Scandura, Joseph M

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MANIFEST: Pelabresib in Combination With Ruxolitinib for Janus Kinase Inhibitor Treatment-Naïve Myelofibrosis. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2023 Academic Article GET IT
Splenomegaly (SPML) in polycythemia vera (PV): its clinical significance and its relation to symptoms, post-polycythemic myelofibrosis (PPMF) and survival. Leukemia. 2022 Academic Article GET IT
Hematopoietic fitness of JAK2V617F myeloproliferative neoplasms is linked to clinical outcome. Blood advances. 2022 Academic Article GET IT
Times cited: 2
PRC2-Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1-Targeted Therapy via Enhanced Viral Mimicry. Cancer discovery. 2022 Academic Article GET IT
Times cited: 7
Expression of ENaC subunits in epithelia. The Journal of general physiology. 2022 Academic Article GET IT
Excess mortality in younger patients with myeloproliferative neoplasms. Leukemia & lymphoma. 2022 Letter GET IT
Times cited: 2
Defining disease modification in myelofibrosis in the era of targeted therapy. Cancer. 2022 Review GET IT
Times cited: 11
Normal life expectancy for polycythemia vera (PV) patients is possible. Leukemia. 2021 Academic Article GET IT
Times cited: 9
Reversal of emphysema by restoration of pulmonary endothelial cells. The Journal of experimental medicine. 2021 Academic Article GET IT
Times cited: 20
Androgen receptor variant shows heterogeneous expression in prostate cancer according to differentiation stage. Communications biology. 2021 Academic Article GET IT
Times cited: 3
Interferon-alpha for treating polycythemia vera yields improved myelofibrosis-free and overall survival. Leukemia. 2021 Academic Article GET IT
Times cited: 38
Prevalence and risk factors for Pulmonary Hypertension associated with chronic Myeloproliferative Neoplasms. European journal of haematology. 2020 Review GET IT
Times cited: 3
Hepcidin Is Essential for Alveolar Macrophage Function and Is Disrupted by Smoke in a Murine Chronic Obstructive Pulmonary Disease Model. Journal of immunology (Baltimore, Md. : 1950). 2020 Academic Article GET IT
Times cited: 10
Extracting and classifying diagnosis dates from clinical notes: A case study. Journal of biomedical informatics. 2020 Academic Article GET IT
Times cited: 6
Megakaryocyte TGFβ1 partitions erythropoiesis into immature progenitor/stem cells and maturing precursors. Blood. 2020 Academic Article GET IT
Times cited: 8
Ruxolitinib can cause weight gain by blocking leptin signaling in the brain via JAK2/STAT3. Blood. 2020 Letter GET IT
Times cited: 14
Correction: An alternative retinoic acid-responsive Stra6 promoter regulated in response to retinol deficiency. The Journal of biological chemistry. 2020 Academic Article GET IT
Incremental Utility of Right Ventricular Dysfunction in Patients With Myeloproliferative Neoplasm-Associated Pulmonary Hypertension. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography. 2019 Academic Article GET IT
Times cited: 9
Disease progression in myeloproliferative neoplasms: comparing patients in accelerated phase with those in chronic phase with increased blasts (<10%) or with other types of disease progression. Haematologica. 2019 Letter GET IT
Times cited: 8
Somatic mutations and cell identity linked by Genotyping of Transcriptomes. Nature. 2019 Academic Article GET IT
Times cited: 129
Adoptive Immunotherapy with Cord Blood for the Treatment of Refractory Acute Myelogenous Leukemia: Feasibility, Safety, and Preliminary Outcomes. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2018 Academic Article GET IT
Times cited: 3
Lessons Learned in the Development of a Computable Phenotype for Response in Myeloproliferative Neoplasms. IEEE International Conference on Healthcare Informatics. IEEE International Conference on Healthcare Informatics. 2018 Academic Article GET IT
Times cited: 2
Phase I trial of plerixafor combined with decitabine in newly diagnosed older patients with acute myeloid leukemia. Haematologica. 2018 Academic Article GET IT
Times cited: 29
CD25 expression and outcomes in older patients with acute myelogenous leukemia treated with plerixafor and decitabine. Leukemia & lymphoma. 2017 Academic Article GET IT
Times cited: 10
Conversion of adult endothelium to immunocompetent haematopoietic stem cells. Nature. 2017 Academic Article GET IT
Times cited: 144
Sox17 drives functional engraftment of endothelium converted from non-vascular cells. Nature communications. 2017 Academic Article GET IT
Times cited: 15
Molecular Checkpoint Decisions Made by Subverted Vascular Niche Transform Indolent Tumor Cells into Chemoresistant Cancer Stem Cells. Cancer cell. 2016 Academic Article GET IT
Times cited: 82
Phase I Study of Epigenetic Priming with Azacitidine Prior to Standard Neoadjuvant Chemotherapy for Patients with Resectable Gastric and Esophageal Adenocarcinoma: Evidence of Tumor Hypomethylation as an Indicator of Major Histopathologic Response. Clinical cancer research : an official journal of the American Association for Cancer Research. 2016 Academic Article GET IT
Times cited: 43
Transplantation of Endothelial Cells to Mitigate Acute and Chronic Radiation Injury to Vital Organs. Radiation research. 2016 Review GET IT
Times cited: 15
KRAS AND THE REALITY OF PERSONALIZED MEDICINE IN NON-SMALL CELL LUNG CANCER. Molecular medicine (Cambridge, Mass.). 2016 Academic Article GET IT
