selected publications
- Whole Cell Active Inhibitors of Mycobacterial Lipoamide Dehydrogenase Afford Selectivity over the Human Enzyme through Tight Binding Interactions. ACS infectious diseases. 2021 Academic Article GET IT
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Potentiation of rifampin activity in a mouse model of tuberculosis by activation of host transcription factor EB.
PLoS pathogens.
2020
Academic Article
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Times cited: 4 -
Fatal Cytomegalovirus Infection in an Adult with Inherited NOS2 Deficiency.
2020
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Times cited: 29 -
Evidence for dispensability of protein kinase R in host control of tuberculosis.
European journal of immunology.
2018
Academic Article
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Times cited: 8 -
Comparison of transposon and deletion mutants in Mycobacterium tuberculosis: The case of rv1248c, encoding 2-hydroxy-3-oxoadipate synthase.
Tuberculosis (Edinburgh, Scotland).
2015
Academic Article
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Times cited: 4 -
E1 of α-ketoglutarate dehydrogenase defends Mycobacterium tuberculosis against glutamate anaplerosis and nitroxidative stress.
Proceedings of the National Academy of Sciences of the United States of America.
2015
Academic Article
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Times cited: 43 -
Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase.
Biochemistry.
2013
Academic Article
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Times cited: 12 -
Identification of new inhibitors of protein kinase R guided by statistical modeling.
Bioorganic & medicinal chemistry letters.
2011
Academic Article
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Times cited: 18 -
Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier.
Trends in microbiology.
2011
Academic Article
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Times cited: 126 -
Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes.
Cell host & microbe.
2011
Academic Article
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Times cited: 96 -
Triazaspirodimethoxybenzoyls as selective inhibitors of mycobacterial lipoamide dehydrogenase .
Biochemistry.
2010
Academic Article
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Times cited: 22 -
Identification of a copper-binding metallothionein in pathogenic mycobacteria.
Nature chemical biology.
2008
Academic Article
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Times cited: 163 -
A philosophy of anti-infectives as a guide in the search for new drugs for tuberculosis.
Tuberculosis (Edinburgh, Scotland).
2008
Review
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Times cited: 52 -
Selective killing of nonreplicating mycobacteria.
Cell host & microbe.
2008
Academic Article
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Times cited: 151 -
Crystal structure and functional analysis of lipoamide dehydrogenase from Mycobacterium tuberculosis.
The Journal of biological chemistry.
2005
Academic Article
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Times cited: 28 -
Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes.
Molecular microbiology.
2005
Academic Article
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Times cited: 79 -
Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of alpha-ketoglutarate decarboxylase.
Proceedings of the National Academy of Sciences of the United States of America.
2005
Academic Article
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Times cited: 160 -
Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein.
Science (New York, N.Y.).
2002
Academic Article
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Times cited: 329 -
Peroxynitrite reductase activity of bacterial peroxiredoxins.
Nature.
2000
Academic Article
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Times cited: 572 -
Pharmacological modulation of nitric oxide synthesis by mechanism-based inactivators and related inhibitors.
Pharmacology & therapeutics.
1999
Review
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Times cited: 46 -
Studies of neuronal nitric oxide synthase inactivation by diverse suicide inhibitors.
Archives of biochemistry and biophysics.
1999
Academic Article
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Times cited: 13 -
Mechanism of inducible nitric oxide synthase inactivation by aminoguanidine and L-N6-(1-iminoethyl)lysine.
Biochemistry.
1998
Academic Article
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Times cited: 75 -
Pharmacological characterization of guanidinoethyldisulphide (GED), a novel inhibitor of nitric oxide synthase with selectivity towards the inducible isoform.
British journal of pharmacology.
1996
Academic Article
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Times cited: 55