Vallabhajosula, Shankar

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selected publications

Phase I trial of docetaxel plus lutetium-177-labeled anti-prostate-specific membrane antigen monoclonal antibody J591 (¹⁷⁷Lu-J591) for metastatic castration-resistant prostate cancer. Urologic oncology. 2020 Academic Article GET IT
Times cited: 20
Pilot Study of Hyperfractionated Dosing of Lutetium-177-Labeled Antiprostate-Specific Membrane Antigen Monoclonal Antibody J591 (¹⁷⁷ Lu-J591) for Metastatic Castration-Resistant Prostate Cancer. The oncologist. 2020 Academic Article GET IT
Times cited: 24
Phase 1/2 study of fractionated dose lutetium-177-labeled anti-prostate-specific membrane antigen monoclonal antibody J591 (¹⁷⁷ Lu-J591) for metastatic castration-resistant prostate cancer. Cancer. 2019 Academic Article GET IT
Times cited: 73
Increased Alzheimer's risk during the menopause transition: A 3-year longitudinal brain imaging study. PloS one. 2018 Academic Article GET IT
Times cited: 81
Associations of lifestyle and vascular risk factors with Alzheimer's brain biomarker changes during middle age: a 3-year longitudinal study in the broader New York City area. BMJ open. 2018 Academic Article GET IT
Times cited: 23
Prostaglandin D2/J2 signaling pathway in a rat model of neuroinflammation displaying progressive parkinsonian-like pathology: potential novel therapeutic targets. Journal of neuroinflammation. 2018 Academic Article GET IT
Times cited: 14
18F-FPEB PET/CT Shows mGluR5 Upregulation in Parkinson's Disease. Journal of neuroimaging : official journal of the American Society of Neuroimaging. 2018 Academic Article GET IT
Times cited: 21
Noninvasive PK11195-PET Image Analysis Techniques Can Detect Abnormal Cerebral Microglial Activation in Parkinson's Disease. Journal of neuroimaging : official journal of the American Society of Neuroimaging. 2018 Academic Article GET IT
Times cited: 22
Mediterranean diet and 3-year Alzheimer brain biomarker changes in middle-aged adults. Neurology. 2018 Academic Article GET IT
Times cited: 103
Correction: Perimenopause and emergence of an Alzheimer's bioenergetic phenotype in brain and periphery. PloS one. 2018 Academic Article GET IT
Times cited: 10
Odor Identification Ability Predicts PET Amyloid Status and Memory Decline in Older Adults. Journal of Alzheimer's disease : JAD. 2018 Academic Article GET IT
Times cited: 22
[¹¹ C]arachidonic acid incorporation measurement in human brain: Optimization for clinical use. Synapse (New York, N.Y.). 2017 Academic Article GET IT
Times cited: 7
Perimenopause and emergence of an Alzheimer's bioenergetic phenotype in brain and periphery. PloS one. 2017 Academic Article GET IT
Times cited: 80
Assessment of PSMA targeting ligands bearing novel chelates with application to theranostics: Stability and complexation kinetics of ⁶⁸Ga³⁺, ¹¹¹In³⁺, ¹⁷⁷Lu³⁺ and ²²⁵Ac³. Nuclear medicine and biology. 2017 Academic Article GET IT
Times cited: 19
Sex differences in Alzheimer risk: Brain imaging of endocrine vs chronologic aging. Neurology. 2017 Academic Article GET IT
Times cited: 129
Continuation of comprehensive quality control of the itG ⁶⁸Ge/⁶⁸Ga generator and production of ⁶⁸Ga-DOTATOC and ⁶⁸Ga-PSMA-HBED-CC for clinical research studies. Nuclear medicine and biology. 2017 Academic Article GET IT
Times cited: 6
Reduction of PK11195 uptake observed in multiple sclerosis lesions after natalizumab initiation. Multiple sclerosis and related disorders. 2017 Academic Article GET IT
Times cited: 23
Relationships among Cortical Glutathione Levels, Brain Amyloidosis, and Memory in Healthy Older Adults Investigated In Vivo with ¹H-MRS and Pittsburgh Compound-B PET. AJNR. American journal of neuroradiology. 2017 Academic Article GET IT
Times cited: 42
Radioiodinated Capsids Facilitate In Vivo Non-Invasive Tracking of Adeno-Associated Gene Transfer Vectors. Scientific reports. 2017 Academic Article GET IT
Times cited: 13
Cognitive deficits in non-demented diabetic elderly appear independent of brain amyloidosis. Journal of the neurological sciences. 2016 Academic Article GET IT
Times cited: 3
Transient and chronic seizure-induced inflammation in human focal epilepsy. 2016 GET IT
Times cited: 42
Comprehensive Quality Control of the ITG 68Ge/68Ga Generator and Synthesis of 68Ga-DOTATOC and 68Ga-PSMA-HBED-CC for Clinical Imaging. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2016 Academic Article GET IT
Times cited: 35
Radioimmunotherapy of Metastatic Prostate Cancer with ¹⁷⁷Lu-DOTAhuJ591 Anti Prostate Specific Membrane Antigen Specific Monoclonal Antibody. Current radiopharmaceuticals. 2016 Review GET IT
Times cited: 54
Striatal dopamine type 2 receptor availability in anorexia nervosa. Psychiatry research. 2015 Academic Article GET IT
Times cited: 28
