial responses precede selective cell death induced by chronic impairment of oxidative metabolism. The American journal of pathology. 1998 Academic Article GET IT
Times cited: 85
Immunochemical characterization of the deficiency of the alpha-ketoglutarate dehydrogenase complex in thiamine-deficient rat brain. Journal of neurochemistry. 1998 Academic Article GET IT
Times cited: 39
Thiamine deficiency alters APP but not presenilin-1 immunoreactivity in vulnerable brain regions. Neuroreport. 1997 Academic Article GET IT
Times cited: 9
Novel neuritic clusters with accumulations of amyloid precursor protein and amyloid precursor-like protein 2 immunoreactivity in brain regions damaged by thiamine deficiency. The American journal of pathology. 1996 Academic Article GET IT
Times cited: 55
Regional reductions of transketolase in thiamine-deficient rat brain. Journal of neurochemistry. 1996 Academic Article GET IT
Times cited: 21
The role of signal transduction systems in mediating cell density dependent changes in tyrosine hydroxylase gene expression. Brain research. Molecular brain research. 1995 Academic Article GET IT
Times cited: 13
Blood-brain barrier abnormalities in vulnerable brain regions during thiamine deficiency. Experimental neurology. 1995 Academic Article GET IT
Accumulation of amyloid precursor protein-like immunoreactivity in rat brain in response to thiamine deficiency. Brain research. 1995 Academic Article GET IT
Times cited: 52
Heterogeneous expression of transketolase in rat brain. Journal of neurochemistry. 1995 Academic Article GET IT
Times cited: 20
Distribution of the alpha-ketoglutarate dehydrogenase complex in rat brain. The Journal of comparative neurology. 1994 Academic Article GET IT
Times cited: 45
Aging and the brain. Current opinion in neurology. 1994 Review GET IT
Times cited: 22
Selective enrichment of cholinergic neurons with the alpha-ketoglutarate dehydrogenase complex in rat brain. Neuroscience letters. 1994 Academic Article GET IT
Times cited: 12

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Background

education and training

Ph.D., Cornell University 1973
B.S., University of Wyoming 1968

Contact

full name

Gary E. Gibson

primary email

ggibson@med.cornell.edu

VIVO Weill Cornell Medical College

Gary E. Gibson Professor of Neuroscience

Publications

selected publications

Background

education and training

Contact

full name

primary email