Ratan, Rajiv R.

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selected publications

The drug adaptaquin blocks ATF4/CHOP-dependent pro-death Trib3 induction and protects in cellular and mouse models of Parkinson's disease. Neurobiology of disease. 2020 Academic Article GET IT
Times cited: 32
Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke. Cell. 2019 Academic Article GET IT
Times cited: 445
Ferroptosis in Neurons and Cancer Cells Is Similar But Differentially Regulated by Histone Deacetylase Inhibitors. eNeuro. 2019 Academic Article GET IT
Times cited: 48
Protecting and repairing the brain: central and peripheral strategies define the New Rehabilitation following traumatic brain injury. Current opinion in neurology. 2018 Editorial Article GET IT
Times cited: 2
Arginase overexpression in neurons and its effect on traumatic brain injury. Molecular genetics and metabolism. 2018 Academic Article GET IT
Times cited: 18
Designing Dual Transglutaminase 2/Histone Deacetylase Inhibitors Effective at Halting Neuronal Death. ChemMedChem. 2018 Academic Article GET IT
Times cited: 12
Activation of Nrf2 and Hypoxic Adaptive Response Contribute to Neuroprotection Elicited by Phenylhydroxamic Acid Selective HDAC6 Inhibitors. ACS chemical neuroscience. 2018 Academic Article GET IT
Times cited: 25
Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington's Disease Knock-In Mouse Models. Journal of Huntington's disease. 2018 Academic Article GET IT
Times cited: 13
Building on NeuroNEXT: Next generation clinics to cure chronic neurological disability. Annals of neurology. 2017 Editorial Article GET IT
Times cited: 1
Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis. Stroke. 2017 Academic Article GET IT
Times cited: 314
Early recovery of T-cell function predicts improved survival after T-cell depleted allogeneic transplant. Leukemia & lymphoma. 2017 Academic Article GET IT
Times cited: 45
Bioactive Flavonoids and Catechols as Hif1 and Nrf2 Protein Stabilizers - Implications for Parkinson's Disease. Aging and disease. 2016 Academic Article GET IT
Times cited: 19
Hematopoietic Cell Transplantation Comorbidity Index Predicts Outcomes in Patients with Acute Myeloid Leukemia and Myelodysplastic Syndromes Receiving CD34⁺ Selected Grafts for Allogeneic Hematopoietic Cell Transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2016 Academic Article GET IT
Times cited: 19
Oxidative Stress and Huntington's Disease: The Good, The Bad, and The Ugly. Journal of Huntington's disease. 2016 Review GET IT
Times cited: 121
Nature and nurture meet at the epigenome to modulate disorders of the nervous system. Neuroscience letters. 2016 Editorial Article GET IT
Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2016 Academic Article GET IT
Times cited: 130
Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate. eLife. 2016 Academic Article GET IT
Times cited: 393
Inhibition of HIF-prolyl-4-hydroxylases prevents mitochondrial impairment and cell death in a model of neuronal oxytosis. Cell death & disease. 2016 Academic Article GET IT
Times cited: 35
Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models. Science translational medicine. 2016 Academic Article GET IT
Times cited: 100
Butyrate, neuroepigenetics and the gut microbiome: Can a high fiber diet improve brain health?. Neuroscience letters. 2016 Review GET IT
Times cited: 343
Hypoxic Adaptation in the Nervous System: Promise for Novel Therapeutics for Acute and Chronic Neurodegeneration. Advances in experimental medicine and biology. 2016 Review GET IT
Times cited: 10
Daidzein Augments Cholesterol Homeostasis via ApoE to Promote Functional Recovery in Chronic Stroke. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2015 Academic Article GET IT
Times cited: 39
Metabolism and epigenetics in the nervous system: Creating cellular fitness and resistance to neuronal death in neurological conditions via modulation of oxygen-, iron-, and 2-oxoglutarate-dependent dioxygenases. Brain research. 2015 Review GET IT
Times cited: 17
Hydroxamate-based histone deacetylase inhibitors can protect neurons from oxidative stress via a histone deacetylase-independent catalase-like mechanism. Chemistry & biology. 2015 Academic Article GET IT
Times cited: 33
Antihelminthic benzimidazoles are novel HIF activators that prevent oxidative neuronal death via binding to tubulin. Antioxidants & redox signaling. 2015 Academic Article GET IT
Times cited: 15
Recent advances in hydrogen peroxide imaging for biological applications. Cell & bioscience. 2014 Review GET IT
Times cited: 654
Hydroxamic acid-based histone deacetylase (HDAC) inhibitors can mediate neuroprotection independent of HDAC inhibition. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014 Academic Article GET IT
Times cited: 27
cAMP-responsive element-binding protein (CREB) and cAMP co-regulate activator protein 1 (AP1)-dependent regeneration-associated gene expression and neurite growth. The Journal of biological chemistry. 2014 Academic Article GET IT
Times cited: 34
A selective phenelzine analogue inhibitor of histone demethylase LSD1. ACS chemical biology. 2014 Academic Article GET IT
Times cited: 74
The interplay between microRNAs and histone deacetylases in neurological diseases. Neurochemistry international. 2014 Review GET IT
Times cited: 24
Transcriptional dysregulation in Huntington's disease: a failure of adaptive transcriptional homeostasis. Drug discovery today. 2014 Review GET IT
Times cited: 41
An adaptive role for BDNF Val66Met polymorphism in motor recovery in chronic stroke. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014 Academic Article GET IT
Times cited: 80
Spatial, temporal, and quantitative manipulation of intracellular hydrogen peroxide in cultured cells. Methods in enzymology. 2014 Academic Article GET IT
Times cited: 13
Looking above but not beyond the genome for therapeutics in neurology and psychiatry: epigenetic proteins and RNAs find a new focus. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2013 Editorial Article GET IT
Times cited: 2
The epigenetics of stroke recovery and rehabilitation: from polycomb to histone deacetylases. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2013 Review GET IT
Times cited: 13
Two-photon fluorescence imaging of intracellular hydrogen peroxide with chemoselective fluorescent probes. Journal of biomedical optics. 2013 Academic Article GET IT
Times cited: 15
Specific acetylation of p53 by HDAC inhibition prevents DNA damage-induced apoptosis in neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013 Academic Article GET IT
Times cited: 80
Transglutaminase is a therapeutic target for oxidative stress, excitotoxicity and stroke: a new epigenetic kid on the CNS block. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2013 Review GET IT
Times cited: 26
Derivation of multivariate syndromic outcome metrics for consistent testing across multiple models of cervical spinal cord injury in rats. PloS one. 2013 Academic Article GET IT
Times cited: 54
In vitro ischemia suppresses hypoxic induction of hypoxia-inducible factor-1α by inhibition of synthesis and not enhanced degradation. Journal of neuroscience research. 2013 Academic Article GET IT
Times cited: 13
Hypoxia-inducible factor prolyl hydroxylases as targets for neuroprotection by "antioxidant" metal chelators: From ferroptosis to stroke. Free radical biology & medicine. 2013 Review GET IT
Times cited: 92
Epigenetics and the environment: in search of the "toleroasome" vital to execution of ischemic preconditioning. Translational stroke research. 2013 Review GET IT
Times cited: 10
15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) protects neurons from oxidative death via an Nrf2 astrocyte-specific mechanism independent of PPARγ. Journal of neurochemistry. 2013 Academic Article GET IT
Times cited: 32
Advances in Doppler OCT. Chinese optics letters : COL. 2013 Academic Article GET IT
Inhibition of 12/15-lipoxygenase as therapeutic strategy to treat stroke. Annals of neurology. 2012 Academic Article GET IT
Times cited: 87
T cell-depleted stem cell transplantation for adults with high-risk acute lymphoblastic leukemia: long-term survival for patients in first complete remission with a decreased risk of graft-versus-host disease. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2012 Academic Article GET IT
Times cited: 33
A screen for inducers of p21(waf1/cip1) identifies HIF prolyl hydroxylase inhibitors as neuroprotective agents with antitumor properties. Neurobiology of disease. 2012 Academic Article GET IT
Times cited: 28
Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson's disease. Antioxidants & redox signaling. 2012 Academic Article GET IT
Times cited: 129
miR-886-3p levels are elevated in Friedreich ataxia. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 Academic Article GET IT
Times cited: 33
Activating transcription factor 4 mediates hyperglycaemia-induced endothelial inflammation and retinal vascular leakage through activation of STAT3 in a mouse model of type 1 diabetes. Diabetologia. 2012 Academic Article GET IT
Times cited: 105
Transglutaminase inhibition protects against oxidative stress-induced neuronal death downstream of pathological ERK activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 Academic Article GET IT
Times cited: 51
CD36 is involved in astrocyte activation and astroglial scar formation. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2012 Academic Article GET IT
Times cited: 77
Lysophosphatidic acid differentially regulates axonal mRNA translation through 5'UTR elements. Molecular and cellular neurosciences. 2012 Academic Article GET IT
Times cited: 28
Hypoxia-inducible factor prolyl hydroxylase inhibition: robust new target or another big bust for stroke therapeutics?. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2012 Review GET IT
Times cited: 76
Activation of endoplasmic reticulum stress by hyperglycemia is essential for Müller cell-derived inflammatory cytokine production in diabetes. Diabetes. 2012 Academic Article GET IT
Times cited: 138
Improving precision in therapeutics for brain recovery: throwing out the bath water and not the baby. Current opinion in neurology. 2011 Editorial Article GET IT
Histone Deacetylase Inhibitors and Mithramycin A Impact a Similar Neuroprotective Pathway at a Crossroad between Cancer and Neurodegeneration. Pharmaceuticals (Basel, Switzerland). 2011 Academic Article GET IT
Times cited: 20
Development of Neh2-luciferase reporter and its application for high throughput screening and real-time monitoring of Nrf2 activators. Chemistry & biology. 2011 Academic Article GET IT
Times cited: 90
Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 Academic Article GET IT
Times cited: 105
Genetic variant of BDNF (Val66Met) polymorphism attenuates stroke-induced angiogenic responses by enhancing anti-angiogenic mediator CD36 expression. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 Academic Article GET IT
Times cited: 67
Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington's disease mice. Acta neuropathologica. 2010 Academic Article GET IT
Times cited: 118
Controlled enzymatic production of astrocytic hydrogen peroxide protects neurons from oxidative stress via an Nrf2-independent pathway. Proceedings of the National Academy of Sciences of the United States of America. 2010 Academic Article GET IT
Times cited: 119
Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease. EMBO molecular medicine. 2010 Academic Article GET IT
Times cited: 113
Beyond neuroprotection to brain repair: exploring the next frontier in clinical neuroscience to expand the therapeutic window for stroke. Translational stroke research. 2010 Academic Article GET IT
Times cited: 252
Utilization of an in vivo reporter for high throughput identification of branched small molecule regulators of hypoxic adaptation. Chemistry & biology. 2010 Academic Article GET IT
Times cited: 70
HIF prolyl hydroxylase inhibitors prevent neuronal death induced by mitochondrial toxins: therapeutic implications for Huntington's disease and Alzheimer's disease. Antioxidants & redox signaling. 2010 Academic Article GET IT
Times cited: 48
Histone deacetylase inhibitors de-repress tyrosine hydroxylase expression in the olfactory bulb and rostral migratory stream. Biochemical and biophysical research communications. 2010 Academic Article GET IT
Times cited: 10
A large-scale chemical screen for regulators of the arginase 1 promoter identifies the soy isoflavone daidzeinas a clinically approved small molecule that can promote neuronal protection or regeneration via a cAMP-independent pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010 Academic Article GET IT
Times cited: 73
HDAC6 is a target for protection and regeneration following injury in the nervous system. Proceedings of the National Academy of Sciences of the United States of America. 2009 Academic Article GET IT
Times cited: 255
Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases. Biochimica et biophysica acta. 2009 Review GET IT
Times cited: 200
Inhibition of prolyl hydroxylase protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity: model for the potential involvement of the hypoxia-inducible factor pathway in Parkinson disease. The Journal of biological chemistry. 2009 Academic Article GET IT
Times cited: 86
Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009 Academic Article GET IT
Times cited: 101
A nonradioactive dot blot assay for transglutaminase activity. Analytical biochemistry. 2009 Academic Article GET IT
Times cited: 8
Novel multi-modal strategies to promote brain and spinal cord injury recovery. Stroke. 2008 Academic Article GET IT
Times cited: 11
Antioxidants, HIF prolyl hydroxylase inhibitors or short interfering RNAs to BNIP3 or PUMA, can prevent prodeath effects of the transcriptional activator, HIF-1alpha, in a mouse hippocampal neuronal line. Antioxidants & redox signaling. 2008 Academic Article GET IT
Times cited: 42
Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury. Annals of the New York Academy of Sciences. 2008 Academic Article GET IT
Times cited: 47
ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo. The Journal of experimental medicine. 2008 Academic Article GET IT
Times cited: 199
Advances in stroke regenerative medicine 2007. Stroke. 2008 Review GET IT
Times cited: 12
Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 Academic Article GET IT
Times cited: 131
Harnessing hypoxic adaptation to prevent, treat, and repair stroke. Journal of molecular medicine (Berlin, Germany). 2007 Review GET IT
Times cited: 78
CD81, a cell cycle regulator, is a novel target for histone deacetylase inhibition in glioma cells. Neurobiology of disease. 2007 Academic Article GET IT
Times cited: 20
Recent advances in stroke rehabilitation 2006. Stroke. 2007 Review GET IT
Times cited: 32