Times cited: 14
Allogeneic Transplantation for Patients With Advanced Myelofibrosis: Splenomegaly and High Serum LDH are Adverse Risk Factors for Successful Engraftment. Clinical lymphoma, myeloma & leukemia. 2016 Academic Article GET IT
Times cited: 12
Cutting the brakes on hematopoietic regeneration by blocking TGFβ to limit chemotherapy-induced myelosuppression. Molecular & cellular oncology. 2015 Review GET IT
Times cited: 208
An alternative retinoic acid-responsive Stra6 promoter regulated in response to retinol deficiency. The Journal of biological chemistry. 2014 Academic Article GET IT
Times cited: 22
Activation of the vascular niche supports leukemic progression and resistance to chemotherapy. Experimental hematology. 2014 Academic Article GET IT
Times cited: 45
Reprogramming human endothelial cells to haematopoietic cells requires vascular induction. Nature. 2014 Academic Article GET IT
Times cited: 174
Angiocrine factors deployed by tumor vascular niche induce B cell lymphoma invasiveness and chemoresistance. Cancer cell. 2014 Academic Article GET IT
Times cited: 169
The Rad50 hook domain regulates DNA damage signaling and tumorigenesis. Genes & development. 2014 Academic Article GET IT
Times cited: 37
[TGFβ contribution to hematopoietic regeneration after myelosuppressive chemotherapy]. Medecine sciences : M/S. 2013 Article GET IT
A phase I study of CPX-351 in combination with busulfan and fludarabine conditioning and allogeneic stem cell transplantation in adult patients with refractory acute leukemia. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2013 Academic Article GET IT
Times cited: 14
TGFβ restores hematopoietic homeostasis after myelosuppressive chemotherapy. The Journal of experimental medicine. 2013 Academic Article GET IT
Times cited: 71
Decitabine in patients with newly diagnosed and relapsed acute myeloid leukemia. Leukemia & lymphoma. 2013 Academic Article GET IT
Times cited: 126
RARγ is essential for retinoic acid induced chromatin remodeling and transcriptional activation in embryonic stem cells. Journal of cell science. 2012 Academic Article GET IT
Times cited: 49
Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer. Nature medicine. 2012 Academic Article GET IT
Times cited: 164
Development of a vascular niche platform for expansion of repopulating human cord blood stem and progenitor cells. Blood. 2012 Academic Article GET IT
Times cited: 77
Imatinib resistance and microcytic erythrocytosis in a KitV558Δ;T669I/+ gatekeeper-mutant mouse model of gastrointestinal stromal tumor. Proceedings of the National Academy of Sciences of the United States of America. 2012 Academic Article GET IT
Times cited: 26
Are low-intensity induction strategies better for older patients with acute myeloid leukemia?. Leukemia research. 2012 Academic Article GET IT
Times cited: 8
Frequent alterations and epigenetic silencing of differentiation pathway genes in structurally rearranged liposarcomas. Cancer discovery. 2011 Academic Article GET IT
Times cited: 102
Phase 1 study of epigenetic priming with decitabine prior to standard induction chemotherapy for patients with AML. Blood. 2011 Academic Article GET IT
Times cited: 116
DNA methylation of the first exon is tightly linked to transcriptional silencing. PloS one. 2011 Academic Article GET IT
Times cited: 431
Epigenomic reorganization of the clustered Hox genes in embryonic stem cells induced by retinoic acid. The Journal of biological chemistry. 2010 Academic Article GET IT
Times cited: 79
Tumor promoting properties of the ETS protein MEF in ovarian cancer. Oncogene. 2007 Academic Article GET IT
Times cited: 30
Advances in the molecular genetics of acute leukemia. Current oncology reports. 2005 Review GET IT
Times cited: 3
Structural integrity and expression of the L3MBTL gene in normal and malignant hematopoietic cells. Genes, chromosomes & cancer. 2004 Academic Article GET IT
Times cited: 35
Transforming growth factor beta-induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulation. Proceedings of the National Academy of Sciences of the United States of America. 2004 Academic Article GET IT
Times cited: 199
The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6). The Journal of biological chemistry. 2003 Academic Article GET IT
Times cited: 89
Transcription factor fusions in acute leukemia: variations on a theme. Oncogene. 2002 Review GET IT
Times cited: 89
Structural and functional characterization of platelet receptor-mediated factor VIII binding. The Journal of biological chemistry. 2000 Academic Article GET IT
Times cited: 53
The mechanism by which heparin promotes the inhibition of coagulation factor XIa by protease nexin-2. The Journal of biological chemistry. 1997 Academic Article GET IT
Times cited: 20
Progress curve analysis of the kinetics with which blood coagulation factor XIa is inhibited by protease nexin-2. Biochemistry. 1997 Academic Article GET IT
Times cited: 40
A binding site expressed on the surface of activated human platelets is shared by factor X and prothrombin. Biochemistry. 1996 Academic Article GET IT
Times cited: 64
Factor X bound to the surface of activated human platelets is preferentially activated by platelet-bound factor IXa. Biochemistry. 1996 Academic Article GET IT
Times cited: 37

