Andersen, Olaf Sparre

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selected publications

Screening for bilayer-active and likely cytotoxic molecules reveals bilayer-mediated regulation of cell function. The Journal of general physiology. 2023 Academic Article GET IT
Capsaicin as an amphipathic modulator of Na_V1.5 mechanosensitivity. Channels (Austin, Tex.). 2022 Academic Article GET IT
Times cited: 3
Regulation of Gramicidin Channel Function Solely by Changes in Lipid Intrinsic Curvature. Frontiers in physiology. 2022 Academic Article GET IT
Times cited: 71
Mechanisms underlying drug-mediated regulation of membrane protein function. Proceedings of the National Academy of Sciences of the United States of America. 2021 Academic Article GET IT
Times cited: 7
Cannabidiol inhibits the skeletal muscle Nav1.4 by blocking its pore and by altering membrane elasticity. The Journal of general physiology. 2021 Academic Article GET IT
Times cited: 24
First-generation physician-scientists are under-represented and need better support. Nature medicine. 2021 Academic Article GET IT
Times cited: 8
Atomistic Characterization of Gramicidin Channel Formation. Journal of chemical theory and computation. 2020 Academic Article GET IT
Times cited: 5
Assessing the Perturbing Effects of Drugs on Lipid Bilayers Using Gramicidin Channel-Based In Silico and In Vitro Assays. Journal of medicinal chemistry. 2020 Academic Article GET IT
Times cited: 8
Synthesis and evaluation of resveratrol derivatives as fetal hemoglobin inducers. Bioorganic chemistry. 2020 Academic Article GET IT
Times cited: 12
How perceptions of a successful physician-scientist varies with gender and academic rank: toward defining physician-scientist's success. BMC medical education. 2020 Academic Article GET IT
Times cited: 8
Quantitative Characterization of Protein-Lipid Interactions by Free Energy Simulation between Binary Bilayers. Journal of chemical theory and computation. 2019 Academic Article GET IT
Times cited: 6
Molecular Mechanism for Gramicidin Dimerization and Dissociation in Bilayers of Different Thickness. Biophysical journal. 2019 Academic Article GET IT
Times cited: 13
Conformational dynamics between transmembrane domains and allosteric modulation of a metabotropic glutamate receptor. eLife. 2019 Academic Article GET IT
Times cited: 31
Antidepressants are modifiers of lipid bilayer properties. The Journal of general physiology. 2019 Academic Article GET IT
Times cited: 27
Gramicidin Increases Lipid Flip-Flop in Symmetric and Asymmetric Lipid Vesicles. Biophysical journal. 2019 Academic Article GET IT
Times cited: 34
Structural basis of Ca²⁺-dependent activation and lipid transport by a TMEM16 scramblase. eLife. 2019 Academic Article GET IT
Times cited: 68
Fluorinated Alcohols' Effects on Lipid Bilayer Properties. Biophysical journal. 2018 Academic Article GET IT
Times cited: 19
Synthetic Analogues of the Snail Toxin 6-Bromo-2-mercaptotryptamine Dimer (BrMT) Reveal That Lipid Bilayer Perturbation Does Not Underlie Its Modulation of Voltage-Gated Potassium Channels. Biochemistry. 2018 Academic Article GET IT
Times cited: 15
In Reply to Sun et al. Academic medicine : journal of the Association of American Medical Colleges. 2018 Comment GET IT
Stopped-Flow Fluorometric Ion Flux Assay for Ligand-Gated Ion Channel Studies. Methods in molecular biology (Clifton, N.J.). 2018 Academic Article GET IT
Times cited: 15
Exchange of Gramicidin between Lipid Bilayers: Implications for the Mechanism of Channel Formation. Biophysical journal. 2017 Academic Article GET IT
Times cited: 12
History and Outcomes of 50 Years of Physician-Scientist Training in Medical Scientist Training Programs. Academic medicine : journal of the Association of American Medical Colleges. 2017 Academic Article GET IT
Times cited: 74
Characterizing Residue-Bilayer Interactions Using Gramicidin A as a Scaffold and Tryptophan Substitutions as Probes. Journal of chemical theory and computation. 2017 Academic Article GET IT
Times cited: 10
Divergent effects of anesthetics on lipid bilayer properties and sodium channel function. European biophysics journal : EBJ. 2017 Review GET IT
Times cited: 14
Timing and Reset Mechanism of GTP Hydrolysis-Driven Conformational Changes of Atlastin. Structure (London, England : 1993). 2017 Academic Article GET IT
