selected publications
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Comparison of Outcome Adjudication by Investigators and by a Central End Point Committee in Heart Failure Trials: Experience of the SHIFT Heart Failure Study.
Circulation. Heart failure.
2020
Academic Article
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Times cited: 20 -
Survival after Aortic Valve Replacement for Aortic Regurgitation: Prediction from Preoperative Contractility Measurement.
Cardiology.
2018
Academic Article
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Times cited: 6 -
Impact of Beta-Blockade on Cardiac Events in Patients with Chronic Severe Nonischemic Mitral Regurgitation.
Cardiology.
2017
Academic Article
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Times cited: 2 -
Relation of indirect vasodilator use to prognosis in patients with chronic severe mitral regurgitation.
Cardiology.
2014
Academic Article
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Times cited: 5 -
Resting heart rate: risk indicator and emerging risk factor in cardiovascular disease.
The American journal of medicine.
2014
Review
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Times cited: 128 -
Usefulness of preoperative exercise tolerance to predict late survival and symptom persistence after surgery for chronic nonischemic mitral regurgitation.
The American journal of cardiology.
2013
Academic Article
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Times cited: 1 -
Nonischemic mitral regurgitation: prognostic value of nonsustained ventricular tachycardia after mitral valve surgery.
Cardiology.
2013
Academic Article
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Times cited: 11 -
Surrogate endpoints in randomized cardiovascular clinical trials.
Fundamental & clinical pharmacology.
2010
Review
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Times cited: 13 -
Low-dose spironolactone: effects on artery-to-artery vein grafts and percutaneous coronary intervention sites.
American journal of therapeutics.
2009
Academic Article
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Times cited: 5 -
Unconventional end points in cardiovascular clinical trials: should we be moving away from morbidity and mortality?.
Journal of cardiac failure.
2008
Academic Article
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Times cited: 26 -
Acceptability and psychometric properties of the Minnesota Living With Heart Failure Questionnaire among patients undergoing heart valve surgery: validation and comparison with SF-36.
Journal of cardiac failure.
2008
Academic Article
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Times cited: 55 - Nitric oxide synthase inhibitor (MTR-105) during open-heart surgery. A pilot double-blind placebo-controlled study of hemodynamic effects and safety. Cardiology. 2008 Academic Article GET IT
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When should data and safety monitoring committees share interim results in cardiovascular trials?.
JAMA.
2008
Academic Article
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Times cited: 12 -
Characterization of the heart rate-lowering action of ivabradine, a selective I(f) current inhibitor.
American journal of therapeutics.
2008
Review
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Times cited: 48 -
Similarities and differences in design considerations for cell therapy and pharmacologic cardiovascular clinical trials.
Cardiology.
2007
Review
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Times cited: 3 -
Resting heart rate in cardiovascular disease.
Journal of the American College of Cardiology.
2007
Review
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Times cited: 830 -
Prognostic value of exercise tolerance testing in asymptomatic chronic nonischemic mitral regurgitation.
The American journal of cardiology.
2007
Academic Article
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Times cited: 33 -
Cardiovascular safety of drugs not intended for cardiovascular use: need for a new conceptual basis for assessment and approval.
European heart journal.
2007
Review
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Times cited: 20 - Valves in the heart of the Big Apple V. Expert review of cardiovascular therapy. 2007 Conference Paper GET IT
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Teaching clinical research methodology to the academic medical community: a fifteen-year retrospective of a comprehensive curriculum.
Medical teacher.
2007
Academic Article
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Times cited: 6 -
The Editor's Roundtable: cardiac valve surgery.
The American journal of cardiology.
2007
Academic Article
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Times cited: 22 -
Risk of cardiovascular events in patients receiving celecoxib: a meta-analysis of randomized clinical trials.
The American journal of cardiology.
2006
Review
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Times cited: 172 -
Equilibrium radionuclide angiocardiography.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology.
2006
Editorial Article
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Times cited: 74 -
Cellular and molecular basis of remodeling in valvular heart diseases.
Heart failure clinics.
2006
Review
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Times cited: 11 -
The epidemiology of valvular heart disease: a growing public health problem.
Heart failure clinics.
2006
Review
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Times cited: 126 -
Should angiotensin-converting enzyme-inhibitors be used to improve outcome in patients with coronary artery disease and 'preserved' left ventricular function?.
European heart journal.
2006
Academic Article
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Times cited: 13 -
Therapeutic effects of I(f) blockade: evidence and perspective.
Pharmacological research.
2006
Review
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Times cited: 21 -
Clinical effect of 'pure' heart rate slowing with a prototype If current inhibitor: placebo-controlled experience with ivabradine.
Advances in cardiology.
2006
Review
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Times cited: 2 -
Cyclooxygenase inhibition: what should we do to resolve the confusion? An American perspective.