Role of cyclooxygenase-2 induction by transcription factor Sp1 and Sp3 in neuronal oxidative and DNA damage response. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2006 Academic Article GET IT
Times cited: 57
Arginase 1 regulation of nitric oxide production is key to survival of trophic factor-deprived motor neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006 Academic Article GET IT
Times cited: 48
Oxygen-sensitive reset of hypoxia-inducible factor transactivation response: prolyl hydroxylases tune the biological normoxic set point. Free radical biology & medicine. 2006 Academic Article GET IT
Times cited: 52
The histone deacetylase inhibitor sodium butyrate protects against cisplatin-induced hearing loss in guinea pigs. The Laryngoscope. 2006 Academic Article GET IT
Times cited: 39
Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system. The Journal of biological chemistry. 2005 Academic Article GET IT
Times cited: 269
Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival. The Journal of biological chemistry. 2005 Academic Article GET IT
Times cited: 172
Antioxidants modulate mitochondrial PKA and increase CREB binding to D-loop DNA of the mitochondrial genome in neurons. Proceedings of the National Academy of Sciences of the United States of America. 2005 Academic Article GET IT
Times cited: 136
Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2005 Academic Article GET IT
Times cited: 43
Transglutaminase activity is present in highly purified nonsynaptosomal mouse brain and liver mitochondria. Biochemistry. 2005 Academic Article GET IT
Times cited: 48
Remodeling chromatin and stress resistance in the central nervous system: histone deacetylase inhibitors as novel and broadly effective neuroprotective agents. Current drug targets. CNS and neurological disorders. 2005 Review GET IT
Times cited: 146
Prosurvival and prodeath effects of hypoxia-inducible factor-1alpha stabilization in a murine hippocampal cell line. The Journal of biological chemistry. 2004 Academic Article GET IT
Times cited: 101
Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004 Academic Article GET IT
Times cited: 164
Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease. The Journal of biological chemistry. 2004 Academic Article GET IT
Times cited: 389
Translation of ischemic preconditioning to the patient: prolyl hydroxylase inhibition and hypoxia inducible factor-1 as novel targets for stroke therapy. Stroke. 2004 Review GET IT
Times cited: 75
Novel roles for arginase in cell survival, regeneration, and translation in the central nervous system. The Journal of nutrition. 2004 Review GET IT
Times cited: 56
Oxidative stress-induced death in the nervous system: cell cycle dependent or independent?. Journal of neuroscience research. 2004 Review GET IT
Times cited: 64
The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism. Journal of neurochemistry. 2004 Academic Article GET IT
Times cited: 86
Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway. Proceedings of the National Academy of Sciences of the United States of America. 2003 Academic Article GET IT
Times cited: 857
Therapeutic effects of cystamine in a murine model of Huntington's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2002 Academic Article GET IT
Times cited: 296
Epidermal growth factor receptor induced apoptosis: potentiation by inhibition of Ras signaling. FEBS letters. 2001 Academic Article GET IT
Times cited: 37
The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-kappa B (NF-kappa B)-inducing kinase to activate NF-kappa B. Identification of a novel receptor-tyrosine kinase signalosome. The Journal of biological chemistry. 2000 Academic Article GET IT
Times cited: 115
Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21(waf1/cip1), and erythropoietin. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1999 Academic Article GET IT
Times cited: 306
Long-lasting and rapid calcium changes during mitosis. The Journal of cell biology. 1988 Academic Article GET IT
Times cited: 53
Transition from metaphase to anaphase is accompanied by local changes in cytoplasmic free calcium in Pt K2 kidney epithelial cells. Proceedings of the National Academy of Sciences of the United States of America. 1986 Academic Article GET IT
Times cited: 80
Local cytoplasmic calcium gradients in living mitotic cells. Nature. 1985 Academic Article GET IT
Times cited: 95

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Funding awarded

Clinical and Translational Science Center - UL1 awarded by National Center for Advancing Translational Sciences Co-Investigator 2022 - 2027

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Background

education and training

M.D., Ph.D., New York University School of Medicine 1988
B.A., Amherst College 1981

Contact

full name

Rajiv R. Ratan

primary email

rrr2001@med.cornell.edu

VIVO Weill Cornell Medical College

Rajiv R. Ratan Professor of Neuroscience

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email