Alonso, Laura

Publications

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selected publications

Serological screening of SARS-CoV-2 infection in companion animals of Buenos Aires suburbs. Frontiers in veterinary science. 2023 Academic Article GET IT
Times cited: 10
High-throughput analysis of ANRIL circRNA isoforms in human pancreatic islets. Scientific reports. 2022 Academic Article GET IT
Weight Loss Outcomes With Telemedicine During COVID-19. Frontiers in endocrinology. 2022 Academic Article GET IT
Times cited: 99
Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance. Nature communications. 2022 Academic Article GET IT
Times cited: 12
Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2. Cell metabolism. 2021 Article GET IT
Times cited: 11
Ergocalciferol in New-onset Type 1 Diabetes: A Randomized Controlled Trial. Journal of the Endocrine Society. 2021 Academic Article GET IT
Times cited: 5
Deciphering CHFR Role in Pancreatic Ductal Adenocarcinoma. Frontiers in medicine. 2021 Academic Article GET IT
Living Dangerously: Protective and Harmful ER Stress Responses in Pancreatic β-Cells. Diabetes. 2021 Review GET IT
Times cited: 16
Early Diagnosis and Treatment of Purine Nucleoside Phosphorylase (PNP) Deficiency through TREC-Based Newborn Screening. 2021 GET IT
Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2. Cell metabolism. 2021 Academic Article GET IT
Times cited: 86
Endoplasmic Reticulum Stress Induced Proliferation Remains Intact in Aging Mouse β-Cells. Frontiers in endocrinology. 2021 Academic Article GET IT
Times cited: 22
Career Advancement for Women in Diabetes-Related Research: Developing and Retaining Female Talent. Diabetes. 2021 Academic Article GET IT
Times cited: 3
Career Advancement for Women in Diabetes-Related Research: Developing and Retaining Female Talent. Diabetes care. 2021 Comment GET IT
Times cited: 3
Preadmission predictors of severe COVID-19 in patients with diabetes mellitus. Journal of diabetes and its complications. 2021 Academic Article GET IT
Times cited: 4
In vivo screen identifies a SIK inhibitor that induces β cell proliferation through a transient UPR. Nature metabolism. 2021 Academic Article GET IT
Times cited: 13
The Independent Risk of Obesity and Diabetes and Their Interaction in COVID-19: A Retrospective Cohort Study. Obesity (Silver Spring, Md.). 2021 Academic Article GET IT
Times cited: 11
Hyperglycemia in Acute COVID-19 is Characterized by Adipose Tissue Dysfunction and Insulin Resistance. medRxiv : the preprint server for health sciences. 2021 Article GET IT
Intersection of the ATF6 and XBP1 ER stress pathways in mouse islet cells. The Journal of biological chemistry. 2020 Academic Article GET IT
Times cited: 21
Continuous glucose monitoring reduces pubertal hyperglycemia of type 1 diabetes. Journal of pediatric endocrinology & metabolism : JPEM. 2020 Academic Article GET IT
Times cited: 3
Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis. Science signaling. 2019 Academic Article GET IT
Times cited: 26
Atf6α impacts cell number by influencing survival, death and proliferation. Molecular metabolism. 2019 Review GET IT
Times cited: 19
T2D Risk Genes: Exome Sequencing Goes Straight to the Source. Cell metabolism. 2019 Comment GET IT
Times cited: 3
DNA Damage Does Not Cause BrdU Labeling of Mouse or Human β-Cells. Diabetes. 2019 Academic Article GET IT
Times cited: 12
Adipose tissue-derived free fatty acids initiate myeloid cell accumulation in mouse liver in states of lipid oversupply. American journal of physiology. Endocrinology and metabolism. 2018 Academic Article GET IT
Times cited: 10
ANRIL: A lncRNA at the CDKN2A/B Locus With Roles in Cancer and Metabolic Disease. Frontiers in endocrinology. 2018 Review GET IT
Times cited: 95
Pancreatic Islet Embedding for Paraffin Sections. Journal of visualized experiments : JoVE. 2018 Academic Article GET IT
Times cited: 7
Children with type 1 diabetes who experienced a honeymoon phase had significantly lower LDL cholesterol 5 years after diagnosis. PloS one. 2018 Academic Article GET IT
Times cited: 15
CDKN2A/B T2D Genome-Wide Association Study Risk SNPs Impact Locus Gene Expression and Proliferation in Human Islets. Diabetes. 2018 Academic Article GET IT
Times cited: 37
Partial clinical remission in type 1 diabetes: a comparison of the accuracy of total daily dose of insulin of <0.3 units/kg/day to the gold standard insulin-dose adjusted hemoglobin A1c of ≤9 for the detection of partial clinical remission. Journal of pediatric endocrinology & metabolism : JPEM. 2017 Academic Article GET IT
Times cited: 22
A predictive model for lack of partial clinical remission in new-onset pediatric type 1 diabetes. PloS one. 2017 Academic Article GET IT
Times cited: 35
Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia. The Journal of biological chemistry. 2016 Academic Article GET IT
Times cited: 13
Islet biology, the CDKN2A/B locus and type 2 diabetes risk. Diabetologia. 2016 Review GET IT
Times cited: 55
In Vivo Selection Yields AAV-B1 Capsid for Central Nervous System and Muscle Gene Therapy. Molecular therapy : the journal of the American Society of Gene Therapy. 2016 Academic Article GET IT
Times cited: 86
PKCζ Is Essential for Pancreatic β-Cell Replication During Insulin Resistance by Regulating mTOR and Cyclin-D2. Diabetes. 2016 Academic Article GET IT
Times cited: 33