Nutrient patterns and brain biomarkers of Alzheimer's disease in cognitively normal individuals. The journal of nutrition, health & aging. 2015 Academic Article GET IT
Times cited: 108
Cortical laminar binding of PET amyloid and tau tracers in Alzheimer disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2015 Academic Article GET IT
Times cited: 19
Periodontal disease associates with higher brain amyloid load in normal elderly. Neurobiology of aging. 2014 Academic Article GET IT
Times cited: 164
99mTc-labeled small-molecule inhibitors of prostate-specific membrane antigen: pharmacokinetics and biodistribution studies in healthy subjects and patients with metastatic prostate cancer. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2014 Academic Article GET IT
Times cited: 109
Physical Activity, Mediterranean Diet and Biomarkers-Assessed Risk of Alzheimer's: A Multi-Modality Brain Imaging Study. Advances in molecular imaging. 2014 Academic Article GET IT
Times cited: 30
Reduced glucose uptake and Aβ in brain regions with hyperintensities in connected white matter. NeuroImage. 2014 Academic Article GET IT
Times cited: 21
Nutrient intake and brain biomarkers of Alzheimer's disease in at-risk cognitively normal individuals: a cross-sectional neuroimaging pilot study. BMJ open. 2014 Academic Article GET IT
Times cited: 64
PACAP27 prevents Parkinson-like neuronal loss and motor deficits but not microglia activation induced by prostaglandin J2. Biochimica et biophysica acta. 2014 Academic Article GET IT
Times cited: 35
FDG and Amyloid PET in Cognitively Normal Individuals at Risk for Late-Onset Alzheimer's Disease. Advances in molecular imaging. 2014 Academic Article GET IT
Times cited: 82
Brain imaging of cognitively normal individuals with 2 parents affected by late-onset AD. Neurology. 2014 Academic Article GET IT
Times cited: 45
Bone marrow recovery and subsequent chemotherapy following radiolabeled anti-prostate-specific membrane antigen monoclonal antibody j591 in men with metastatic castration-resistant prostate cancer. Frontiers in oncology. 2013 Academic Article GET IT
Times cited: 21
Phase II study of Lutetium-177-labeled anti-prostate-specific membrane antigen monoclonal antibody J591 for metastatic castration-resistant prostate cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2013 Academic Article GET IT
Times cited: 321
First-in-man evaluation of 2 high-affinity PSMA-avid small molecules for imaging prostate cancer. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2013 Academic Article GET IT
Times cited: 171
Early assessment of radiation response using a novel functional imaging modality -- [18F]fluorocholine PET (FCH-PET): a pilot study. Discovery medicine. 2012 Academic Article GET IT
Times cited: 14
Prostate-specific membrane antigen-based imaging. Urologic oncology. 2012 Review GET IT
Times cited: 84
Amyloid and metabolic positron emission tomography imaging of cognitively normal adults with Alzheimer's parents. Neurobiology of aging. 2012 Academic Article GET IT
Times cited: 47
Selective CDK4/6 inhibition with tumor responses by PD0332991 in patients with mantle cell lymphoma. Blood. 2012 Academic Article GET IT
Times cited: 256
Radioiodinated metaiodobenzylguanidine (MIBG): radiochemistry, biology, and pharmacology. Seminars in nuclear medicine. 2011 Review GET IT
Times cited: 77
A broad overview of positron emission tomography radiopharmaceuticals and clinical applications: what is new?. Seminars in nuclear medicine. 2011 Review GET IT
Times cited: 85
Guest Editorial: new PET radiopharmaceuticals as molecular imaging probes. Seminars in nuclear medicine. 2011 Editorial Article GET IT
Times cited: 1
Positron emission tomography radiopharmaceuticals for imaging brain Beta-amyloid. Seminars in nuclear medicine. 2011 Review GET IT
Times cited: 73
Maternal age affects brain metabolism in adult children of mothers affected by Alzheimer's disease. Neurobiology of aging. 2011 Academic Article GET IT
Times cited: 9
Imaging inflammation in a patient with epilepsy due to focal cortical dysplasia. 2011 GET IT
Times cited: 55
Safety and maximum tolerated dose of superselective intraarterial cerebral infusion of bevacizumab after osmotic blood-brain barrier disruption for recurrent malignant glioma. Clinical article. Journal of neurosurgery. 2010 Academic Article GET IT
Times cited: 117
Altered biodistribution of radiopharmaceuticals: role of radiochemical/pharmaceutical purity, physiological, and pharmacologic factors. Seminars in nuclear medicine. 2010 Review GET IT
Times cited: 76
Increased fibrillar amyloid-{beta} burden in normal individuals with a family history of late-onset Alzheimer's. Proceedings of the National Academy of Sciences of the United States of America. 2010 Academic Article GET IT