Times cited: 19
Introduction to Biophysics Week: What is Biophysics?. Biophysical journal. 2017 Academic Article GET IT
Gateways to the Laboratory: How an MD-PhD Program Increased the Number of Minority Physician-Scientists. Academic medicine : journal of the Association of American Medical Colleges. 2017 Academic Article GET IT
Times cited: 18
Gramicidin A Channel Formation Induces Local Lipid Redistribution I: Experiment and Simulation. Biophysical journal. 2017 Academic Article GET IT
Times cited: 36
Gramicidin A Channel Formation Induces Local Lipid Redistribution II: A 3D Continuum Elastic Model. Biophysical journal. 2017 Academic Article GET IT
Times cited: 18
Clinical concentrations of chemically diverse general anesthetics minimally affect lipid bilayer properties. Proceedings of the National Academy of Sciences of the United States of America. 2017 Academic Article GET IT
Times cited: 38
Effect of Statins on the Nanomechanical Properties of Supported Lipid Bilayers. Biophysical journal. 2016 Academic Article GET IT
Times cited: 29
Introduction to Biophysics Week: What is Biophysics?. Biophysical journal. 2016 Editorial Article GET IT
Times cited: 3
Mind-muscle connection revisited: do 100 studies about beanbag tossing, stick balancing, and dart throwing have any relevance for strength training?. European journal of applied physiology. 2016 Letter GET IT
Times cited: 2
A general mechanism for drug promiscuity: Studies with amiodarone and other antiarrhythmics. The Journal of general physiology. 2015 Academic Article GET IT
Times cited: 31
Bilayer Effects of Antimalarial Compounds. PloS one. 2015 Academic Article GET IT
Times cited: 6
Calcium ions open a selectivity filter gate during activation of the MthK potassium channel. Nature communications. 2015 Academic Article GET IT
Times cited: 29
Perspectives on: The response to osmotic challenges. The Journal of general physiology. 2015 Article GET IT
Times cited: 4
Volatile anesthetics inhibit sodium channels without altering bulk lipid bilayer properties. The Journal of general physiology. 2014 Academic Article GET IT
Times cited: 22
Phytochemicals perturb membranes and promiscuously alter protein function. ACS chemical biology. 2014 Academic Article GET IT
Times cited: 211
Regulation of ion channel function by the host lipid bilayer examined by a stopped-flow spectrofluorometric assay. Biophysical journal. 2014 Academic Article GET IT
Times cited: 25
A KcsA/MloK1 chimeric ion channel has lipid-dependent ligand-binding energetics. The Journal of biological chemistry. 2014 Academic Article GET IT
Times cited: 12
Ion-induced defect permeation of lipid membranes. Biophysical journal. 2014 Academic Article GET IT
Times cited: 81
Membrane proteins: Through thick and thin. Nature chemical biology. 2013 Comment GET IT
Times cited: 5
Whole cell screen for inhibitors of pH homeostasis in Mycobacterium tuberculosis. PloS one. 2013 Academic Article GET IT
Times cited: 55
Small-molecule photostabilizing agents are modifiers of lipid bilayer properties. Biophysical journal. 2013 Academic Article GET IT
Times cited: 39
Phosphoinositides alter lipid bilayer properties. The Journal of general physiology. 2013 Academic Article GET IT
Times cited: 18
HCN1 channels as targets for anesthetic and nonanesthetic propofol analogs in the amelioration of mechanical and thermal hyperalgesia in a mouse model of neuropathic pain. The Journal of pharmacology and experimental therapeutics. 2013 Academic Article GET IT
Times cited: 54
Assessing smectic liquid-crystal continuum models for elastic bilayer deformations. Chemistry and physics of lipids. 2013 Academic Article GET IT
Times cited: 16
Interactions of drugs and amphiphiles with membranes: modulation of lipid bilayer elastic properties by changes in acyl chain unsaturation and protonation. Faraday discussions. 2013 Academic Article GET IT
Times cited: 30
Perspectives on: conformational coupling in ion channels. The Journal of general physiology. 2012 Academic Article GET IT
A designed inhibitor of a CLC antiporter blocks function through a unique binding mode. Chemistry & biology. 2012 Academic Article GET IT
Times cited: 24
Influence of hydrophobic mismatch on structures and dynamics of gramicidin a and lipid bilayers. Biophysical journal. 2012 Academic Article GET IT
Times cited: 82
