Horner, Philip

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selected publications

Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes. Stem cell reports. 2017 Academic Article GET IT
Times cited: 60
Development of switchable polymers to address the dilemma of stability and cargo release in polycationic nucleic acid carriers. Biomaterials. 2017 Academic Article GET IT
Times cited: 43
Non-Viral Nucleic Acid Delivery Strategies to the Central Nervous System. Frontiers in molecular neuroscience. 2016 Review GET IT
Times cited: 111
Nano-Sized Sunflower Polycations As Effective Gene Transfer Vehicles. Small (Weinheim an der Bergstrasse, Germany). 2016 Academic Article GET IT
Times cited: 37
Targeted axonal import (TAxI) peptide delivers functional proteins into spinal cord motor neurons after peripheral administration. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 23
Microbubbles and ultrasound increase intraventricular polyplex gene transfer to the brain. Journal of controlled release : official journal of the Controlled Release Society. 2016 Academic Article GET IT
Times cited: 33
Early astrocyte redistribution in the optic nerve precedes axonopathy in the DBA/2J mouse model of glaucoma. Experimental eye research. 2015 Academic Article GET IT
Times cited: 59
A Cervical Hemi-Contusion Spinal Cord Injury Model for the Investigation of Novel Therapeutics Targeting Proximal and Distal Forelimb Functional Recovery. Journal of neurotrauma. 2015 Academic Article GET IT
Times cited: 30
Neural Stem Cells in the Adult Subventricular Zone Oxidize Fatty Acids to Produce Energy and Support Neurogenic Activity. Stem cells (Dayton, Ohio). 2015 Academic Article GET IT
Times cited: 89
Guanidinylated block copolymers for gene transfer: A comparison with amine-based materials for in vitro and in vivo gene transfer efficiency. Biomaterials. 2015 Academic Article GET IT
Times cited: 20
A functionalized, injectable hydrogel for localized drug delivery with tunable thermosensitivity: synthesis and characterization of physical and toxicological properties. Journal of controlled release : official journal of the Controlled Release Society. 2015 Academic Article GET IT
Times cited: 45
Mitochondrial morphology differences and mitophagy deficit in murine glaucomatous optic nerve. Investigative ophthalmology & visual science. 2015 Academic Article GET IT
Times cited: 81
MMP9-sensitive polymers mediate environmentally-responsive bivalirudin release and thrombin inhibition. Biomaterials science. 2015 Academic Article GET IT
Times cited: 17
Poly(lactic-co-glycolic) acid microspheres encapsulated in Pluronic F-127 prolong hirudin delivery and improve functional recovery from a demyelination lesion. Biomaterials. 2014 Academic Article GET IT
Times cited: 37
Differential progression of structural and functional alterations in distinct retinal ganglion cell types in a mouse model of glaucoma. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013 Academic Article GET IT
Times cited: 184
Caudalized human iPSC-derived neural progenitor cells produce neurons and glia but fail to restore function in an early chronic spinal cord injury model. Experimental neurology. 2013 Academic Article GET IT
Times cited: 74
The impact of age on oncogenic potential: tumor-initiating cells and the brain microenvironment. Aging cell. 2013 Review GET IT
Times cited: 19
α-Lipoic acid antioxidant treatment limits glaucoma-related retinal ganglion cell death and dysfunction. PloS one. 2013 Academic Article GET IT
Times cited: 101
Therapeutic intraspinal microstimulation improves forelimb function after cervical contusion injury. Journal of neural engineering. 2013 Academic Article GET IT
Times cited: 56
Dual responsive, stabilized nanoparticles for efficient in vivo plasmid delivery. Angewandte Chemie (International ed. in English). 2013 Academic Article GET IT
Times cited: 110
FMR1 transcript isoforms: association with polyribosomes; regional and developmental expression in mouse brain. PloS one. 2013 Academic Article GET IT
Times cited: 41
Remyelination reporter reveals prolonged refinement of spontaneously regenerated myelin. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 85
Melittin-grafted HPMA-oligolysine based copolymers for gene delivery. Biomaterials. 2012 Academic Article GET IT
Times cited: 58
Geropotency: increased malignant potential of aging neural progenitors. Aging. 2012 Editorial Article GET IT
Times cited: 4
Increased age of transformed mouse neural progenitor/stem cells recapitulates age-dependent clinical features of human glioma malignancy. Aging cell. 2012 Academic Article GET IT
Times cited: 10
Stem cell-based therapy for spinal cord injury. Cell transplantation. 2012 Review GET IT
Times cited: 49
Early reduction of microglia activation by irradiation in a model of chronic glaucoma. PloS one. 2012 Academic Article GET IT
Times cited: 109
Axonal thinning and extensive remyelination without chronic demyelination in spinal injured rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 Academic Article GET IT
Times cited: 62
Chondroitinase ABC combined with neurotrophin NT-3 secretion and NR2D expression promotes axonal plasticity and functional recovery in rats with lateral hemisection of the spinal cord. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 Academic Article GET IT
Times cited: 87
Increased re-entry into cell cycle mitigates age-related neurogenic decline in the murine subventricular zone. Stem cells (Dayton, Ohio). 2011 Academic Article GET IT
Times cited: 23
Combined delivery of Nogo-A antibody, neurotrophin-3 and the NMDA-NR2d subunit establishes a functional 'detour' in the hemisected spinal cord. The European journal of neuroscience. 2011 Academic Article GET IT
Times cited: 54
Aging neural progenitor cells have decreased mitochondrial content and lower oxidative metabolism. The Journal of biological chemistry. 2011 Academic Article GET IT
Times cited: 58
TWIST1 promotes invasion through mesenchymal change in human glioblastoma. Molecular cancer. 2010 Academic Article GET IT
Times cited: 214
Metabolic vulnerability disposes retinal ganglion cell axons to dysfunction in a model of glaucomatous degeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010 Academic Article GET IT
Times cited: 119
Distal axonopathy with structural persistence in glaucomatous neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America. 2010 Academic Article GET IT
Times cited: 265
Beta-catenin signaling increases in proliferating NG2+ progenitors and astrocytes during post-traumatic gliogenesis in the adult brain. Stem cells (Dayton, Ohio). 2010 Academic Article GET IT
Times cited: 61
Reply to: age as a predictive factor in glioblastomas: population-based study. Neuroepidemiology. 2010 Letter GET IT
Targeted nonviral delivery vehicles to neural progenitor cells in the mouse subventricular zone. Biomaterials. 2009 Academic Article GET IT
Times cited: 67
A syngeneic glioma model to assess the impact of neural progenitor target cell age on tumor malignancy. Aging cell. 2009 Academic Article GET IT
Times cited: 16
Postinjury niches induce temporal shifts in progenitor fates to direct lesion repair after spinal cord injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009 Academic Article GET IT
Times cited: 107
Drp1 levels constitutively regulate mitochondrial dynamics and cell survival in cortical neurons. Experimental neurology. 2009 Academic Article GET IT
Times cited: 78
Protection of hippocampal neurogenesis from toll-like receptor 4-dependent innate immune activation by ablation of prostaglandin E2 receptor subtype EP1 or EP2. The American journal of pathology. 2009 Academic Article GET IT
Times cited: 32
Age-related myelin dynamics revealed by increased oligodendrogenesis and short internodes. Aging cell. 2009 Academic Article GET IT
Times cited: 81
Quantitative analysis of mitotic Olig2 cells in adult human brain and gliomas: implications for glioma histogenesis and biology. Glia. 2009 Academic Article GET IT
Times cited: 40
Manganese-enhanced MRI of the DBA/2J mouse model of hereditary glaucoma. Investigative ophthalmology & visual science. 2008 Academic Article GET IT
Times cited: 50
No evidence for chronic demyelination in spared axons after spinal cord injury in a mouse. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 Academic Article GET IT
Times cited: 109
Reduced retina microglial activation and improved optic nerve integrity with minocycline treatment in the DBA/2J mouse model of glaucoma. Investigative ophthalmology & visual science. 2008 Academic Article GET IT
Times cited: 245
Progressive ganglion cell degeneration precedes neuronal loss in a mouse model of glaucoma. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 Academic Article GET IT
Times cited: 328
Retinal ganglion cells downregulate gene expression and lose their axons within the optic nerve head in a mouse glaucoma model. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 Academic Article GET IT
Times cited: 241
Adult spinal cord progenitor cells are repelled by netrin-1 in the embryonic and injured adult spinal cord. Proceedings of the National Academy of Sciences of the United States of America. 2007 Academic Article GET IT
Times cited: 32
Nonviral approaches for neuronal delivery of nucleic acids. Pharmaceutical research. 2007 Review GET IT
Times cited: 106
Neuron-specific delivery of nucleic acids mediated by Tet1-modified poly(ethylenimine). The journal of gene medicine. 2007 Academic Article GET IT
Times cited: 82
Reactive nonproliferative gliosis predominates in a chronic mouse model of glaucoma. Glia. 2007 Academic Article GET IT
Times cited: 153
Fate of endogenous stem/progenitor cells following spinal cord injury. The Journal of comparative neurology. 2006 Academic Article GET IT
Times cited: 217
Microarray analysis of retinal gene expression in the DBA/2J model of glaucoma. Investigative ophthalmology & visual science. 2006 Academic Article GET IT
Times cited: 182
Quantitative correlation of optic nerve pathology with ocular pressure and corneal thickness in the DBA/2 mouse model of glaucoma. Investigative ophthalmology & visual science. 2006 Academic Article GET IT
Times cited: 107
Instructive niches: environmental instructions that confound NG2 proteoglycan expression and the fate-restriction of CNS progenitors. Journal of anatomy. 2005 Review GET IT
Times cited: 20
Combined delivery of neurotrophin-3 and NMDA receptors 2D subunit strengthens synaptic transmission in contused and staggered double hemisected spinal cord of neonatal rat. Experimental neurology. 2005 Academic Article GET IT
Times cited: 31
Environmental enrichment increases progenitor cell survival in the dentate gyrus following lateral fluid percussion injury. Brain research. Molecular brain research. 2005 Academic Article GET IT
Times cited: 52
Pharmacologic suppression of neuronal oxidative damage and dendritic degeneration following direct activation of glial innate immunity in mouse cerebrum. Journal of neurochemistry. 2003 Academic Article GET IT
Times cited: 89
New roles for astrocytes: the nightlife of an 'astrocyte'. La vida loca!. Trends in neurosciences. 2003 Review GET IT
Times cited: 101
Chronic neurotrophin-3 strengthens synaptic connections to motoneurons in the neonatal rat. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2003 Academic Article GET IT
Times cited: 38
A conditional deletion of the NR1 subunit of the NMDA receptor in adult spinal cord dorsal horn reduces NMDA currents and injury-induced pain. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2003 Academic Article GET IT
Times cited: 164
Regeneration in the adult and aging brain. Archives of neurology. 2002 Editorial Article GET IT
Times cited: 30
Expression of IL-17B in neurons and evaluation of its possible role in the chromosome 5q-linked form of Charcot-Marie-Tooth disease. Neuromuscular disorders : NMD. 2002 Academic Article GET IT
Times cited: 45
Potent possibilities: endogenous stem cells in the adult spinal cord. Progress in brain research. 2002 Review GET IT
Times cited: 8
Adult spinal cord stem cells generate neurons after transplantation in the adult dentate gyrus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2000 Academic Article GET IT
Times cited: 596
Regenerating the damaged central nervous system. Nature. 2000 Academic Article GET IT
Times cited: 694
Proliferation and differentiation of progenitor cells throughout the intact adult rat spinal cord. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2000 Academic Article GET IT
Times cited: 698
Neurotrophin-3 and brain-derived neurotrophic factor induce oligodendrocyte proliferation and myelination of regenerating axons in the contused adult rat spinal cord. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1998 Academic Article GET IT
Times cited: 515
A quantitative spatial analysis of the blood-spinal cord barrier. I. Permeability changes after experimental spinal contusion injury. Experimental neurology. 1996 Academic Article GET IT
Times cited: 222
A quantitative spatial analysis of the blood-spinal cord barrier. II. Permeability after intraspinal fetal transplantation. Experimental neurology. 1996 Academic Article GET IT
Times cited: 13
Quantitative analysis of vascularization and cytochrome oxidase following fetal transplantation in the contused rat spinal cord. The Journal of comparative neurology. 1996 Academic Article GET IT
Times cited: 19
Fetal transplantation following spinal contusion injury results in chronic alterations in CNS glucose metabolism. Experimental neurology. 1995 Academic Article GET IT
Times cited: 12
N-acetyl-GRP(20-26)-O-CH3 reverses intracisternal bombesin-induced inhibition of gastric acid secretion in rats. Peptides. 1991 Academic Article GET IT
Times cited: 9

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Background

education and training

Ph.D., Ohio State University 1995
M.S., Ohio State University 1992
B.S., University of Nevada 1988

Contact

full name

Philip Horner

primary email

pjh2008@med.cornell.edu

VIVO Weill Cornell Medical College

Philip Horner Professor of Physiology in Neurological Surgery

Publications

selected publications

Background

education and training

Contact

full name

primary email