selected publications
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In vivo characterization of sAC null sperm.
Frontiers in cell and developmental biology.
2023
Academic Article
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Times cited: 120 -
On-demand male contraception via acute inhibition of soluble adenylyl cyclase.
Nature communications.
2023
Academic Article
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Times cited: 5 -
Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates.
Journal of medicinal chemistry.
2022
Academic Article
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Times cited: 4 -
Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization.
Molecular human reproduction.
2021
Academic Article
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Times cited: 12 -
Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10).
ACS medicinal chemistry letters.
2021
Academic Article
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Times cited: 8 -
Metabolic changes in mouse sperm during capacitation†.
Biology of reproduction.
2020
Academic Article
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Times cited: 34 -
Capacitation increases glucose consumption in murine sperm.
Molecular reproduction and development.
2020
Academic Article
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Times cited: 17 -
Molecular Mechanism Underlying the Action of Zona-pellucida Glycoproteins on Mouse Sperm.
Frontiers in cell and developmental biology.
2020
Academic Article
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Times cited: 178 -
Optimization of lead compounds into on-demand, nonhormonal contraceptives: leveraging a public-private drug discovery institute collaboration†.
Biology of reproduction.
2020
Academic Article
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Times cited: 13 -
Using an Extracellular Flux Analyzer to Measure Changes in Glycolysis and Oxidative Phosphorylation during Mouse Sperm Capacitation.
Journal of visualized experiments : JoVE.
2020
Academic Article
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Times cited: 5 -
A novel cross-species inhibitor to study the function of CatSper Ca2+ channels in sperm.
British journal of pharmacology.
2018
Academic Article
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Times cited: 42 -
Shedding light on the role of cAMP in mammalian sperm physiology.
Molecular and cellular endocrinology.
2017
Review
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Times cited: 34 -
Intracellular activation of ovastacin mediates pre-fertilization hardening of the zona pellucida.
Molecular human reproduction.
2017
Academic Article
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Times cited: 23 -
Re-visiting the Protamine-2 locus: deletion, but not haploinsufficiency, renders male mice infertile.
Scientific reports.
2016
Academic Article
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Times cited: 33 -
A novel biosensor to study cAMP dynamics in cilia and flagella.
eLife.
2016
Academic Article
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Times cited: 61 -
Targeted inactivation of the mouse epididymal beta-defensin 41 alters sperm flagellar beat pattern and zona pellucida binding.
Molecular and cellular endocrinology.
2016
Academic Article
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Times cited: 22 -
Controlling fertilization and cAMP signaling in sperm by optogenetics.
eLife.
2015
Academic Article
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Times cited: 77 -
Direct action of endocrine disrupting chemicals on human sperm.
EMBO reports.
2014
Academic Article
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Times cited: 118