Mosconi, Lisa

Publications

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selected publications

A tale of two systems: Lessons learned from female mid-life aging with implications for Alzheimer's prevention & treatment. Ageing research reviews. 2021 Review GET IT
Times cited: 9
Association of Reproductive History With Brain MRI Biomarkers of Dementia Risk in Midlife. Neurology. 2021 Academic Article GET IT
Times cited: 16
Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition. Scientific reports. 2021 Academic Article GET IT
Times cited: 45
Safety and target engagement profile of two oxaloacetate doses in Alzheimer's patients. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2020 Academic Article GET IT
Times cited: 9
Sex-driven modifiers of Alzheimer risk: A multimodality brain imaging study. Neurology. 2020 Academic Article GET IT
Times cited: 56
Sex and Gender Driven Modifiers of Alzheimer's: The Role for Estrogenic Control Across Age, Race, Medical, and Lifestyle Risks. Frontiers in aging neuroscience. 2019 Review GET IT
Times cited: 109
Individualized clinical management of patients at risk for Alzheimer's dementia. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2019 Academic Article GET IT
Times cited: 38
Sleep oscillation-specific associations with Alzheimer's disease CSF biomarkers: novel roles for sleep spindles and tau. Molecular neurodegeneration. 2019 Academic Article GET IT
Times cited: 46
Increased Alzheimer's risk during the menopause transition: A 3-year longitudinal brain imaging study. PloS one. 2018 Academic Article GET IT
Times cited: 81
Associations of lifestyle and vascular risk factors with Alzheimer's brain biomarker changes during middle age: a 3-year longitudinal study in the broader New York City area. BMJ open. 2018 Academic Article GET IT
Times cited: 23
The clinical practice of risk reduction for Alzheimer's disease: A precision medicine approach. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2018 Academic Article GET IT
Times cited: 46
Utility of the NIH Toolbox for assessment of prodromal Alzheimer's disease and dementia. Alzheimer's & dementia (Amsterdam, Netherlands). 2018 Academic Article GET IT
Times cited: 23
How would we combat menopause as an Alzheimer's risk factor?. Expert review of neurotherapeutics. 2018 Editorial Article GET IT
Times cited: 7
Precision Medicine for Alzheimer's Disease Prevention. Healthcare (Basel, Switzerland). 2018 Review GET IT
Times cited: 380
Using social media to disseminate education about Alzheimer's prevention & treatment: a pilot study on Alzheimer's universe (www.AlzU.org). Journal of communication in healthcare. 2018 Academic Article GET IT
Times cited: 10
Mediterranean diet and 3-year Alzheimer brain biomarker changes in middle-aged adults. Neurology. 2018 Academic Article GET IT
Times cited: 103
Mechanisms of Risk Reduction in the Clinical Practice of Alzheimer's Disease Prevention. Frontiers in aging neuroscience. 2018 Review GET IT
Times cited: 836
Obstructive Sleep Apnea Severity Affects Amyloid Burden in Cognitively Normal Elderly. A Longitudinal Study. American journal of respiratory and critical care medicine. 2018 Academic Article GET IT
Times cited: 133
Lifestyle and vascular risk effects on MRI-based biomarkers of Alzheimer's disease: a cross-sectional study of middle-aged adults from the broader New York City area. BMJ open. 2018 Academic Article GET IT
Times cited: 46
Correction: Perimenopause and emergence of an Alzheimer's bioenergetic phenotype in brain and periphery. PloS one. 2018 Academic Article GET IT
Times cited: 10
Clinical Application of APOE in Alzheimer's Prevention: A Precision Medicine Approach. The journal of prevention of Alzheimer's disease. 2018 Review GET IT
Times cited: 29
Female Sex and Alzheimer's Risk: The Menopause Connection. The journal of prevention of Alzheimer's disease. 2018 Review GET IT
Times cited: 97
Perimenopause and emergence of an Alzheimer's bioenergetic phenotype in brain and periphery. PloS one. 2017 Academic Article GET IT
Times cited: 80
Sex differences in Alzheimer risk: Brain imaging of endocrine vs chronologic aging. Neurology. 2017 Academic Article GET IT
Times cited: 129
Reduced Slow-Wave Sleep Is Associated with High Cerebrospinal Fluid Aβ42 Levels in Cognitively Normal Elderly. Sleep. 2016 Academic Article GET IT
Times cited: 105
Transient and chronic seizure-induced inflammation in human focal epilepsy. 2016 GET IT
Times cited: 42
Dissociation of Down syndrome and Alzheimer's disease effects with imaging. Alzheimer's & dementia (New York, N. Y.). 2016 Academic Article GET IT
Times cited: 42
Orexin-A is Associated with Increases in Cerebrospinal Fluid Phosphorylated-Tau in Cognitively Normal Elderly Subjects. Sleep. 2016 Academic Article GET IT
