Kopelovich, Levy

Publications

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selected publications

Patched1 haploinsufficiency severely impacts intermediary metabolism in the skin of Ptch1^+/-/ODC transgenic mice. Scientific reports. 2019 Academic Article GET IT
Times cited: 1
ETHE1 overexpression promotes SIRT1 and PGC1α mediated aerobic glycolysis, oxidative phosphorylation, mitochondrial biogenesis and colorectal cancer. Oncotarget. 2019 Academic Article GET IT
Times cited: 11
Naproxen Inhibits UVB-induced Basal Cell and Squamous Cell Carcinoma Development in Ptch1^+/- /SKH-1 Hairless Mice. Photochemistry and photobiology. 2017 Academic Article GET IT
Times cited: 15
PPARs as determinants of the estrogen receptor lineage: use of synthetic lethality for the treatment of estrogen receptor-negative breast cancer. Oncotarget. 2017 Academic Article GET IT
Times cited: 1
Haploinsufficiency in tumor predisposition syndromes: altered genomic transcription in morphologically normal cells heterozygous for VHL or TSC mutation. Oncotarget. 2017 Academic Article GET IT
Times cited: 10
Targeting cancer stem cells with p53 modulators. Oncotarget. 2016 Academic Article GET IT
Times cited: 20
Shh and p50/Bcl3 signaling crosstalk drives pathogenesis of BCCs in Gorlin syndrome. Oncotarget. 2015 Academic Article GET IT
Times cited: 23
TP53 modulating agent, CP-31398 enhances antitumor effects of ODC inhibitor in mouse model of urinary bladder transitional cell carcinoma. American journal of cancer research. 2015 Academic Article GET IT
Sulindac reversal of 15-PGDH-mediated resistance to colon tumor chemoprevention with NSAIDs. Carcinogenesis. 2014 Academic Article GET IT
Times cited: 15
p53 modulates Hsp90 ATPase activity and regulates aryl hydrocarbon receptor signaling. Cancer prevention research (Philadelphia, Pa.). 2014 Academic Article GET IT
Times cited: 17
p53 protein regulates Hsp90 ATPase activity and thereby Wnt signaling by modulating Aha1 expression. The Journal of biological chemistry. 2014 Academic Article GET IT
Times cited: 29
Polymorphisms in alcohol metabolism genes ADH1B and ALDH2, alcohol consumption and colorectal cancer. PloS one. 2013 Academic Article GET IT
Times cited: 30
Heritable one-hit events defining cancer prevention?. Cell cycle (Georgetown, Tex.). 2013 Academic Article GET IT
Times cited: 10
Dietary polyphenols suppress elevated levels of proinflammatory mediators and aromatase in the mammary gland of obese mice. Cancer prevention research (Philadelphia, Pa.). 2013 Academic Article GET IT
Times cited: 34
Unbiased metabolite profiling indicates that a diminished thymidine pool is the underlying mechanism of colon cancer chemoprevention by alpha-difluoromethylornithine. Cancer discovery. 2013 Academic Article GET IT
Times cited: 39
Caloric restriction reverses obesity-induced mammary gland inflammation in mice. Cancer prevention research (Philadelphia, Pa.). 2013 Academic Article GET IT
Times cited: 47
Metabolic profiling, a noninvasive approach for the detection of experimental colorectal neoplasia. Cancer prevention research (Philadelphia, Pa.). 2012 Academic Article GET IT
Times cited: 40
Pioglitazone, a PPARγ agonist, suppresses CYP19 transcription: evidence for involvement of 15-hydroxyprostaglandin dehydrogenase and BRCA1. Cancer prevention research (Philadelphia, Pa.). 2012 Academic Article GET IT
Times cited: 23
Genetic polymorphisms in fatty acid metabolism genes and colorectal cancer. Mutagenesis. 2012 Academic Article GET IT
Times cited: 35
Increased levels of COX-2 and prostaglandin E2 contribute to elevated aromatase expression in inflamed breast tissue of obese women. Cancer discovery. 2012 Academic Article GET IT
Times cited: 214
Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways. Proceedings of the National Academy of Sciences of the United States of America. 2011 Academic Article GET IT
Times cited: 486
Inflammation and increased aromatase expression occur in the breast tissue of obese women with breast cancer. Cancer prevention research (Philadelphia, Pa.). 2011 Academic Article GET IT
Times cited: 371
Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland. Cancer prevention research (Philadelphia, Pa.). 2011 Academic Article GET IT
Times cited: 324
Altered folate availability modifies the molecular environment of the human colorectum: implications for colorectal carcinogenesis. Cancer prevention research (Philadelphia, Pa.). 2011 Academic Article GET IT
Times cited: 40
A molecular signature of normal breast epithelial and stromal cells from Li-Fraumeni syndrome mutation carriers. Oncotarget. 2010 Academic Article GET IT
Times cited: 30
Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer. Cancer prevention research (Philadelphia, Pa.). 2010 Academic Article GET IT
Times cited: 68
Sulindac effects on inflammation and tumorigenesis in the intestine of mice with Apc and Mlh1 mutations. Carcinogenesis. 2009 Academic Article GET IT
Times cited: 9
Dietary calcium and cholecalciferol modulate cyclin D1 expression, apoptosis, and tumorigenesis in intestine of adenomatous polyposis coli1638N/+ mice. The Journal of nutrition. 2008 Academic Article GET IT
Times cited: 48
The inhibitory effect of (-)-epigallocatechin gallate on activation of the epidermal growth factor receptor is associated with altered lipid order in HT29 colon cancer cells. Cancer research. 2007 Academic Article GET IT
Times cited: 183
Tobacco smoke stimulates the transcription of amphiregulin in human oral epithelial cells: evidence of a cyclic AMP-responsive element binding protein-dependent mechanism. Cancer research. 2005 Academic Article GET IT
Times cited: 48
Levels of cyclooxygenase-2 are increased in the oral mucosa of smokers: evidence for the role of epidermal growth factor receptor and its ligands. Cancer research. 2005 Academic Article GET IT
Times cited: 118
Tobacco smoke induces CYP1B1 in the aerodigestive tract. Carcinogenesis. 2004 Academic Article GET IT
Times cited: 76
Benzo[a]pyrene phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than benzo[a]pyrene glucuronides in cell lines derived from the human aerodigestive tract. Carcinogenesis. 2004 Academic Article GET IT
Times cited: 13

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Background

education and training

Ph.D., University of California, Berkeley 1963
B.Sc., Hebrew University (Israel) 1958

Contact

full name

Levy Kopelovich

primary email

lek2010@med.cornell.edu

VIVO Weill Cornell Medical College

Levy Kopelovich Adjunct Professor of Biochemistry in Medicine

Publications

selected publications

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Background

education and training

Contact

full name

primary email