Quantitative modeling of membrane deformations by multihelical membrane proteins: application to G-protein coupled receptors. Biophysical journal. 2011 Academic Article GET IT
Times cited: 77
Effects of green tea catechins on gramicidin channel function and inferred changes in bilayer properties. FEBS letters. 2011 Academic Article GET IT
Times cited: 18
Alcohol's effects on lipid bilayer properties. Biophysical journal. 2011 Academic Article GET IT
Times cited: 115
Thiazolidinedione insulin sensitizers alter lipid bilayer properties and voltage-dependent sodium channel function: implications for drug discovery. The Journal of general physiology. 2011 Academic Article GET IT
Times cited: 43
Linear rate-equilibrium relations arising from ion channel-bilayer energetic coupling. Proceedings of the National Academy of Sciences of the United States of America. 2011 Academic Article GET IT
Times cited: 25
Gramicidin A backbone and side chain dynamics evaluated by molecular dynamics simulations and nuclear magnetic resonance experiments. I: molecular dynamics simulations. The journal of physical chemistry. B. 2011 Academic Article GET IT
Times cited: 29
Gramicidin A backbone and side chain dynamics evaluated by molecular dynamics simulations and nuclear magnetic resonance experiments. II: nuclear magnetic resonance experiments. The journal of physical chemistry. B. 2011 Academic Article GET IT
Times cited: 5
The membrane interface dictates different anchor roles for "inner pair" and "outer pair" tryptophan indole rings in gramicidin A channels. Biochemistry. 2011 Academic Article GET IT
Times cited: 13
Perspectives on: Ion selectivity. The Journal of general physiology. 2011 Academic Article GET IT
Times cited: 33
The urgent need to increase support for the NIH's MD-PhD student fellowships. Academic medicine : journal of the Association of American Medical Colleges. 2011 Letter GET IT
A one-dimensional continuum elastic model for membrane-embedded gramicidin dimer dissociation. PloS one. 2011 Academic Article GET IT
Times cited: 1
Cells on the MEND: exploring the role of lipidic forces in membrane trafficking. The Journal of general physiology. 2011 Comment GET IT
Times cited: 1
Energetics of double-ion occupancy in the gramicidin A channel. The journal of physical chemistry. B. 2010 Academic Article GET IT
Times cited: 13
Gramicidin-based fluorescence assay; for determining small molecules potential for modifying lipid bilayer properties. Journal of visualized experiments : JoVE. 2010 Academic Article GET IT
Times cited: 23
Medical Scientist Training Programs: federal funding offers support and drives innovation. Academic medicine : journal of the Association of American Medical Colleges. 2010 Comment GET IT
Times cited: 2
Cholesterol modulates the membrane effects and spatial organization of membrane-penetrating ligands for G-protein coupled receptors. The journal of physical chemistry. B. 2010 Academic Article GET IT
Times cited: 26
Polar groups in membrane channels: consequences of replacing alanines with serines in membrane-spanning gramicidin channels. Biochemistry. 2010 Academic Article GET IT
Times cited: 6
Amphiphile regulation of ion channel function by changes in the bilayer spring constant. Proceedings of the National Academy of Sciences of the United States of America. 2010 Academic Article GET IT
Times cited: 99
A combined experimental and theoretical study of ion solvation in liquid N-methylacetamide. Journal of the American Chemical Society. 2010 Academic Article GET IT
Times cited: 33
Screening for small molecules' bilayer-modifying potential using a gramicidin-based fluorescence assay. Assay and drug development technologies. 2010 Academic Article GET IT
Times cited: 52
Are MD-PhD programs meeting their goals? An analysis of career choices made by graduates of 24 MD-PhD programs. Academic medicine : journal of the Association of American Medical Colleges. 2010 Academic Article GET IT
Lipid bilayer regulation of membrane protein function: gramicidin channels as molecular force probes. Journal of the Royal Society, Interface. 2009 Review GET IT
Times cited: 65
The two-membrane model of epithelial transport: Koefoed-Johnsen and Ussing (1958). The Journal of general physiology. 2008 Academic Article GET IT
Times cited: 14