Times cited: 36
Effects of vascular risk factors, statins, and antihypertensive drugs on PiB deposition in cognitively normal subjects. Alzheimer's & dementia (Amsterdam, Netherlands). 2016 Academic Article GET IT
Times cited: 23
Let Food Be Thy Medicine: Diet, Nutrition, and Biomarkers' Risk of Alzheimer's Disease. Current nutrition reports. 2015 Academic Article GET IT
Times cited: 15
Sleep-disordered breathing advances cognitive decline in the elderly. Neurology. 2015 Academic Article GET IT
Times cited: 269
Nutrient patterns and brain biomarkers of Alzheimer's disease in cognitively normal individuals. The journal of nutrition, health & aging. 2015 Academic Article GET IT
Times cited: 108
Cortical laminar binding of PET amyloid and tau tracers in Alzheimer disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2015 Academic Article GET IT
Times cited: 19
Periodontal disease associates with higher brain amyloid load in normal elderly. Neurobiology of aging. 2014 Academic Article GET IT
Times cited: 164
Reduced retention of Pittsburgh compound B in white matter lesions. European journal of nuclear medicine and molecular imaging. 2014 Academic Article GET IT
Times cited: 25
Physical Activity, Mediterranean Diet and Biomarkers-Assessed Risk of Alzheimer's: A Multi-Modality Brain Imaging Study. Advances in molecular imaging. 2014 Academic Article GET IT
Times cited: 30
Reduced glucose uptake and Aβ in brain regions with hyperintensities in connected white matter. NeuroImage. 2014 Academic Article GET IT
Times cited: 21
Nutrient intake and brain biomarkers of Alzheimer's disease in at-risk cognitively normal individuals: a cross-sectional neuroimaging pilot study. BMJ open. 2014 Academic Article GET IT
Times cited: 64
Mediterranean Diet and Magnetic Resonance Imaging-Assessed Brain Atrophy in Cognitively Normal Individuals at Risk for Alzheimer's Disease. The journal of prevention of Alzheimer's disease. 2014 Academic Article GET IT
A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2014 Review GET IT
Times cited: 1510
Brain: normal variations and benign findings in fluorodeoxyglucose-PET/computed tomography imaging. PET clinics. 2014 Review GET IT
Times cited: 83
FDG and Amyloid PET in Cognitively Normal Individuals at Risk for Late-Onset Alzheimer's Disease. Advances in molecular imaging. 2014 Academic Article GET IT
Times cited: 82
Brain imaging of cognitively normal individuals with 2 parents affected by late-onset AD. Neurology. 2014 Academic Article GET IT
Times cited: 45
Interaction between sleep-disordered breathing and apolipoprotein E genotype on cerebrospinal fluid biomarkers for Alzheimer's disease in cognitively normal elderly individuals. Neurobiology of aging. 2013 Academic Article GET IT
Times cited: 92
Imaging and cerebrospinal fluid biomarkers in the search for Alzheimer's disease mechanisms. Neuro-degenerative diseases. 2013 Academic Article GET IT
Times cited: 9
Blood pressure decrease correlates with tau pathology and memory decline in hypertensive elderly. Neurobiology of aging. 2013 Academic Article GET IT
Times cited: 56
Glucose metabolism in normal aging and Alzheimer's disease: Methodological and physiological considerations for PET studies. Clinical and translational imaging. 2013 Academic Article GET IT
Times cited: 188
Cerebrospinal fluid biomarkers of Alzheimer's disease in healthy elderly. Frontiers in bioscience (Landmark edition). 2013 Review GET IT
Times cited: 18
Posterior cingulate glucose metabolism, hippocampal glucose metabolism, and hippocampal volume in cognitively normal, late-middle-aged persons at 3 levels of genetic risk for Alzheimer disease. JAMA neurology. 2013 Academic Article GET IT
Times cited: 1975
Comparing brain amyloid deposition, glucose metabolism, and atrophy in mild cognitive impairment with and without a family history of dementia. Journal of Alzheimer's disease : JAD. 2013 Academic Article GET IT
Times cited: 33
Alternative normalization methods demonstrate widespread cortical hypometabolism in untreated de novo Parkinson's disease. The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of.... 2012 Academic Article GET IT
Times cited: 14
Amyloid and metabolic positron emission tomography imaging of cognitively normal adults with Alzheimer's parents. Neurobiology of aging. 2012 Academic Article GET IT
Times cited: 47
Brain amyloid imaging: the challenge of the third millennium. The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of.... 2011 Article GET IT
FDG- and amyloid-PET in Alzheimer's disease: is the whole greater than the sum of the parts?. The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of.... 2011 Review GET IT
Times cited: 35
PET/CT in diagnosis of dementia. Annals of the New York Academy of Sciences. 2011 Review GET IT