Glucose Induces Mouse β-Cell Proliferation via IRS2, MTOR, and Cyclin D2 but Not the Insulin Receptor. Diabetes. 2016 Academic Article GET IT
Times cited: 70
Insulin demand regulates β cell number via the unfolded protein response. The Journal of clinical investigation. 2015 Academic Article GET IT
Times cited: 136
Early initiation of low-level parenteral dextrose induces an accelerated diabetic phenotype in septic C57BL/6J mice. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. 2015 Academic Article GET IT
Times cited: 10
Evaluation, Medical Therapy, and Course of Adult Persistent Hyperinsulinemic Hypoglycemia After Roux-en-Y Gastric Bypass Surgery: A Case Series. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 2015 Academic Article GET IT
Times cited: 12
β-catenin links hepatic metabolic zonation with lipid metabolism and diet-induced obesity in mice. The American journal of pathology. 2014 Academic Article GET IT
Times cited: 46
Lipotoxicity in the pancreatic beta cell: not just survival and function, but proliferation as well?. Current diabetes reports. 2014 Review GET IT
Times cited: 91
Glucagon regulates hepatic kisspeptin to impair insulin secretion. Cell metabolism. 2014 Academic Article GET IT
Times cited: 160
Human β-cell regeneration: progress, hurdles, and controversy. Current opinion in endocrinology, diabetes, and obesity. 2014 Review GET IT
Times cited: 8
The islet estrogen receptor-α is induced by hyperglycemia and protects against oxidative stress-induced insulin-deficient diabetes. PloS one. 2014 Academic Article GET IT
Times cited: 35
Exogenous glucose administration impairs glucose tolerance and pancreatic insulin secretion during acute sepsis in non-diabetic mice. PloS one. 2013 Academic Article GET IT
Times cited: 14
Adaptive β-cell proliferation increases early in high-fat feeding in mice, concurrent with metabolic changes, with induction of islet cyclin D2 expression. American journal of physiology. Endocrinology and metabolism. 2013 Academic Article GET IT
Times cited: 96
Time-dependent changes in glucose and insulin regulation during intermittent hypoxia and continuous hypoxia. European journal of applied physiology. 2012 Academic Article GET IT
Times cited: 31
ChREBP mediates glucose-stimulated pancreatic β-cell proliferation. Diabetes. 2012 Academic Article GET IT
Times cited: 87
Loss of HGF/c-Met signaling in pancreatic β-cells leads to incomplete maternal β-cell adaptation and gestational diabetes mellitus. Diabetes. 2012 Academic Article GET IT
Times cited: 84
Free fatty acids block glucose-induced β-cell proliferation in mice by inducing cell cycle inhibitors p16 and p18. Diabetes. 2012 Academic Article GET IT
Times cited: 56
Simultaneous measurement of insulin sensitivity, insulin secretion, and the disposition index in conscious unhandled mice. Obesity (Silver Spring, Md.). 2012 Academic Article GET IT
Times cited: 38
Activation of protein kinase C-ζ in pancreatic β-cells in vivo improves glucose tolerance and induces β-cell expansion via mTOR activation. Diabetes. 2011 Academic Article GET IT
Times cited: 36
Disruption of hepatocyte growth factor/c-Met signaling enhances pancreatic beta-cell death and accelerates the onset of diabetes. Diabetes. 2010 Academic Article GET IT
Times cited: 88
Glucose stimulates human beta cell replication in vivo in islets transplanted into NOD-severe combined immunodeficiency (SCID) mice. Diabetologia. 2010 Academic Article GET IT
Times cited: 97
Hyperinsulinemia predicts survival in a hyperglycemic mouse model of critical illness. Critical care medicine. 2009 Academic Article GET IT
Times cited: 6
Intermittent hypoxia reverses the diurnal glucose rhythm and causes pancreatic beta-cell replication in mice. The Journal of physiology. 2007 Academic Article GET IT
Times cited: 102
Glucose infusion in mice: a new model to induce beta-cell replication. Diabetes. 2007 Academic Article GET IT
Times cited: 212
Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activity. American journal of respiratory and critical care medicine. 2007 Academic Article GET IT
Times cited: 286
The hair cycle. Journal of cell science. 2006 Review GET IT
Times cited: 384
Sgk3 links growth factor signaling to maintenance of progenitor cells in the hair follicle. The Journal of cell biology. 2005 Academic Article GET IT
Times cited: 46
Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA. The Journal of cell biology. 2003 Academic Article GET IT
Times cited: 210
Stem cells of the skin epithelium. Proceedings of the National Academy of Sciences of the United States of America. 2003 Review GET IT
Times cited: 398
Stem cells in the skin: waste not, Wnt not. Genes & development. 2003 Review GET IT
Times cited: 291
Molecular genetic and endocrine mechanisms of hair growth. Hormone research. 2003 Review GET IT
Times cited: 50
Oestrogens and puberty. Best practice & research. Clinical endocrinology & metabolism. 2002 Review GET IT
Times cited: 61
Functional characterization of soluble and membrane-bound forms of vaccinia virus complement control protein (VCP). Molecular immunology. 1999 Academic Article GET IT
Times cited: 36
Utility of adenoviral-mediated Fas ligand gene transfer to modulate islet allograft survival. Transplantation. 1998 Academic Article GET IT
Times cited: 37
Helium-ion-induced human cataractogenesis. Advances in space research : the official journal of the Committee on Space Research (COSPAR). 1994 Academic Article GET IT
Times cited: 6