Journal of cardiovascular pharmacology.
2006
Academic Article
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Times cited: 2 -
Prognostic impact of systolic hypertension on asymptomatic patients with chronic severe aortic regurgitation and initially normal left ventricular performance at rest.
The American journal of cardiology.
2005
Academic Article
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Times cited: 15 -
Cardiovascular and gastrointestinal effects of COX-2 inhibitors and NSAIDs: achieving a balance.
Arthritis research & therapy.
2005
Review
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Times cited: 69 -
Aortic stenosis and statins: more evidence of "pleotropy"?.
Arteriosclerosis, thrombosis, and vascular biology.
2005
Editorial Article
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Times cited: 8 -
Development of cardiovascular drugs: the U.S. regulatory milieu from the perspective of a participating nonregulator.
Journal of the American College of Cardiology.
2004
Academic Article
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Times cited: 15 -
Drug insight: If inhibitors as specific heart-rate-reducing agents.
Nature clinical practice. Cardiovascular medicine.
2004
Review
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Times cited: 52 -
Mitral Regurgitation: Current Treatment Options and Their Selection.
Current treatment options in cardiovascular medicine.
2004
Academic Article
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Times cited: 3 -
Left ventricular hypertrophy in hypertrophic cardiomyopathy: what's in a phenotype?.
Journal of the American College of Cardiology.
2004
Editorial Article
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Times cited: 1 -
Targeted anticytokine therapy in patients with chronic heart failure: results of the Randomized Etanercept Worldwide Evaluation (RENEWAL).
Circulation.
2004
Academic Article
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Times cited: 985 -
Heart failure in aortic regurgitation: the role of primary fibrosis and its cellular and molecular pathophysiology.
Advances in cardiology.
2004
Review
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Times cited: 8 -
Left ventricular ejection fraction change with exercise versus ejection fraction at rest in coronary artery disease: implications for using ejection fraction variations in making therapeutic decisions.
American journal of therapeutics.
2004
Academic Article
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Times cited: 1 -
The epidemiology of valvular heart diseases: the problem is growing.
Advances in cardiology.
2004
Academic Article
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Times cited: 29 -
Valve surgery in the asymptomatic patient with aortic regurgitation: current indications and the effect of change rates in objective measures.
Advances in cardiology.
2004
Review
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Times cited: 1 -
Ventricular arrhythmias in mitral regurgitation: frequency, clinical and prognostic importance, management before and after mitral valve surgery.
Advances in cardiology.
2004
Review
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Times cited: 4 -
Vesnarinone-mediated alterations of gene expression in cardiac fibroblasts from aortic regurgitant hearts.
American journal of therapeutics.
2004
Academic Article
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Times cited: 3 -
Myocardial fibrosis in chronic aortic regurgitation: molecular and cellular responses to volume overload.
Circulation.
2002
Academic Article
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Times cited: 122 -
Aortic regurgitation: selection of asymptomatic patients for valve surgery.
Advances in cardiology.
2002
Review
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Times cited: 6 -
Importance of right ventricular performance measurement in selecting asymptomatic patients with mitral regurgitation for valve surgery.
Advances in cardiology.
2002
Review
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Times cited: 21 -
Mitral regurgitation: natural history in operated and unoperated patients.
Advances in cardiology.
2002
Review
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Times cited: 3 -
Severe mitral regurgitation due to mitral valve prolapse: risk factors for development, progression, and need for mitral valve surgery.
The American journal of cardiology.
2000
Academic Article
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Times cited: 41 -
Preoperative predictors of late postoperative outcome among patients with nonischemic mitral regurgitation with 'high risk' descriptors and comparison with unoperated patients.
Cardiology.
2000
Academic Article
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Times cited: 41 -
Intracardiac Doppler hemodynamics and flow: new vector, phased-array ultrasound-tipped catheter.
The American journal of cardiology.
1999
Academic Article
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Times cited: 56 -
American Society of Nuclear Cardiology position statement on electrocardiographic gating of myocardial perfusion SPECT scintigrams.
1999
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Times cited: 55 -
Time-voltage QRS area of the 12-lead electrocardiogram: detection of left ventricular hypertrophy.
Hypertension (Dallas, Tex. : 1979).
1998
Academic Article
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Times cited: 71 -
Prediction of indications for valve replacement among asymptomatic or minimally symptomatic patients with chronic aortic regurgitation and normal left ventricular performance.
Circulation.
1998
Academic Article
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Times cited: 213 -
Relation of ultra-low frequency heart rate variability to the clinical course of chronic aortic regurgitation.
The American journal of cardiology.
1997
Academic Article
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Times cited: 10 -
Usefulness of subnormal midwall fractional shortening in predicting left ventricular exercise dysfunction in asymptomatic patients with systemic hypertension.