Single molecule methods for monitoring changes in bilayer elastic properties. Journal of visualized experiments : JoVE. 2008 Academic Article GET IT
Times cited: 3
Preparation of artificial bilayers for electrophysiology experiments. Journal of visualized experiments : JoVE. 2008 Academic Article GET IT
Times cited: 7
The antimicrobial peptide gramicidin S permeabilizes phospholipid bilayer membranes without forming discrete ion channels. Biochimica et biophysica acta. 2008 Academic Article GET IT
Times cited: 51
Comment on "Free energy simulations of single and double ion occupancy in gramicidin A" [J. Chem. Phys. 126, 105103 (2007)]. The Journal of chemical physics. 2008 Letter GET IT
Times cited: 18
The preference of tryptophan for membrane interfaces: insights from N-methylation of tryptophans in gramicidin channels. The Journal of biological chemistry. 2008 Academic Article GET IT
Times cited: 84
Models and mechanistic insight. The Journal of general physiology. 2008 Editorial Article GET IT
Times cited: 6
Perspectives on how to drug an ion channel. The Journal of general physiology. 2008 Article GET IT
Times cited: 23
Curcumin is a modulator of bilayer material properties. Biochemistry. 2007 Academic Article GET IT
Times cited: 122
The inhibitory effect of (-)-epigallocatechin gallate on activation of the epidermal growth factor receptor is associated with altered lipid order in HT29 colon cancer cells. Cancer research. 2007 Academic Article GET IT
Times cited: 183
Docosahexaenoic acid alters bilayer elastic properties. Proceedings of the National Academy of Sciences of the United States of America. 2007 Academic Article GET IT
Times cited: 114
Bilayer thickness and membrane protein function: an energetic perspective. Annual review of biophysics and biomolecular structure. 2007 Review GET IT
Times cited: 639
Single-molecule methods for monitoring changes in bilayer elastic properties. Methods in molecular biology (Clifton, N.J.). 2007 Review GET IT
Times cited: 32
Effects of glycine substitutions on the structure and function of gramicidin a channels. Biochemistry. 2006 Academic Article GET IT
Times cited: 4
2,3-butanedione monoxime affects cystic fibrosis transmembrane conductance regulator channel function through phosphorylation-dependent and phosphorylation-independent mechanisms: the role of bilayer material properties. Molecular pharmacology. 2006 Academic Article GET IT
Times cited: 23
Molecular dynamics - potential of mean force calculations as a tool for understanding ion permeation and selectivity in narrow channels. Biophysical chemistry. 2006 Academic Article GET IT
Times cited: 163
Ion permeation through a narrow channel: using gramicidin to ascertain all-atom molecular dynamics potential of mean force methodology and biomolecular force fields. Biophysical journal. 2006 Academic Article GET IT
Times cited: 123
Capsaicin regulates voltage-dependent sodium channels by altering lipid bilayer elasticity. Molecular pharmacology. 2005 Academic Article GET IT
Times cited: 177
Gramicidin channels. IEEE transactions on nanobioscience. 2005 Review GET IT
Times cited: 116
The 58th annual meeting and symposium of the society of general physiologists: lipid signaling in physiology. The Journal of general physiology. 2005 Conference Paper GET IT
Times cited: 1
A brief history of the journal of general physiology. The Journal of general physiology. 2005 Academic Article GET IT
Times cited: 16
Editorial. The Journal of general physiology. 2005 Editorial Article GET IT
On the importance of atomic fluctuations, protein flexibility, and solvent in ion permeation. The Journal of general physiology. 2004 Academic Article GET IT
Times cited: 127
Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers. Nature. 2004 Academic Article GET IT
Times cited: 246
Voltage-gated ion channels in nociceptors: modulation by cGMP. Journal of neurophysiology. 2004 Academic Article GET IT
Times cited: 24
Regulation of sodium channel function by bilayer elasticity: the importance of hydrophobic coupling. Effects of Micelle-forming amphiphiles and cholesterol. The Journal of general physiology. 2004 Academic Article GET IT
Times cited: 213
The 57th Annual Meeting and Symposium of the Society of General Physiologists: the biology of chloride. The Journal of general physiology. 2004 Conference Paper GET IT
