Shi, Lei

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The LeuT-fold neurotransmitter:sodium symporter MhsT has two substrate sites. Proceedings of the National Academy of Sciences of the United States of America. 2018 Academic Article GET IT
Times cited: 14
Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance. Proceedings of the National Academy of Sciences of the United States of America. 2018 Academic Article GET IT
Times cited: 51
The Isomeric Preference of an Atypical Dopamine Transporter Inhibitor Contributes to Its Selection of the Transporter Conformation. ACS chemical neuroscience. 2017 Academic Article GET IT
Times cited: 21
The role of transmembrane segment 5 (TM5) in Na2 release and the conformational transition of neurotransmitter:sodium symporters toward the inward-open state. The Journal of biological chemistry. 2017 Academic Article GET IT
Times cited: 18
Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 48
Immunoproteasome β5i-Selective Dipeptidomimetic Inhibitors. ChemMedChem. 2016 Academic Article GET IT
Times cited: 26
Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu290. The Journal of biological chemistry. 2016 Academic Article GET IT
Times cited: 16
Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity. Journal of medicinal chemistry. 2016 Academic Article GET IT
Times cited: 29
Role of Annular Lipids in the Functional Properties of Leucine Transporter LeuT Proteomicelles. Biochemistry. 2016 Academic Article GET IT
Times cited: 11
Computational approaches to detect allosteric pathways in transmembrane molecular machines. Biochimica et biophysica acta. 2016 Academic Article GET IT
Times cited: 41
Substrate-induced unlocking of the inner gate determines the catalytic efficiency of a neurotransmitter:sodium symporter. The Journal of biological chemistry. 2015 Academic Article GET IT
Times cited: 29
Grafted biomembranes containing membrane proteins--the case of the leucine transporter. Soft matter. 2015 Academic Article GET IT
Times cited: 10
Discovery of a Novel Class of Negative Allosteric Modulator of the Dopamine D2 Receptor Through Fragmentation of a Bitopic Ligand. Journal of medicinal chemistry. 2015 Academic Article GET IT
Times cited: 45
Spontaneous inward opening of the dopamine transporter is triggered by PIP2-regulated dynamics of the N-terminus. ACS chemical neuroscience. 2015 Academic Article GET IT
Times cited: 78
Structural basis for Na(+)-sensitivity in dopamine D2 and D3 receptors. Chemical communications (Cambridge, England). 2015 Academic Article GET IT
Times cited: 23
Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters. The Journal of biological chemistry. 2015 Academic Article GET IT
Times cited: 40
Computational modeling of the N-terminus of the human dopamine transporter and its interaction with PIP2 -containing membranes. Proteins. 2015 Academic Article GET IT
Times cited: 39
The sodium/multivitamin transporter: a multipotent system with therapeutic implications. Vitamins and hormones. 2015 Review GET IT
Times cited: 25
What can crystal structures of aminergic receptors tell us about designing subtype-selective ligands?. Pharmacological reviews. 2015 Review GET IT
Times cited: 80
K303⁶·⁵⁸ in the μ opioid (MOP) receptor is important in conferring selectivity for covalent binding of β-funaltrexamine (β-FNA). European journal of pharmacology. 2014 Academic Article GET IT
Times cited: 5
Identification of a second substrate-binding site in solute-sodium symporters. The Journal of biological chemistry. 2014 Academic Article GET IT
Times cited: 15
A new mechanism of allostery in a G protein-coupled receptor dimer. Nature chemical biology. 2014 Academic Article GET IT
Times cited: 99
The second sodium site in the dopamine transporter controls cation permeation and is regulated by chloride. The Journal of biological chemistry. 2014 Academic Article GET IT
Times cited: 31
Missense dopamine transporter mutations associate with adult parkinsonism and ADHD. 2014 GET IT
Times cited: 103
Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D2 dopamine receptor. Molecular pharmacology. 2014 Academic Article GET IT
Times cited: 64
Conformational changes in dopamine transporter intracellular regions upon cocaine binding and dopamine translocation. Neurochemistry international. 2014 Academic Article GET IT
Times cited: 13
Elucidation of structural elements for selectivity across monoamine transporters: novel 2-[(diphenylmethyl)sulfinyl]acetamide (modafinil) analogues. Journal of medicinal chemistry. 2014 Academic Article GET IT
Times cited: 37
Beyond small-molecule SAR: using the dopamine D3 receptor crystal structure to guide drug design. Advances in pharmacology (San Diego, Calif.). 2014 Review GET IT
Times cited: 41
The sodium/proline transporter PutP of Helicobacter pylori. PloS one. 2013 Academic Article GET IT
Times cited: 11
Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells. The Journal of biological chemistry. 2013 Academic Article GET IT
Times cited: 132
A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors. Molecular pharmacology. 2013 Academic Article GET IT
Times cited: 49
The membrane protein LeuT in micellar systems: aggregation dynamics and detergent binding to the S2 site. Journal of the American Chemical Society. 2013 Academic Article GET IT
Times cited: 29
Chloride binding site of neurotransmitter sodium symporters. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 68
The cost of living in the membrane: a case study of hydrophobic mismatch for the multi-segment protein LeuT. Chemistry and physics of lipids. 2013 Academic Article GET IT
Times cited: 36
Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter. The Journal of biological chemistry. 2012 Academic Article GET IT
Times cited: 75
Ion-controlled conformational dynamics in the outward-open transition from an occluded state of LeuT. Biophysical journal. 2012 Academic Article GET IT
Times cited: 75