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Research

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Co-investigator Network

Funding awarded

Research Training in Endocrinology and Metabolism awarded by National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator 2023 - 2028
Benefits and Harms of Activating ATF6 in Beta Cells awarded by National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator 2023 - 2026
CROSS-SPECIES STUDY TO IDENTIFY BARRIERS TO HUMAN PANCREATIC BETA CELL REGENERATION awarded by Tri-Institutional Stem Cell Initiative (Weill Cornell) Principal Investigator 2021 - 2023
Role of GRP78 in beta cell adaptation in obesity and diabetes awarded by National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator 2020 - 2023

Assessing the Impact of SARS-CoV-2 on Adipose Tissue Function and Glucose Homeostasis awarded by National Institute of Diabetes & Digestive & Kidney Diseases Co-Investigator 2023 - 2028

Role of Polyamines and Hypusine in Nutrient-Induced Beta-Cell Growth and Replication awarded by National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator Subaward 2020 - 2025
Regulation and Function of the Type 2 Diabetes-Associated C2CD4A/B Locus awarded by National Institute of Allergy & Infectious Diseases Principal Investigator Subaward 2019 - 2023

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Background

education and training

M.D., University of Pennsylvania School of Medicine 1998
B.A., Harvard College 1993

Contact

full name

Laura Alonso

primary email

lca4001@med.cornell.edu

webpage

Clinical Profile

VIVO Weill Cornell Medical College

Laura Alonso Professor of Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage