Brown, Kristy A.

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Update on Adipose Tissue and Cancer. Endocrine reviews. 2023 Academic Article GET IT
Linking Physical Activity to Breast Cancer Risk via Inflammation, Part 1: The Effect of Physical Activity on Inflammation. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2023 Academic Article GET IT
Times cited: 1
Linking Physical Activity to Breast Cancer via Inflammation, Part 2: The Effect of Inflammation on Breast Cancer Risk. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2023 Editorial Article GET IT
Times cited: 2
Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2. Science translational medicine. 2023 Academic Article GET IT
Times cited: 2
Breast adipose tissue-derived extracellular vesicles from women with obesity stimulate mitochondrial-induced dysregulated tumor cell metabolism. bioRxiv : the preprint server for biology. 2023 Article GET IT
Facts and Perspectives: Implications of tumor glycolysis on immunotherapy response in triple negative breast cancer. Frontiers in oncology. 2023 Review GET IT
Times cited: 12
Adrenal Steroids and Resistance to Hormonal Blockade of Prostate and Breast Cancer. Endocrinology. 2023 Review GET IT
Times cited: 1
Linking Physical Activity to Breast Cancer Risk via Insulin/Insulin-Like Growth Factor Signaling System, Part 1: The Effect of Physical Activity on the Insulin/Insulin-Like Growth Factor Signaling System. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2022 Academic Article GET IT
Times cited: 2
Linking Physical Activity to Breast Cancer Risk via the Insulin/Insulin-like Growth Factor Signaling System, Part 2: The Effect of Insulin/Insulin-like Growth Factor Signaling on Breast Cancer Risk. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2022 Review GET IT
Times cited: 2
Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2. Cell metabolism. 2021 Article GET IT
Times cited: 11
Linking Physical Activity to Breast Cancer via Sex Hormones, Part 1: The Effect of Physical Activity on Sex Steroid Hormones. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2021 Review GET IT
Times cited: 3
Linking Physical Activity to Breast Cancer via Sex Steroid Hormones, Part 2: The Effect of Sex Steroid Hormones on Breast Cancer Risk. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2021 Comment GET IT
Times cited: 4
Linking Physical Activity to Breast Cancer: Text Mining Results and a Protocol for Systematically Reviewing Three Potential Mechanistic Pathways. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2021 Review GET IT
Times cited: 4
Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2. Cell metabolism. 2021 Academic Article GET IT
Times cited: 86
Metabolic pathways in obesity-related breast cancer. Nature reviews. Endocrinology. 2021 Review GET IT
Times cited: 51
Targeting obesity-related dysfunction in hormonally driven cancers. British journal of cancer. 2021 Review GET IT
Times cited: 21
Obese Adipose Tissue as a Driver of Breast Cancer Growth and Development: Update and Emerging Evidence. Frontiers in oncology. 2021 Review GET IT
Times cited: 32
Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. Cell. 2020 Academic Article GET IT
Times cited: 477
Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531. eLife. 2020 Academic Article GET IT
Times cited: 5
Tissue Engineering Models for the Study of Breast Neoplastic Disease and the Tumor Microenvironment. Tissue engineering. Part B, Reviews. 2020 Review GET IT
Times cited: 1
Endocrine Therapy-related Endocrinopathies-Biology, Prevalence and Implications for the Management of Breast Cancer. Oncology & hematology review. 2020 Academic Article GET IT
Inhibition of EZH2 Catalytic Activity Selectively Targets a Metastatic Subpopulation in Triple-Negative Breast Cancer. Cell reports. 2020 Academic Article GET IT
Times cited: 51
Withdrawal: Hsp90 and PKM2 drive the expression of aromatase in Li-Fraumeni syndrome breast adipose stromal cells. The Journal of biological chemistry. 2020 Academic Article GET IT
Times cited: 1
Estrogens and breast cancer: Mechanisms involved in obesity-related development, growth and progression. The Journal of steroid biochemistry and molecular biology. 2019 Review GET IT
Times cited: 71
No effect of unacylated ghrelin administration on subcutaneous PC3 xenograft growth or metabolic parameters in a Rag1-/- mouse model of metabolic dysfunction. PloS one. 2018 Academic Article GET IT
Times cited: 3
The benefits of adding metformin to tamoxifen to protect the endometrium-A randomized placebo-controlled trial. Clinical endocrinology. 2018 Academic Article GET IT
Times cited: 19
A 3-Dimensional Biomimetic Platform to Interrogate the Safety of Autologous Fat Transfer in the Setting of Breast Cancer. Annals of plastic surgery. 2018 Academic Article GET IT
Times cited: 4
IL-10 suppresses TNF-α-induced expression of human aromatase gene in mammary adipose tissue. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2018 Academic Article GET IT
Times cited: 20
Leptin regulation of the p53-HIF1α/PKM2-aromatase axis in breast adipose stromal cells: a novel mechanism for the obesity-breast cancer link. International journal of obesity (2005). 2017 Academic Article GET IT
Times cited: 45
Obesity and breast cancer - Role of estrogens and the molecular underpinnings of aromatase regulation in breast adipose tissue. Molecular and cellular endocrinology. 2017 Review GET IT
Times cited: 82
Editorial. The Journal of steroid biochemistry and molecular biology. 2017 Editorial Article GET IT
Menopause Is a Determinant of Breast Aromatase Expression and Its Associations With BMI, Inflammation, and Systemic Markers. The Journal of clinical endocrinology and metabolism. 2017 Academic Article GET IT
Times cited: 65
Metabolic Obesity, Adipose Inflammation and Elevated Breast Aromatase in Women with Normal Body Mass Index. Cancer prevention research (Philadelphia, Pa.). 2017 Academic Article GET IT
Times cited: 108
Ghrelin and Breast Cancer: Emerging Roles in Obesity, Estrogen Regulation, and Cancer. Frontiers in oncology. 2017 Review GET IT
Times cited: 14
Inflammation, dysregulated metabolism and aromatase in obesity and breast cancer. Current opinion in pharmacology. 2016 Review GET IT
Times cited: 57
The presence and impact of estrogen metabolism on the biology of triple-negative breast cancer. Breast cancer research and treatment. 2016 Academic Article GET IT
Times cited: 17
Des-acyl ghrelin inhibits the capacity of macrophages to stimulate the expression of aromatase in breast adipose stromal cells. The Journal of steroid biochemistry and molecular biology. 2016 Academic Article GET IT
Times cited: 18
Hsp90 and PKM2 Drive the Expression of Aromatase in Li-Fraumeni Syndrome Breast Adipose Stromal Cells. The Journal of biological chemistry. 2016 Academic Article GET IT
Times cited: 5
Correction: p53: Protection against Tumor Growth beyond Effects on Cell Cycle and Apoptosis. Cancer research. 2016 Academic Article GET IT
Immunolocalisation of aromatase regulators liver kinase B1, phosphorylated AMP-activated protein kinase and cAMP response element-binding protein-regulated transcription co-activators in the human testis. Reproduction, fertility, and development. 2016 Academic Article GET IT
Times cited: 3
p53: Protection against Tumor Growth beyond Effects on Cell Cycle and Apoptosis. Cancer research. 2015 Review GET IT
Times cited: 203
Aromatase overexpression in dysfunctional adipose tissue links obesity to postmenopausal breast cancer. The Journal of steroid biochemistry and molecular biology. 2015 Review GET IT
Times cited: 83
High mammographic density is associated with an increase in stromal collagen and immune cells within the mammary epithelium. Breast cancer research : BCR. 2015 Academic Article GET IT
Times cited: 111
Estrogens, obesity, inflammation, and breast cancer-what is the link?. Seminars in reproductive medicine. 2015 Review GET IT
Times cited: 6
Obesity-Associated Inflammatory Cytokines and Prostaglandin E2 Stimulate Glucose Transporter mRNA Expression and Glucose Uptake in Primary Human Adipose Stromal Cells. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 2015 Academic Article GET IT
Times cited: 13
Prostaglandin E2 inhibits p53 in human breast adipose stromal cells: a novel mechanism for the regulation of aromatase in obesity and breast cancer. Cancer research. 2015 Academic Article GET IT
Times cited: 42
Ghrelin and des-acyl ghrelin inhibit aromatase expression and activity in human adipose stromal cells: suppression of cAMP as a possible mechanism. Breast cancer research and treatment. 2014 Academic Article GET IT
Times cited: 27
Impact of obesity on mammary gland inflammation and local estrogen production. Journal of mammary gland biology and neoplasia. 2014 Review GET IT
Times cited: 30
Androgenic pathways in the progression of triple-negative breast carcinoma: a comparison between aggressive and non-aggressive subtypes. Breast cancer research and treatment. 2014 Academic Article GET IT
Times cited: 31
Conditional overexpression of liver receptor homolog-1 in female mouse mammary epithelium results in altered mammary morphogenesis via the induction of TGF-β. Endocrinology. 2014 Academic Article GET IT
Times cited: 8
Obesity and breast cancer: role of inflammation and aromatase. Journal of molecular endocrinology. 2013 Review GET IT
Times cited: 71
Genomic basis of aromatase excess syndrome: recombination- and replication-mediated rearrangements leading to CYP19A1 overexpression. 2013 GET IT
Times cited: 18
Overexpression of aromatase associated with loss of heterozygosity of the STK11 gene accounts for prepubertal gynecomastia in boys with Peutz-Jeghers syndrome. 2013 GET IT
Times cited: 24
CREB-regulated transcription co-activator family stimulates promoter II-driven aromatase expression in preadipocytes. Hormones & cancer. 2013 Academic Article GET IT
Times cited: 30
HIF-1α stimulates aromatase expression driven by prostaglandin E2 in breast adipose stroma. Breast cancer research : BCR. 2013 Academic Article GET IT
Times cited: 47
Minireview: Obesity and breast cancer: a tale of inflammation and dysregulated metabolism. Molecular endocrinology (Baltimore, Md.). 2013 Review GET IT
Times cited: 63
Endocrine-related cancers and the role of AMPK. Molecular and cellular endocrinology. 2012 Review GET IT
Times cited: 52
Obesity and breast cancer: mechanisms and therapeutic implications. Frontiers in bioscience (Elite edition). 2012 Review GET IT
Times cited: 34
Anti-Müllerian hormone reduces follicle sensitivity to follicle-stimulating hormone in human granulosa cells. Fertility and sterility. 2011 Academic Article GET IT
Times cited: 186
Regulation of LKB1 expression by sex hormones in adipocytes. International journal of obesity (2005). 2011 Academic Article GET IT
Times cited: 42
Teasing out the role of aromatase in the healthy and diseased testis. Spermatogenesis. 2011 Academic Article GET IT
Times cited: 188
LKB1 expression is inhibited by estradiol-17β in MCF-7 cells. The Journal of steroid biochemistry and molecular biology. 2011 Academic Article GET IT
Times cited: 24
Obesity, aromatase and breast cancer. Expert review of endocrinology & metabolism. 2011 Academic Article GET IT
Times cited: 14
Promoter-specific effects of metformin on aromatase transcript expression. Steroids. 2011 Academic Article GET IT
Times cited: 31
Metformin inhibits aromatase expression in human breast adipose stromal cells via stimulation of AMP-activated protein kinase. Breast cancer research and treatment. 2010 Academic Article GET IT
Times cited: 111
Obesity and breast cancer: progress to understanding the relationship. Cancer research. 2009 Review GET IT
Times cited: 104
Progress in aromatase research and identification of key future directions. The Journal of steroid biochemistry and molecular biology. 2009 Academic Article GET IT
Times cited: 4
Subcellular localization of cyclic AMP-responsive element binding protein-regulated transcription coactivator 2 provides a link between obesity and breast cancer in postmenopausal women. Cancer research. 2009 Academic Article GET IT
Times cited: 91
Characterisation of aromatase expression in the human adipocyte cell line SGBS. Breast cancer research and treatment. 2008 Academic Article GET IT
Times cited: 24
Gonadotropin-dependent regulation of bovine pituitary adenylate cyclase-activating polypeptide in ovarian follicles prior to ovulation. Reproduction (Cambridge, England). 2007 Academic Article GET IT
Times cited: 16
Molecular cloning of equine 17beta-hydroxysteroid dehydrogenase type 1 and its downregulation during follicular luteinization in vivo. Journal of molecular endocrinology. 2007 Academic Article GET IT
Times cited: 8
Down-regulation of messenger ribonucleic acid encoding an importer of sulfoconjugated steroids during human chorionic gonadotropin-induced follicular luteinization in vivo. The Journal of steroid biochemistry and molecular biology. 2006 Academic Article GET IT
Times cited: 11
Characterization of bovine early growth response factor-1 and its gonadotropin-dependent regulation in ovarian follicles prior to ovulation. Journal of molecular endocrinology. 2006 Academic Article GET IT
Times cited: 34
Human chorionic gonadotropin-dependent up-regulation of genes responsible for estrogen sulfoconjugation and export in granulosa cells of luteinizing preovulatory follicles. Endocrinology. 2006 Academic Article GET IT
Times cited: 12
Human chorionic gonadotropin-dependent induction of an equine aldo-keto reductase (AKR1C23) with 20alpha-hydroxysteroid dehydrogenase activity during follicular luteinization in vivo. Journal of molecular endocrinology. 2006 Academic Article GET IT
Times cited: 14
Molecular characterization of equine P-selectin (CD62P) and its regulation in ovarian follicles during the ovulatory process. Biology of reproduction. 2004 Academic Article GET IT
Times cited: 8
Cyclooxygenase-2 and its role in ovulation: a 2004 account. Human reproduction update. 2004 Review GET IT
Times cited: 169
Human chorionic gonadotropin-dependent regulation of 17beta-hydroxysteroid dehydrogenase type 4 in preovulatory follicles and its potential role in follicular luteinization. Endocrinology. 2004 Academic Article GET IT
Times cited: 21
Expression of key prostaglandin synthases in equine endometrium during late diestrus and early pregnancy. Biology of reproduction. 2003 Academic Article GET IT
Times cited: 95
Induction of hyaluronan synthase 2 by human chorionic gonadotropin in mural granulosa cells of equine preovulatory follicles. Endocrinology. 2002 Academic Article GET IT
Times cited: 24

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Background

education and training

Ph.D., University of Montreal (Canada) 2006
B.Sc., McGill University (Canada) 2000

Contact

full name

Kristy A. Brown

primary email

kab2060@med.cornell.edu

VIVO Weill Cornell Medical College

Kristy A. Brown Associate Professor of Biochemistry in Medicine

Publications

selected publications

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Background

education and training

Contact

full name

primary email