Energetics of ion conduction through the gramicidin channel. Proceedings of the National Academy of Sciences of the United States of America. 2003 Academic Article GET IT
Times cited: 335
Genistein can modulate channel function by a phosphorylation-independent mechanism: importance of hydrophobic mismatch and bilayer mechanics. Biochemistry. 2003 Academic Article GET IT
Times cited: 126
Structure of gramicidin a in a lipid bilayer environment determined using molecular dynamics simulations and solid-state NMR data. Journal of the American Chemical Society. 2003 Academic Article GET IT
Times cited: 121
Hydrophobic coupling of lipid bilayer energetics to channel function. The Journal of general physiology. 2003 Academic Article GET IT
Times cited: 80
Cholesterol-induced protein sorting: an analysis of energetic feasibility. Biophysical journal. 2003 Academic Article GET IT
Times cited: 109
The structure, cation binding, transport, and conductance of Gly15-gramicidin A incorporated into SDS micelles and PC/PG vesicles. Biochemistry. 2003 Academic Article GET IT
Times cited: 23
The 56th Annual Meeting and Symposium of the Society of General Physiologists: trafficking of transporters. The Journal of general physiology. 2003 Conference Paper GET IT
Conformational control through translocational regulation: a new view of secretory and membrane protein folding. BioEssays : news and reviews in molecular, cellular and developmental biology. 2002 Review GET IT
Times cited: 12
The 55th Annual Meeting and Symposium of the Society of General Physiologists: molecular motors. The Journal of general physiology. 2002 Conference Paper GET IT
The 54th Annual Meeting and Symposium of the Society of General Physiologists: structures and mechanisms of channels and transport proteins. The Journal of general physiology. 2001 Conference Paper GET IT
Peptide backbone chemistry and membrane channel function: effects of a single amide-to-ester replacement on gramicidin channel structure and function. Biochemistry. 2001 Academic Article GET IT
Times cited: 10
Inclusion-induced bilayer deformations: effects of monolayer equilibrium curvature. Biophysical journal. 2000 Academic Article GET IT
Times cited: 133
Neighboring aliphatic/aromatic side chain interactions between residues 9 and 10 in gramicidin channels. Biochemistry. 2000 Academic Article GET IT
Times cited: 12
Membranes, sensors and cell surfaces. Molecular membrane biology. 2000 Conference Paper GET IT
Sequencing and the single channel. Biophysical journal. 1999 Review GET IT
Times cited: 11
Graphic representation of the results of kinetic analyses. The Journal of general physiology. 1999 Editorial Article GET IT
Times cited: 24
Gramicidin channel controversy--the structure in a lipid environment. Nature structural biology. 1999 Academic Article GET IT
Times cited: 83
Perspectives on ion permeation. The Journal of general physiology. 1999 Academic Article GET IT
Times cited: 9
Perspectives on ion channel assembly. The Journal of general physiology. 1999 Academic Article GET IT
Times cited: 1
Spring constants for channel-induced lipid bilayer deformations. Estimates using gramicidin channels. Biophysical journal. 1999 Academic Article GET IT
Times cited: 156
The 52nd annual meeting and symposium of the Society of General Physiologists. Local calcium signaling in cell physiology. The Journal of general physiology. 1999 Conference Paper GET IT
Times cited: 2
Modulation of gramicidin channel structure and function by the aliphatic "spacer" residues 10, 12, and 14 between the tryptophans. Biochemistry. 1999 Academic Article GET IT
Times cited: 16
Design and characterization of gramicidin channels with side chain or backbone mutations. Novartis Foundation symposium. 1999 Review GET IT
Times cited: 10
Design and characterization of gramicidin channels. Methods in enzymology. 1999 Academic Article GET IT
Times cited: 64
Editorial. The Journal of general physiology. 1999 Academic Article GET IT
Ion channels as tools to monitor lipid bilayer-membrane protein interactions: gramicidin channels as molecular force transducers. Methods in enzymology. 1999 Academic Article GET IT
Times cited: 87
Editorial: perspectives in general physiology. The Journal of general physiology. 1998 Academic Article GET IT
Energetics of inclusion-induced bilayer deformations. Biophysical journal. 1998 Academic Article GET IT