Molecular determinants of selectivity and efficacy at the dopamine D3 receptor. Journal of medicinal chemistry. 2012 Academic Article GET IT
Times cited: 142
R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse. Biological psychiatry. 2012 Academic Article GET IT
Times cited: 106
Experimental conditions can obscure the second high-affinity site in LeuT. Nature structural & molecular biology. 2012 Academic Article GET IT
Times cited: 77
Status of GPCR modeling and docking as reflected by community-wide GPCR Dock 2010 assessment. Structure (London, England : 1993). 2011 Academic Article GET IT
Times cited: 255
Conserved tyrosine in the first transmembrane segment of solute:sodium symporters is involved in Na+-coupled substrate co-transport. The Journal of biological chemistry. 2011 Academic Article GET IT
Times cited: 12
Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue. Nature. 2011 Academic Article GET IT
Times cited: 192
The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter. PloS one. 2011 Academic Article GET IT
Times cited: 101
Conformational rearrangements to the intracellular open states of the LeuT and ApcT transporters are modulated by common mechanisms. Biophysical journal. 2010 Academic Article GET IT
Times cited: 40
Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist. Science (New York, N.Y.). 2010 Academic Article GET IT
Times cited: 983
The binding sites for benztropines and dopamine in the dopamine transporter overlap. Neuropharmacology. 2010 Academic Article GET IT
Times cited: 55
Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters. Nature structural & molecular biology. 2010 Academic Article GET IT
Times cited: 158
Single-molecule dynamics of gating in a neurotransmitter transporter homologue. Nature. 2010 Academic Article GET IT
Times cited: 208
Substrate-dependent proton antiport in neurotransmitter:sodium symporters. Nature chemical biology. 2009 Academic Article GET IT
Times cited: 42
Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation. Proceedings of the National Academy of Sciences of the United States of America. 2009 Academic Article GET IT
Times cited: 148
A juxtamembrane mutation in the N terminus of the dopamine transporter induces preference for an inward-facing conformation. Molecular pharmacology. 2008 Academic Article GET IT
Times cited: 61
Dopamine D2 receptors form higher order oligomers at physiological expression levels. The EMBO journal. 2008 Academic Article GET IT
Times cited: 289
The binding sites for cocaine and dopamine in the dopamine transporter overlap. Nature neuroscience. 2008 Academic Article GET IT
Times cited: 271
The mechanism of a neurotransmitter:sodium symporter--inward release of Na+ and substrate is triggered by substrate in a second binding site. Molecular cell. 2008 Academic Article GET IT
Times cited: 307
An intracellular interaction network regulates conformational transitions in the dopamine transporter. The Journal of biological chemistry. 2008 Academic Article GET IT
Times cited: 108
Structural signatures and membrane helix 4 in GLUT1: inferences from human blood-brain glucose transport mutants. The Journal of biological chemistry. 2008 Academic Article GET IT
Times cited: 43
A comprehensive structure-based alignment of prokaryotic and eukaryotic neurotransmitter/Na+ symporters (NSS) aids in the use of the LeuT structure to probe NSS structure and function. Molecular pharmacology. 2006 Academic Article GET IT
Times cited: 233
State-dependent conformations of the translocation pathway in the tyrosine transporter Tyt1, a novel neurotransmitter:sodium symporter from Fusobacterium nucleatum. The Journal of biological chemistry. 2006 Academic Article GET IT
Times cited: 81
SNOSID, a proteomic method for identification of cysteine S-nitrosylation sites in complex protein mixtures. Proceedings of the National Academy of Sciences of the United States of America. 2006 Academic Article GET IT
Times cited: 299
A role for information collection, management, and integration in structure-function studies of G-protein coupled receptors. Current pharmaceutical design. 2006 Review GET IT
Times cited: 8
Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation. Proceedings of the National Academy of Sciences of the United States of America. 2005 Academic Article GET IT
Times cited: 252
A pincer-like configuration of TM2 in the human dopamine transporter is responsible for indirect effects on cocaine binding. Neuropharmacology. 2005 Academic Article GET IT
Times cited: 38
Crooked tail (Cd) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6. Proceedings of the National Academy of Sciences of the United States of America. 2005 Academic Article GET IT
Times cited: 84
Pseudomonas aeruginosa SoxR does not conform to the archetypal paradigm for SoxR-dependent regulation of the bacterial oxidative stress adaptive response. Infection and immunity. 2005 Academic Article GET IT
Times cited: 96
Building a protein name dictionary from full text: a machine learning term extraction approach. BMC bioinformatics. 2005 Academic Article GET IT
Times cited: 22
Comparison of the amino acid residues in the sixth transmembrane domains accessible in the binding-site crevices of mu, delta, and kappa opioid receptors. Biochemistry. 2001 Academic Article GET IT
Times cited: 30
The fourth transmembrane segment of the dopamine D2 receptor: accessibility in the binding-site crevice and position in the transmembrane bundle. Biochemistry. 2000 Academic Article GET IT
Times cited: 63

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Background

education and training

Ph.D., Columbia University 2002
B.S., Beijing University (China) 1996

Contact

full name

Lei Shi

primary email

les2007@med.cornell.edu

VIVO Weill Cornell Medical College

Lei Shi Assistant Professor of Physiology and Biophysics (Courtesy)

Publications

selected publications

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Background

education and training

Contact

full name

primary email