The American journal of cardiology.
1997
Academic Article
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Times cited: 43 -
Rhythm annotation and interobserver reproducibility of measures of heart rate variability.
The American journal of cardiology.
1996
Academic Article
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Times cited: 6 -
Combined rest and exercise electrocardiographic repolarization findings in relation to structural and functional abnormalities in asymptomatic aortic regurgitation.
American heart journal.
1996
Academic Article
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Times cited: 5 -
Transient loss of complete bundle branch block patterns during exercise.
The American journal of cardiology.
1995
Academic Article
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Times cited: 3 -
Variability of the ventricular response in atrial fibrillation and prognosis in chronic nonischemic mitral regurgitation.
The American journal of cardiology.
1994
Academic Article
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Times cited: 61 -
Natural history of the asymptomatic/minimally symptomatic patient with severe mitral regurgitation secondary to mitral valve prolapse and normal right and left ventricular performance.
The American journal of cardiology.
1994
Academic Article
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Times cited: 140 -
Electrocardiographic diagnosis of left ventricular hypertrophy by the time-voltage integral of the QRS complex.
Journal of the American College of Cardiology.
1994
Academic Article
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Times cited: 40 -
Position statement: clinical use of cardiac positron emission tomography. Position paper of the Cardiovascular Council of the Society of Nuclear Medicine.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
1993
Academic Article
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Times cited: 14 -
Prognostic value and physiological correlates of heart rate variability in chronic severe mitral regurgitation.
Circulation.
1993
Academic Article
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Times cited: 100 -
Prevalence of anticardiolipin antibody in isolated mitral or aortic regurgitation, or both, and possible relation to cerebral ischemic events.
The American journal of cardiology.
1992
Academic Article
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Times cited: 36 -
Left ventricular diastolic and systolic performance during chronic experimental aortic regurgitation.
The American journal of physiology.
1992
Academic Article
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Times cited: 28 -
Fractal clustering of ventricular ectopy and sudden death in mitral regurgitation.
Journal of electrocardiology.
1992
Academic Article
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Times cited: 8 -
Prognostic value of heart rate variability measures in patients with chronic, nonischemic mitral regurgitation.
Journal of electrocardiology.
1992
Academic Article
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Times cited: 2 -
Natural history of left ventricular performance at rest and during exercise after aortic valve replacement for aortic regurgitation.
Circulation.
1991
Academic Article
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Times cited: 37 -
Anticardiolipin antibody and stroke: possible relation of valvular heart disease and embolic events.
Cardiology.
1991
Academic Article
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Times cited: 52 -
Preoperative left and right ventricular performance in combined aortic and mitral regurgitation and comparison with isolated aortic or mitral regurgitation.
The American journal of cardiology.
1990
Academic Article
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Times cited: 33 -
Relation of obesity, high sodium intake, and eccentric left ventricular hypertrophy to left ventricular exercise dysfunction in essential hypertension.
The American journal of medicine.
1990
Academic Article
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Times cited: 65 -
Relationship of atrial natriuretic factor to left ventricular volume and mass.
American heart journal.
1989
Academic Article
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Times cited: 14 -
Reversal of left ventricular dilatation, hypertrophy, and dysfunction by valve replacement in aortic regurgitation.
American heart journal.
1989
Academic Article
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Times cited: 41 -
Comparison of mitral valve dimensions and motion in mitral valve prolapse with severe mitral regurgitation to uncomplicated mitral valve prolapse and to mitral regurgitation without mitral valve prolapse.
The American journal of cardiology.
1988
Academic Article
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Times cited: 32 -
Relation of concentric left ventricular hypertrophy and extracardiac target organ damage to supranormal left ventricular performance in established essential hypertension.
The American journal of cardiology.
1988
Academic Article
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Times cited: 66 -
Identification of anatomically extensive coronary artery disease by the exercise ECG ST segment/heart rate slope.
American heart journal.
1988
Academic Article
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Times cited: 42 -
Hypertrophic and functional response to experimental chronic aortic regurgitation.
Journal of molecular and cellular cardiology.
1988
Academic Article
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Times cited: 24 -
Relation of sudden death in pure mitral regurgitation, with and without mitral valve prolapse, to repetitive ventricular arrhythmias and right and left ventricular ejection fractions.
The American journal of cardiology.
1987
Academic Article
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Times cited: 54 -
Aortic root dilatation as a cause of isolated, severe aortic regurgitation. Prevalence, clinical and echocardiographic patterns, and relation to left ventricular hypertrophy and function.
Annals of internal medicine.
1987
Academic Article
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Times cited: 144 -
Evaluation of the exercise electrocardiogram by the ST segment/heart rate slope.
Bulletin of the New York Academy of Medicine.