Times cited: 292
The 51st annual meeting and symposium of the society of general physiologists. Mechanisms Of secretion. The Journal of general physiology. 1998 Academic Article GET IT
Editorial. The Journal of general physiology. 1998 Academic Article GET IT
Gramicidin channel kinetics under tension. Biophysical journal. 1998 Academic Article GET IT
Times cited: 109
Gramicidin channels in phospholipid bilayers with unsaturated acyl chains. Biophysical journal. 1997 Academic Article GET IT
Times cited: 42
The conformational preference of gramicidin channels is a function of lipid bilayer thickness. FEBS letters. 1997 Academic Article GET IT
Times cited: 112
Lipid bilayer electrostatic energy, curvature stress, and assembly of gramicidin channels. Biochemistry. 1997 Academic Article GET IT
Times cited: 125
The 50th Annual Meeting and Symposium of the Society of General Physiologists. Cytoskeletal regulation of membrane function. The Journal of general physiology. 1997 Conference Paper GET IT
The Journal of General Physiology. The Journal of general physiology. 1997 Editorial Article GET IT
Gramicidin channels--a solvable membrane "protein" folding problem. Indian journal of biochemistry & biophysics. 1996 Review GET IT
Times cited: 19
Membrane stiffness and channel function. Biochemistry. 1996 Academic Article GET IT
Times cited: 254
Engineering the gramicidin channel. Annual review of biophysics and biomolecular structure. 1996 Review GET IT
Times cited: 219
Gramicidin channel function does not depend on phospholipid chirality. Biochemistry. 1995 Academic Article GET IT
Times cited: 37
Stabilizing effect of D-alanine2 in gramicidin channels. Biochemistry. 1995 Academic Article GET IT
Times cited: 30
Voltage-dependent gating of an asymmetric gramicidin channel. Proceedings of the National Academy of Sciences of the United States of America. 1995 Academic Article GET IT
Times cited: 35
Lysophospholipids modulate channel function by altering the mechanical properties of lipid bilayers. The Journal of general physiology. 1994 Academic Article GET IT
Times cited: 247
Asymmetric gramicidin channels: heterodimeric channels with a single F6Val1 residue. Biophysical journal. 1994 Academic Article GET IT
Times cited: 26
Helix sense of gramicidin channels as a "nonlocal" function of the primary sequence. The Journal of biological chemistry. 1994 Academic Article GET IT
Times cited: 12
Closed state of gramicidin channel detected by X-ray in-plane scattering. Biophysical chemistry. 1994 Academic Article GET IT
Times cited: 30
Energetics of heterodimer formation among gramicidin analogues with an NH2-terminal addition or deletion. Consequences of missing a residue at the join in the channel. Journal of molecular biology. 1993 Academic Article GET IT
Times cited: 49
Proton block of rat brain sodium channels. Evidence for two proton binding sites and multiple occupancy. The Journal of general physiology. 1993 Academic Article GET IT
Times cited: 43
Molecular determinants of channel function. Physiological reviews. 1992 Review GET IT
Times cited: 191
Influence of acylation on the channel characteristics of gramicidin A. Biochemistry. 1992 Academic Article GET IT
Times cited: 15
Molecular and channel-forming characteristics of gramicidin K's: a family of naturally occurring acylated gramicidins. Biochemistry. 1992 Academic Article GET IT
Times cited: 12
Gramicidin channels that have no tryptophan residues. Biochemistry. 1992 Academic Article GET IT
Times cited: 77
Carbodiimide modification reduces the conductance and increases the tetrodotoxin sensitivity in batrachotoxin-modified sodium channels. Pflugers Archiv : European journal of physiology. 1992 Academic Article GET IT
Times cited: 2
A dipolar amino acid substitution induces voltage-dependent transitions between two stable conductance states in gramicidin channels. Biophysical journal. 1992 Academic Article GET IT
Times cited: 7
Amino acid substitutions and ion channel function. Model-dependent conclusions. Biophysical journal. 1992 Academic Article GET IT
Times cited: 40
Formation of non-beta 6.3-helical gramicidin channels between sequence-substituted gramicidin analogues. Biophysical journal. 1992 Academic Article GET IT
Times cited: 48
Models for gramicidin channels. Biophysical journal. 1992 Letter GET IT
Times cited: 1
Dimer versus tetramer. Biophysical journal. 1992 Letter GET IT
Times cited: 2
On the helix sense of gramicidin A single channels. Proteins. 1992 Academic Article GET IT
Times cited: 54
On the supramolecular organization of gramicidin channels. The elementary conducting unit is a dimer. Biophysical journal. 1992 Academic Article GET IT
Times cited: 40
Amino acid sequence modulation of gramicidin channel function: effects of tryptophan-to-phenylalanine substitutions on the single-channel conductance and duration. Biochemistry. 1991 Academic Article GET IT
Times cited: 136
Steady-state gating of batrachotoxin-modified sodium channels. Variability and electrolyte-dependent modulation. The Journal of general physiology. 1991 Academic Article GET IT
Times cited: 17
Surface charges and ion channel function. Annual review of physiology. 1991 Review GET IT
Times cited: 206
Kinetics of gramicidin channel formation in lipid bilayers: transmembrane monomer association. Science (New York, N.Y.). 1990 Academic Article GET IT
Times cited: 216
Gramicidins A, B, and C form structurally equivalent ion channels. Biophysical journal. 1990 Academic Article GET IT
Times cited: 35
Gramicidin single-channel properties show no solvent-history dependence. Biophysical journal. 1990 Academic Article GET IT
Times cited: 34
Distinction between dipolar and inductive effects in modulating the conductance of gramicidin channels. Biochemistry. 1990 Academic Article GET IT
Times cited: 44
Energetics of gramicidin hybrid channel formation as a test for structural equivalence. Side-chain substitutions in the native sequence. Journal of molecular biology. 1990 Academic Article GET IT
Times cited: 61
Platelet-activating factor is a general membrane perturbant. Biochimica et biophysica acta. 1989 Academic Article GET IT
Times cited: 74
Induction of conductance heterogeneity in gramicidin channels. Biochemistry. 1989 Academic Article GET IT
Times cited: 76
Functional carboxyl groups in the red cell anion exchange protein. Modification with an impermeant carbodiimide. The Journal of general physiology. 1989 Academic Article GET IT
Times cited: 14
Interactions of amiloride and small monovalent cations with the epithelial sodium channel. Inferences about the nature of the channel pore. Biophysical journal. 1989 Academic Article GET IT
Times cited: 26
Elementary aspects of acid-base permeation and pH regulation. Annals of the New York Academy of Sciences. 1989 Review GET IT
Times cited: 10
Kinetics of ion movement mediated by carriers and channels. Methods in enzymology. 1989 Academic Article GET IT
Times cited: 45
Batrachotoxin-modified sodium channels in planar lipid bilayers. Characterization of saxitoxin- and tetrodotoxin-induced channel closures. The Journal of general physiology. 1987 Academic Article GET IT
Times cited: 60
Batrachotoxin-modified sodium channels in planar lipid bilayers. Ion permeation and block. The Journal of general physiology. 1987 Academic Article GET IT
Times cited: 99
On the conductance heterogeneity in membrane channels formed by gramicidin A. A cooperative study. Biophysical journal. 1987 Academic Article GET IT
Times cited: 23
Single-channel studies on linear gramicidins with altered amino acid side chains. Effects of altering the polarity of the side chain at position 1 in gramicidin A. Biophysical journal. 1986 Academic Article GET IT
Times cited: 68
Structural information from functional measurements: single-channel studies on gramicidin analogues. Biophysical journal. 1986 Academic Article GET IT
Times cited: 15
Surface charges near the guanidinium neurotoxin binding site. Annals of the New York Academy of Sciences. 1986 Academic Article GET IT
Times cited: 9
Intrinsic characteristics of the proton pump in the luminal membrane of a tight urinary epithelium. The relation between transport rate and delta mu H. The Journal of general physiology. 1985 Academic Article GET IT
Times cited: 42
Primary defects of the hand with intrinsic paralysis. Leprosy review. 1984 Academic Article GET IT
Times cited: 1
Autoimmune haemolytic anaemia treated with multiple transfusions, immunosuppressive therapy, plasma exchange, and desferrioxamine. 1984 GET IT
Times cited: 15
Gramicidin channels. Annual review of physiology. 1984 Review GET IT
Times cited: 239