Times cited: 59
PET/CT in diagnosis of movement disorders. Annals of the New York Academy of Sciences. 2011 Review GET IT
Times cited: 45
The concept of FDG-PET endophenotype in Alzheimer's disease. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2011 Review GET IT
Times cited: 10
Alzheimer's disease markers, hypertension, and gray matter damage in normal elderly. Neurobiology of aging. 2011 Academic Article GET IT
Times cited: 53
Maternal age affects brain metabolism in adult children of mothers affected by Alzheimer's disease. Neurobiology of aging. 2011 Academic Article GET IT
Times cited: 9
Structural brain changes in normal individuals with a maternal history of Alzheimer's. Neurobiology of aging. 2011 Academic Article GET IT
Times cited: 48
Reduced mitochondria cytochrome oxidase activity in adult children of mothers with Alzheimer's disease. Journal of Alzheimer's disease : JAD. 2011 Academic Article GET IT
Times cited: 76
Oxidative stress and amyloid-beta pathology in normal individuals with a maternal history of Alzheimer's. Biological psychiatry. 2010 Academic Article GET IT
Times cited: 41
Framingham cardiovascular risk profile correlates with impaired hippocampal and cortical vasoreactivity to hypercapnia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2010 Academic Article GET IT
Times cited: 55
Evaluation of Early Dementia (Mild Cognitive Impairment). PET clinics. 2010 Review GET IT
Times cited: 4
Increased fibrillar amyloid-{beta} burden in normal individuals with a family history of late-onset Alzheimer's. Proceedings of the National Academy of Sciences of the United States of America. 2010 Academic Article GET IT
Times cited: 115
Early detection of Alzheimer's disease with PET imaging. Neuro-degenerative diseases. 2010 Review GET IT
Times cited: 44
Phosphorylated tau 231, memory decline and medial temporal atrophy in normal elders. Neurobiology of aging. 2010 Academic Article GET IT
Times cited: 37
Maternal transmission of Alzheimer's disease: prodromal metabolic phenotype and the search for genes. Human genomics. 2010 Review GET IT
Times cited: 73
Pre-clinical detection of Alzheimer's disease using FDG-PET, with or without amyloid imaging. Journal of Alzheimer's disease : JAD. 2010 Review GET IT
Times cited: 204
Current Challenges for the Early Detection of Alzheimer's Disease: Brain Imaging and CSF Studies. Journal of clinical neurology (Seoul, Korea). 2009 Academic Article GET IT
Times cited: 69
Differences in hippocampal metabolism between amnestic and non-amnestic MCI subjects: automated FDG-PET image analysis. The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of.... 2009 Academic Article GET IT
Times cited: 39
An entorhinal cortex sulcal pattern is associated with Alzheimer's disease. Human brain mapping. 2009 Academic Article GET IT
Times cited: 12
FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer's disease. European journal of nuclear medicine and molecular imaging. 2009 Academic Article GET IT
Times cited: 350
Effects of memantine on cerebrospinal fluid biomarkers of neurofibrillary pathology. Journal of Alzheimer's disease : JAD. 2009 Academic Article GET IT
Times cited: 7
Magnetic resonance imaging improves cerebrospinal fluid biomarkers in the early detection of Alzheimer's disease. Journal of Alzheimer's disease : JAD. 2009 Academic Article GET IT
Times cited: 53
Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease. Annals of the New York Academy of Sciences. 2008 Review GET IT
Times cited: 417
Declining brain glucose metabolism in normal individuals with a maternal history of Alzheimer disease. Neurology. 2008 Academic Article GET IT
Times cited: 154
Subregional hippocampal atrophy predicts Alzheimer's dementia in the cognitively normal. Neurobiology of aging. 2008 Academic Article GET IT
Times cited: 231
Positron emission tomography scans obtained for the evaluation of cognitive dysfunction. Seminars in nuclear medicine. 2008 Review GET IT
Times cited: 40
Robust and conventional neuropsychological norms: diagnosis and prediction of age-related cognitive decline. Neuropsychology. 2008 Academic Article GET IT
Times cited: 65
Regional analysis of FDG and PIB-PET images in normal aging, mild cognitive impairment, and Alzheimer's disease. European journal of nuclear medicine and molecular imaging. 2008 Academic Article GET IT
Times cited: 236
Individual cerebral metabolic deficits in Alzheimer's disease and amnestic mild cognitive impairment: an FDG PET study. 2008 GET IT
Times cited: 87
Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2008 Academic Article GET IT
Times cited: 548
The pre-mild cognitive impairment, subjective cognitive impairment stage of Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2008 Review GET IT
Times cited: 215
Longitudinal CSF isoprostane and MRI atrophy in the progression to AD. Journal of neurology. 2007 Academic Article GET IT
Times cited: 76
Maternal family history of Alzheimer's disease predisposes to reduced brain glucose metabolism. Proceedings of the National Academy of Sciences of the United States of America. 2007 Academic Article GET IT
Times cited: 199
The effects of normal aging and ApoE genotype on the levels of CSF biomarkers for Alzheimer's disease. Neurobiology of aging. 2007 Academic Article GET IT
Times cited: 66
Prediction and longitudinal study of CSF biomarkers in mild cognitive impairment. Neurobiology of aging. 2007 Academic Article GET IT
Times cited: 155
Hypometabolism and altered cerebrospinal fluid markers in normal apolipoprotein E E4 carriers with subjective memory complaints. Biological psychiatry. 2007 Academic Article GET IT
Times cited: 197
(18)F-FDG PET database of longitudinally confirmed healthy elderly individuals improves detection of mild cognitive impairment and Alzheimer's disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2007 Academic Article GET IT
Times cited: 59
Quantitation, regional vulnerability, and kinetic modeling of brain glucose metabolism in mild Alzheimer's disease. European journal of nuclear medicine and molecular imaging. 2007 Academic Article GET IT
Times cited: 40
Metabolic correlates of executive dysfunction. Different patterns in mild and very mild Alzheimer's disease. Journal of neurology. 2007 Academic Article GET IT
Times cited: 29
Prefrontal N-acetylaspartate and poststroke recovery: a longitudinal proton spectroscopy study. AJNR. American journal of neuroradiology. 2007 Academic Article GET IT
Times cited: 22
A non-toxic ligand for voxel-based MRI analysis of plaques in AD transgenic mice. Neurobiology of aging. 2007 Academic Article GET IT
Times cited: 56
Imaging and CSF studies in the preclinical diagnosis of Alzheimer's disease. Annals of the New York Academy of Sciences. 2007 Review GET IT
Times cited: 175
Seeing what Alzheimer saw. Nature medicine. 2007 Article GET IT
Times cited: 10
Hippocampal hypometabolism predicts cognitive decline from normal aging. Neurobiology of aging. 2007 Academic Article GET IT
Times cited: 265
Hypometabolism exceeds atrophy in presymptomatic early-onset familial Alzheimer's disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2006 Academic Article GET IT
Times cited: 247
Early detection of Alzheimer's disease using neuroimaging. Experimental gerontology. 2006 Review GET IT
Times cited: 135
Visual rating of medial temporal lobe metabolism in mild cognitive impairment and Alzheimer's disease using FDG-PET. European journal of nuclear medicine and molecular imaging. 2005 Academic Article GET IT
Times cited: 71
The role of quantitative structural imaging in the early diagnosis of Alzheimer's disease. Neuroimaging clinics of North America. 2005 Review GET IT
Times cited: 38
Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment. Neurobiology of aging. 2005 Academic Article GET IT
Times cited: 234
Reduced hippocampal metabolism in MCI and AD: automated FDG-PET image analysis. Neurology. 2005 Academic Article GET IT
Times cited: 303
Brain glucose metabolism in the early and specific diagnosis of Alzheimer's disease. FDG-PET studies in MCI and AD. European journal of nuclear medicine and molecular imaging. 2005 Review GET IT
Times cited: 683
Metabolic interaction between ApoE genotype and onset age in Alzheimer's disease: implications for brain reserve. Journal of neurology, neurosurgery, and psychiatry. 2005 Academic Article GET IT
Times cited: 55
Toward the validation of functional neuroimaging as a potential biomarker for Alzheimer's disease: implications for drug development. Molecular imaging and biology. 2005 Review GET IT
Times cited: 14
MCI conversion to dementia and the APOE genotype: a prediction study with FDG-PET. Neurology. 2004 Academic Article GET IT
Times cited: 322
Magnetic resonance and PET studies in the early diagnosis of Alzheimer's disease. Expert review of neurotherapeutics. 2004 Review GET IT
Times cited: 34
Brain metabolic decreases related to the dose of the ApoE e4 allele in Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. 2004 Academic Article GET IT
Times cited: 79
Functional interactions of the entorhinal cortex: an 18F-FDG PET study on normal aging and Alzheimer's disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2004 Academic Article GET IT
Times cited: 74
Age and ApoE genotype interaction in Alzheimer's disease: an FDG-PET study. Psychiatry research. 2004 Academic Article GET IT
Times cited: 40
Brain metabolic differences between sporadic and familial Alzheimer's disease. Neurology. 2003 Academic Article GET IT
Times cited: 24

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Research

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Funding awarded

New PET/CT System for Human and Non-human Primate Imaging awarded by National Institutes of Health, Office of the Director Key Personnel 2023 - 2024
Major Cyclotron Upgrades and Refurbishment awarded by National Institutes of Health, Office of the Director Key Personnel 2021 - 2023

PhytoSERM Efficacy to Prevent Menopause Associated Decline in Brain Metabolism and Cognition: A Double-Blind, Randomized, Placebo-Controlled Phase 2 Clinical Trial awarded by National Institute on Aging Principal Investigator Subaward 2022 - 2027
Perimenopause in Brain Aging and Alzheimer''s disease awarded by National Institute on Aging Principal Investigator Subaward 2021 - 2026
Sex Differences in the Molecular Determinants of Alzheimer’s Disease Risk awarded by National Institute on Aging Principal Investigator Subaward 2018 - 2024
Modifiable cardiovascular factors linking type 2 diabetes and Alzheimer''s awarded by Defense Advanced Research Projects Agency (DARPA) Principal Investigator Subaward 2018 - 2024
Sex Differences in the Molecular Determinants of Alzheimer''s Disease Risk: Prodromal Endophenotype awarded by National Institute on Aging Principal Investigator Subaward 2019 - 2023

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Background

education and training

Ph.D., University of Florence (Italy) 2006
M.Sc., University of Florence (Italy) 2001

Contact

full name

Lisa Mosconi

primary email

lim2035@med.cornell.edu

VIVO Weill Cornell Medical College

Lisa Mosconi Associate Professor of Neuroscience in Neurology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email