1987
Academic Article
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Times cited: 1 -
Relationship of the electrocardiographic response to exercise to geometric and functional findings in aortic regurgitation.
American heart journal.
1987
Academic Article
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Times cited: 6 -
Radionuclide cineangiography in acute myocardial infarction: role in prognostication.
Seminars in nuclear medicine.
1987
Review
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Times cited: 11 -
Geometric and functional correlates of electrocardiographic repolarization and voltage abnormalities in aortic regurgitation.
Journal of the American College of Cardiology.
1987
Academic Article
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Times cited: 47 -
Left ventricular hypertrophy in hypertension. Prevalence and relationship to pathophysiologic variables.
Hypertension (Dallas, Tex. : 1979).
1987
Review
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Times cited: 150 -
Relationship of prior myocardial infarction to false-positive electrocardiographic diagnosis of acute injury in patients with chest pain.
Archives of internal medicine.
1987
Academic Article
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Times cited: 36 -
Cardiac structure and function in renovascular hypertension produced by unilateral and bilateral renal artery stenosis.
The American journal of cardiology.
1986
Academic Article
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Times cited: 72 -
Evaluation of coronary artery disease by an improved method of exercise electrocardiography: the ST segment/heart rate slope.
American heart journal.
1986
Academic Article
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Times cited: 51 -
Effects of recent and remote infarction on the predictive accuracy of the ST segment/heart rate slope.
Journal of the American College of Cardiology.
1986
Academic Article
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Times cited: 16 -
Randomized double-blind trial of intravenous streptokinase for acute myocardial infarction.
The American journal of cardiology.
1986
Academic Article
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Times cited: 36 -
Lead specificity of the maximum ST/heart rate slope response.
British heart journal.
1986
Letter
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Times cited: 2 -
Mitral regurgitation: relationship of noninvasive descriptors of right and left ventricular performance to clinical and hemodynamic findings and to prognosis in medically and surgically treated patients.
Circulation.
1986
Academic Article
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Times cited: 128 -
Long-term follow-up of patients with mitral-valve prolapse.
The New England journal of medicine.
1986
Letter
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Times cited: 5 -
Relation of hemoglobin A1 and blood glucose to cardiac function in diabetes mellitus.
The American journal of cardiology.
1985
Academic Article
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Times cited: 25 -
Correlation of the exercise ST/HR slope with anatomic and radionuclide cineangiographic findings in stable angina pectoris.
The American journal of cardiology.
1985
Academic Article
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Times cited: 28 -
Complex arrhythmias in mitral regurgitation with and without mitral valve prolapse: contrast to arrhythmias in mitral valve prolapse without mitral regurgitation.
The American journal of cardiology.
1985
Academic Article
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Times cited: 81 -
Predictive value and limitations of the ST/HR slope.
British heart journal.
1985
Academic Article
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Times cited: 21 -
Improved accuracy of the exercise electrocardiogram: identification of three-vessel coronary disease in stable angina pectoris by analysis of peak rate-related changes in ST segments.
The American journal of cardiology.
1985
Academic Article
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Times cited: 42 -
Increased cardiac performance in mild essential hypertension. Left ventricular mechanics.
Hypertension (Dallas, Tex. : 1979).
1985
Academic Article
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Times cited: 137 -
Hemodynamic effects of nifedipine versus hydralazine in primary pulmonary hypertension.
The American journal of cardiology.
1984
Academic Article
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Times cited: 23 -
Duration of ejection in aortic stenosis: effect of stroke volume and pressure gradient.
Journal of the American College of Cardiology.
1984
Academic Article
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Times cited: 10 -
The cardiomyopathies. A pathophysiologic approach to therapeutic management.
Archives of internal medicine.
1983
Academic Article
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Times cited: 8 -
Function of the hypertrophied left ventricle at rest and during exercise. Hypertension and aortic stenosis.
The American journal of medicine.
1983
Academic Article
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Times cited: 41 -
Left ventricular hypertrophy in patients with hypertension: importance of blood pressure response to regularly recurring stress.
Circulation.
1983
Academic Article
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Times cited: 701 -
Left ventricular performance in the hypertensive patient. Exercise-mediated noninvasive separation of loading influences from intrinsic muscle dysfunction.
Chest.
1983
Academic Article
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Times cited: 18 -
Myocardial free-wall rupture after acute infarction: survival aided by percutaneous intraaortic balloon counterpulsation.
1982
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Times cited: 31 -
Exercise testing early after myocardial infarction. Risks and benefits.
The American journal of medicine.
1982
Review
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Times cited: 19 -
Libman-Sacks endocardoma: diagnosis during life with radiographic, fluoroscopic, and angiocardiographic findings.
Radiology.
1974
Academic Article
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Times cited: 5