Karuppagounder, Saravanan

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The drug adaptaquin blocks ATF4/CHOP-dependent pro-death Trib3 induction and protects in cellular and mouse models of Parkinson's disease. Neurobiology of disease. 2020 Academic Article GET IT
Times cited: 32
Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke. Cell. 2019 Academic Article GET IT
Times cited: 445
Ferroptosis in Neurons and Cancer Cells Is Similar But Differentially Regulated by Histone Deacetylase Inhibitors. eNeuro. 2019 Academic Article GET IT
Times cited: 48
Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis. Stroke. 2017 Academic Article GET IT
Times cited: 314
Bioactive Flavonoids and Catechols as Hif1 and Nrf2 Protein Stabilizers - Implications for Parkinson's Disease. Aging and disease. 2016 Academic Article GET IT
Times cited: 19
Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate. eLife. 2016 Academic Article GET IT
Times cited: 393
Inhibition of HIF-prolyl-4-hydroxylases prevents mitochondrial impairment and cell death in a model of neuronal oxytosis. Cell death & disease. 2016 Academic Article GET IT
Times cited: 35
Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models. Science translational medicine. 2016 Academic Article GET IT
Times cited: 100
Metabolism and epigenetics in the nervous system: Creating cellular fitness and resistance to neuronal death in neurological conditions via modulation of oxygen-, iron-, and 2-oxoglutarate-dependent dioxygenases. Brain research. 2015 Review GET IT
Times cited: 17
Antihelminthic benzimidazoles are novel HIF activators that prevent oxidative neuronal death via binding to tubulin. Antioxidants & redox signaling. 2015 Academic Article GET IT
Times cited: 15
Hydroxamic acid-based histone deacetylase (HDAC) inhibitors can mediate neuroprotection independent of HDAC inhibition. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014 Academic Article GET IT
Times cited: 27
The epigenetics of stroke recovery and rehabilitation: from polycomb to histone deacetylases. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2013 Review GET IT
Times cited: 13
Sodium salicylate protects against rotenone-induced parkinsonism in rats. Synapse (New York, N.Y.). 2013 Academic Article GET IT
Times cited: 24
In vitro ischemia suppresses hypoxic induction of hypoxia-inducible factor-1α by inhibition of synthesis and not enhanced degradation. Journal of neuroscience research. 2013 Academic Article GET IT
Times cited: 13
Hypoxia-inducible factor prolyl hydroxylases as targets for neuroprotection by "antioxidant" metal chelators: From ferroptosis to stroke. Free radical biology & medicine. 2013 Review GET IT
Times cited: 92
Quercetin up-regulates mitochondrial complex-I activity to protect against programmed cell death in rotenone model of Parkinson's disease in rats. Neuroscience. 2013 Academic Article GET IT
Times cited: 162
Hypoxia-inducible factor prolyl hydroxylase inhibition: robust new target or another big bust for stroke therapeutics?. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2012 Review GET IT
Times cited: 76
Histone Deacetylase Inhibitors and Mithramycin A Impact a Similar Neuroprotective Pathway at a Crossroad between Cancer and Neurodegeneration. Pharmaceuticals (Basel, Switzerland). 2011 Academic Article GET IT
Times cited: 20
Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease. Neurochemistry international. 2008 Academic Article GET IT
Times cited: 405
Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model. Neurobiology of aging. 2008 Academic Article GET IT
Times cited: 107
Translocation of amyloid precursor protein C-terminal fragment(s) to the nucleus precedes neuronal death due to thiamine deficiency-induced mild impairment of oxidative metabolism. Neurochemical research. 2008 Academic Article GET IT
Times cited: 16
Responses of the mitochondrial alpha-ketoglutarate dehydrogenase complex to thiamine deficiency may contribute to regional selective vulnerability. Neurochemistry international. 2007 Academic Article GET IT
Times cited: 37
Changes in inflammatory processes associated with selective vulnerability following mild impairment of oxidative metabolism. Neurobiology of disease. 2007 Academic Article GET IT
Times cited: 50
CD40L deletion delays neuronal death in a model of neurodegeneration due to mild impairment of oxidative metabolism. Journal of neuroimmunology. 2005 Academic Article GET IT
Times cited: 14

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Background

education and training

Ph.D., University of Calcutta (India) 2004
M.S., Jadavpur Universiity (India) 2000
B.S., Madras Medical College, University of Madras (India) 1995

Contact

full name

Saravanan Karuppagounder

primary email

ssk2004@med.cornell.edu

VIVO Weill Cornell Medical College

Saravanan Karuppagounder Assistant Professor of Research in Neuroscience

Publications

selected publications

Background

education and training

Contact

full name

primary email