Kluk, Michael J.

Publications

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selected publications

Molecular profiling of the stroke-induced alterations in the cerebral microvasculature reveals promising therapeutic candidates. Proceedings of the National Academy of Sciences of the United States of America. 2023 Academic Article GET IT
Current Landscape of Ancillary Diagnostic Testing in Chronic Lymphocytic Leukemia. Surgical pathology clinics. 2023 Review GET IT
Clinicopathologic characteristics of myeloproliferative neoplasms with JAK2 exon 12 mutation. Leukemia research. 2023 Academic Article GET IT
Acute hemolytic anemia after hematopoietic stem cell transplantation: An unusual invader. 2023 GET IT
A FOXO1-dependent transcription network is a targetable vulnerability of mantle cell lymphomas. The Journal of clinical investigation. 2022 Academic Article GET IT
Times cited: 1
A novel SF3B1 variant in a patient with MDS with ring sideroblasts. EJHaem. 2022 Academic Article GET IT
Successful treatment and integrated genomic analysis of an infant with FIP1L1-RARA fusion-associated myeloid neoplasm. 2022 GET IT
Times cited: 4
Comparison of Multiple Clinical Testing Modalities for Assessment of NPM1-Mutant AML. Frontiers in oncology. 2021 Academic Article GET IT
Times cited: 103
Clinical Laboratory Validation and Implementation of Quantitative, Real-Time PCR-based Detection of NPM1 Type A Mutation. Clinical laboratory. 2020 Academic Article GET IT
Times cited: 1
NPM1 Biology in Myeloid Neoplasia. Current hematologic malignancy reports. 2020 Review GET IT
Times cited: 6
Evaluation of S1PR1, pSTAT3, S1PR2, FOXP1 Expression in Aggressive, Mature B Cell Lymphomas. Journal of hematopathology. 2019 Academic Article GET IT
Times cited: 3
Expedited Analysis and Reporting of Multiple Mutations that Modify Medical Management of Myeloid Malignancies: It's About (Turnaround) Time!. The Journal of molecular diagnostics : JMD. 2018 Comment GET IT
A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas. Cell reports. 2017 Academic Article GET IT
Times cited: 51
MRD in AML: a role for detecting leukemic blasts at day 14 post-induction chemotherapy?. Leukemia & lymphoma. 2017 Comment GET IT
The cancer precision medicine knowledge base for structured clinical-grade mutations and interpretations. Journal of the American Medical Informatics Association : JAMIA. 2017 Academic Article GET IT
Times cited: 72
Utility of Genomic Analysis in Differentiating Synchronous and Metachronous Lung Adenocarcinomas from Primary Adenocarcinomas with Intrapulmonary Metastasis. Translational oncology. 2017 Academic Article GET IT
Times cited: 35
Molecular Pathology: Predictive, Prognostic, and Diagnostic Markers in Lymphoid Neoplasms. Surgical pathology clinics. 2016 Review GET IT
Times cited: 4
Development and validation of a whole-exome sequencing test for simultaneous detection of point mutations, indels and copy-number alterations for precision cancer care. NPJ genomic medicine. 2016 Academic Article GET IT
Times cited: 58
Validation and Implementation of a Custom Next-Generation Sequencing Clinical Assay for Hematologic Malignancies. The Journal of molecular diagnostics : JMD. 2016 Academic Article GET IT
Times cited: 112
Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies. Oncogene. 2016 Academic Article GET IT
Times cited: 62
Rosai-Dorfman Disease Harboring an Activating KRAS K117N Missense Mutation. 2016 GET IT
Times cited: 53
An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma. Nature genetics. 2016 Academic Article GET IT
Times cited: 176
MYC Immunohistochemistry to Identify MYC-Driven B-Cell Lymphomas in Clinical Practice. American journal of clinical pathology. 2016 Academic Article GET IT
Times cited: 25
Complete hematologic response of early T-cell progenitor acute lymphoblastic leukemia to the γ-secretase inhibitor BMS-906024: genetic and epigenetic findings in an outlier case. Cold Spring Harbor molecular case studies. 2015 Academic Article GET IT
Myeloid neoplasm demonstrating a STAT5B-RARA rearrangement and genetic alterations associated with all-trans retinoic acid resistance identified by a custom next-generation sequencing assay. Cold Spring Harbor molecular case studies. 2015 Academic Article GET IT
Critical role of sphingosine-1-phosphate receptor-2 in the disruption of cerebrovascular integrity in experimental stroke. Nature communications. 2015 Academic Article GET IT
Times cited: 105
Age-related clonal hematopoiesis associated with adverse outcomes. The New England journal of medicine. 2014 Academic Article GET IT
Times cited: 2697
Molecular classification of MYC-driven B-cell lymphomas by targeted gene expression profiling of fixed biopsy specimens. The Journal of molecular diagnostics : JMD. 2014 Academic Article GET IT
Times cited: 21
Cyclin C is a haploinsufficient tumour suppressor. Nature cell biology. 2014 Academic Article GET IT
Times cited: 107