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Research

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Funding awarded

Tracking MPN Fitness to speed development of disease modifying agents for MPNs awarded by MPN Research Foundation Principal Investigator 2023 - 2024
Targeting MPN and Progenitor Cells awarded by AbbVie Inc. Principal Investigator 2022 - 2024
Early intervention for the prevention of blood cancer development. awarded by Starr Cancer Consortium Principal Investigator 2022 - 2023
Immunologic Eradication of Myeloproliferative Neoplasm Stem Cells awarded by Daedalus Fund for Innovation (Weill Cornell) Principal Investigator 2022 - 2023

Endothelial cell transplantation for multi-organ repair to counter radiation injury awarded by National Institute of Allergy & Infectious Diseases Co-Investigator 2018 - 2024
Weill Cornell Training Program in Stem Cell Biology and Regenerative Medicine awarded by New York State Stem Cell Science (NYSTEM) Co-Investigator 2018 - 2023

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Background

education and training

M.D., Ph.D., Temple University School of Medicine 1997
M.S., University of Pennsylvania 1992
B.S., Cornell University 1987

Contact

full name

Joseph M Scandura

primary email

jms2003@med.cornell.edu

webpage

Clinical Profile

VIVO Weill Cornell Medical College

Joseph M Scandura Associate Professor of Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage