LeVine, Michael V

Publications

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selected publications

X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release. Nature communications. 2020 Academic Article GET IT
Times cited: 22
The allosteric mechanism of substrate-specific transport in SLC6 is mediated by a volumetric sensor. Proceedings of the National Academy of Sciences of the United States of America. 2019 Academic Article GET IT
Times cited: 18
A partially-open inward-facing intermediate conformation of LeuT is associated with Na⁺ release and substrate transport. Nature communications. 2018 Academic Article GET IT
Times cited: 31
Thermodynamic Coupling Function Analysis of Allosteric Mechanisms in the Human Dopamine Transporter. Biophysical journal. 2017 Academic Article GET IT
Times cited: 13
Ligand modulation of sidechain dynamics in a wild-type human GPCR. eLife. 2017 Academic Article GET IT
Times cited: 59
The Allostery Landscape: Quantifying Thermodynamic Couplings in Biomolecular Systems. Journal of chemical theory and computation. 2016 Academic Article GET IT
Times cited: 24
Allosteric Mechanisms of Molecular Machines at the Membrane: Transport by Sodium-Coupled Symporters. Chemical reviews. 2016 Review GET IT
Times cited: 57
Role of Annular Lipids in the Functional Properties of Leucine Transporter LeuT Proteomicelles. Biochemistry. 2016 Academic Article GET IT
Times cited: 11
Computational approaches to detect allosteric pathways in transmembrane molecular machines. Biochimica et biophysica acta. 2016 Academic Article GET IT
Times cited: 41
Spontaneous inward opening of the dopamine transporter is triggered by PIP2-regulated dynamics of the N-terminus. ACS chemical neuroscience. 2015 Academic Article GET IT
Times cited: 78
AIM for Allostery: Using the Ising Model to Understand Information Processing and Transmission in Allosteric Biomolecular Systems. Entropy (Basel, Switzerland). 2015 Academic Article GET IT
Times cited: 15
A functional selectivity mechanism at the serotonin-2A GPCR involves ligand-dependent conformations of intracellular loop 2. Journal of the American Chemical Society. 2014 Academic Article GET IT
Times cited: 60
NbIT--a new information theory-based analysis of allosteric mechanisms reveals residues that underlie function in the leucine transporter LeuT. PLoS computational biology. 2014 Academic Article GET IT
Times cited: 76
The membrane protein LeuT in micellar systems: aggregation dynamics and detergent binding to the S2 site. Journal of the American Chemical Society. 2013 Academic Article GET IT
Times cited: 29

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Background

education and training

Ph.D., Weill Cornell Graduate School of Medical Sciences 2016
B.A., Wesleyan University 2011

Contact

full name

Michael V LeVine

primary email

mil2037@med.cornell.edu

VIVO Weill Cornell Medical College

Michael V LeVine Assistant Professor of Computational Biophysics in Computational Biomedicine (Courtesy)

Publications

selected publications

Background

education and training

Contact

full name

primary email