Prospective enterprise-level molecular genotyping of a cohort of cancer patients. The Journal of molecular diagnostics : JMD. 2014 Academic Article GET IT
Times cited: 65
Discovery of biomarkers predictive of GSI response in triple-negative breast cancer and adenoid cystic carcinoma. Cancer discovery. 2014 Academic Article GET IT
Times cited: 101
NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis. The Journal of investigative dermatology. 2014 Academic Article GET IT
Times cited: 251
The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells. Genes & development. 2014 Academic Article GET IT
Times cited: 44
An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia. Nature genetics. 2014 Academic Article GET IT
Times cited: 288
Detection of MYD88 L265P in peripheral blood of patients with Waldenström's Macroglobulinemia and IgM monoclonal gammopathy of undetermined significance. Leukemia. 2014 Academic Article GET IT
Times cited: 83
Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry. PloS one. 2013 Academic Article GET IT
Times cited: 87
Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation. Blood. 2013 Academic Article GET IT
Times cited: 123
MYC, a downstream target of BRD-NUT, is necessary and sufficient for the blockade of differentiation in NUT midline carcinoma. Oncogene. 2013 Academic Article GET IT
Times cited: 126
Sphingosine-1-phosphate receptor 1 in classical Hodgkin lymphoma: assessment of expression and role in cell migration. Laboratory investigation; a journal of technical methods and pathology. 2013 Academic Article GET IT
Times cited: 35
Acute myeloid leukemia and myelodysplastic syndromes after radiation therapy are similar to de novo disease and differ from other therapy-related myeloid neoplasms. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2012 Academic Article GET IT
Times cited: 80
Immunohistochemical detection of MYC-driven diffuse large B-cell lymphomas. PloS one. 2012 Academic Article GET IT
Times cited: 137
Polycomb repressive complex 2 is required for MLL-AF9 leukemia. Proceedings of the National Academy of Sciences of the United States of America. 2012 Academic Article GET IT
Times cited: 175
Dosing clopidogrel based on CYP2C19 genotype and the effect on platelet reactivity in patients with stable cardiovascular disease. JAMA. 2011 Academic Article GET IT
Times cited: 326
TCR-dependent transformation of mature memory phenotype T cells in mice. The Journal of clinical investigation. 2011 Academic Article GET IT
Times cited: 62
Avoiding pitfalls in molecular genetic testing: case studies of high-resolution array comparative genomic hybridization testing in the definitive diagnosis of Mowat-Wilson syndrome. 2011 GET IT
Times cited: 5
Genomic alterations in myeloid neoplasms with novel, apparently balanced translocations. 2011 GET IT
Times cited: 4
Carcinoma and multiple lymphomas in one patient: establishing the diagnoses and analyzing risk factors. Journal of hematopathology. 2009 Academic Article GET IT
Times cited: 85
Frequency of clinically occult intraepithelial and invasive neoplasia in reduction mammoplasty specimens: a study of 516 cases. International journal of surgical pathology. 2008 Academic Article GET IT
Times cited: 37
Successful treatment of malignant melanoma in situ with topical 5% imiquimod cream. 2005 GET IT
Times cited: 48
Melanoma on the move: the progression of melanoma: novel concepts with histologic correlates. The American Journal of dermatopathology. 2004 Review GET IT
Times cited: 8
Platelet-derived growth factor (PDGF)-induced chemotaxis does not require the G protein-coupled receptor S1P1 in murine embryonic fibroblasts and vascular smooth muscle cells. FEBS letters. 2003 Academic Article GET IT
Times cited: 33
Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. Biochimica et biophysica acta. 2002 Review GET IT
Times cited: 279
Lysophospholipids--receptor revelations. Science (New York, N.Y.). 2001 Review GET IT
Times cited: 482
Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration. Circulation research. 2001 Academic Article GET IT
Times cited: 152
Sphingosine-1-phosphate signaling via the EDG-1 family of G-protein-coupled receptors. Annals of the New York Academy of Sciences. 2000 Review GET IT
Times cited: 47
Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate. Cell. 1999 Academic Article GET IT
Times cited: 879
Sphingosine-1-phosphate: extracellular mediator or intracellular second messenger?. Biochemical pharmacology. 1999 Review GET IT
Times cited: 146

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Background

education and training

M.D., Ph.D., University of Connecticut School of Medicine 2004
B.A., University of Rochester 1995

Contact

full name

Michael J. Kluk

primary email

mik9095@med.cornell.edu

webpage

Clinical Profile

VIVO Weill Cornell Medical College

Michael J. Kluk Associate Professor of Clinical Pathology and Laboratory Medicine

Publications

selected publications

Background

education and training

Contact

full name

primary email

webpage