Single-channel studies on linear gramicidins with altered amino acid sequences. A comparison of phenylalanine, tryptophane, and tyrosine substitutions at positions 1 and 11. Biophysical journal. 1984 Academic Article GET IT
Times cited: 64
Ion movement through gramicidin A channels. Interfacial polarization effects on single-channel current measurements. Biophysical journal. 1983 Academic Article GET IT
Times cited: 48
Ion movement through gramicidin A channels. Single-channel measurements at very high potentials. Biophysical journal. 1983 Academic Article GET IT
Times cited: 192
Ion movement through gramicidin A channels. Studies on the diffusion-controlled association step. Biophysical journal. 1983 Academic Article GET IT
Times cited: 104
Chloride--bicarbonate exchange in red blood cells: physiology of transport and chemical modification of binding sites. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 1982 Academic Article GET IT
Times cited: 93
Monazomycin-induced single channels. I. Characterization of the elementary conductance events. The Journal of general physiology. 1982 Academic Article GET IT
Times cited: 19
Monazomycin-induced single channels. II. Origin of the voltage dependence of the macroscopic conductance. The Journal of general physiology. 1982 Academic Article GET IT
Times cited: 10
Electrogenic proton transport in epithelial membranes. The Journal of membrane biology. 1982 Review GET IT
Times cited: 50
The anion transport protein of the red cell membrane. A zipper mechanism of anion exchange. The Tokai journal of experimental and clinical medicine. 1982 Academic Article GET IT
Times cited: 21
The gramicidin A channel: a review of its permeability characteristics with special reference to the single-file aspect of transport. The Journal of membrane biology. 1981 Academic Article GET IT
Times cited: 260
Ion movement through gramicidin A channels. On the importance of the aqueous diffusion resistance and ion-water interactions. Acta physiologica Scandinavica. Supplementum. 1980 Academic Article GET IT
Times cited: 53
On the adsorption of phloretin onto a black lipid membrane. Biophysical journal. 1979 Academic Article GET IT
Times cited: 37
Electrostatic interactions among hydrophobic ions in lipid bilayer membranes. Biophysical journal. 1978 Academic Article GET IT
Times cited: 124
Receptor binding and biological effect of insulin in human adipocytes. Diabetologia. 1977 Academic Article GET IT
Times cited: 15
Effect of phloretin on the permeability of thin lipid membranes. The Journal of general physiology. 1976 Academic Article GET IT
Times cited: 244
Potential energy barriers to ion transport within lipid bilayers. Studies with tetraphenylborate. Biophysical journal. 1975 Academic Article GET IT
Times cited: 167
Oxygen-linked hydrogen ion binding of human hemoglobin. Effects of carbon dioxide and 2,3-diphosphoglycerate. IV. Thermodynamical relationship between the variables. Scandinavian journal of clinical and laboratory investigation. 1972 Academic Article GET IT
Times cited: 18
The synthesis and estimation of N-C14-methyl labeled levorphanol and its biological disposition in the monkey, dog and rat. The Journal of pharmacology and experimental therapeutics. 1958 Academic Article GET IT
Times cited: 2

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Research

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Co-investigator Network

Funding awarded

Clinical and Translational Science Center - TL1 awarded by National Center for Advancing Translational Sciences Principal Investigator 2022 - 2027
Energetics of Channel-Bilayer Interactions awarded by National Institute of General Medical Sciences Principal Investigator 2018 - 2024

Clinical and Translational Science Center - UL1 awarded by National Center for Advancing Translational Sciences Key Personnel 2022 - 2027
Weill Cornell/Rockefeller/Sloan Kettering MST Program awarded by National Institute of General Medical Sciences Key Personnel 2019 - 2024

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Background

education and training

M.D., Copenhagen University Faculty of Medicine (Denmark) 1971

Contact

full name

Olaf Sparre Andersen

primary email

sparre@med.cornell.edu

VIVO Weill Cornell Medical College

Olaf Sparre Andersen Professor of Physiology and Biophysics

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email