Times cited: 115
Anti-prostate-specific membrane antigen-based radioimmunotherapy for prostate cancer. Cancer. 2010 Academic Article GET IT
Times cited: 122
PET imaging of leptin biodistribution and metabolism in rodents and primates. Cell metabolism. 2009 Academic Article GET IT
Times cited: 45
Clinically proven radiopharmaceuticals for infection imaging: mechanisms and applications. Seminars in nuclear medicine. 2009 Review GET IT
Times cited: 69
Site-specific (18)F-labeling of the protein hormone leptin using a general two-step ligation procedure. Journal of the American Chemical Society. 2008 Academic Article GET IT
Times cited: 64
Metastatic human colonic carcinoma: molecular imaging with pretargeted SPECT and PET in a mouse model. Radiology. 2008 Academic Article GET IT
Times cited: 46
(18)F-labeled positron emission tomographic radiopharmaceuticals in oncology: an overview of radiochemistry and mechanisms of tumor localization. Seminars in nuclear medicine. 2007 Review GET IT
Times cited: 174
Investigation of the role of the base in the synthesis of [18F]FLT. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. 2007 Academic Article GET IT
Times cited: 31
Vascular targeted therapy with anti-prostate-specific membrane antigen monoclonal antibody J591 in advanced solid tumors. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2007 Academic Article GET IT
Times cited: 198
Dose-attenuated radioimmunotherapy with tositumomab and iodine 131 tositumomab in patients with recurrent non-Hodgkin's lymphoma (NHL) and extensive bone marrow involvement. Leukemia & lymphoma. 2007 Academic Article GET IT
Times cited: 11
Possible axonal regrowth in late recovery from the minimally conscious state. The Journal of clinical investigation. 2006 Academic Article GET IT
Times cited: 277
Clinical utility of radiolabeled monoclonal antibodies in prostate cancer. Clinical genitourinary cancer. 2006 Review GET IT
Times cited: 23
Subsequent therapy can be administered after tositumomab and iodine I-131 tositumomab for non-Hodgkin lymphoma. Cancer. 2006 Academic Article GET IT
Times cited: 34
Radioimmunotherapy of prostate cancer using 90Y- and 177Lu-labeled J591 monoclonal antibodies: effect of multiple treatments on myelotoxicity. Clinical cancer research : an official journal of the American Association for Cancer Research. 2005 Academic Article GET IT
Times cited: 112
Abbreviated chemotherapy with fludarabine followed by tositumomab and iodine I 131 tositumomab for untreated follicular lymphoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2005 Academic Article GET IT
Times cited: 145
Prediction of myelotoxicity based on bone marrow radiation-absorbed dose: radioimmunotherapy studies using 90Y- and 177Lu-labeled J591 antibodies specific for prostate-specific membrane antigen. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2005 Academic Article GET IT
Times cited: 83
Phase I trial of 177lutetium-labeled J591, a monoclonal antibody to prostate-specific membrane antigen, in patients with androgen-independent prostate cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2005 Academic Article GET IT
Times cited: 428
Pharmacokinetics and biodistribution of 111In- and 177Lu-labeled J591 antibody specific for prostate-specific membrane antigen: prediction of 90Y-J591 radiation dosimetry based on 111In or 177Lu?. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2005 Academic Article GET IT
Times cited: 127
Determination of immunoreactive fraction of radiolabeled monoclonal antibodies: what is an appropriate method?. Cancer biotherapy & radiopharmaceuticals. 2004 Academic Article GET IT
Times cited: 29
Phase I trial of yttrium-90-labeled anti-prostate-specific membrane antigen monoclonal antibody J591 for androgen-independent prostate cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2004 Academic Article GET IT
Times cited: 292
Radioimmunotherapy of prostate cancer in human xenografts using monoclonal antibodies specific to prostate specific membrane antigen (PSMA): studies in nude mice. The Prostate. 2004 Academic Article GET IT
Times cited: 56
Clinical use of monoclonal antibody HuJ591 therapy: targeting prostate specific membrane antigen. The Journal of urology. 2003 Review GET IT
Times cited: 122
Targeting metastatic prostate cancer with radiolabeled monoclonal antibody J591 to the extracellular domain of prostate specific membrane antigen. The Journal of urology. 2003 Academic Article GET IT
Times cited: 207
Targeted systemic therapy of prostate cancer with a monoclonal antibody to prostate-specific membrane antigen. Seminars in oncology. 2003 Review GET IT
Times cited: 136
Radiolabeled monoclonal antibodies specific to the extracellular domain of prostate-specific membrane antigen: preclinical studies in nude mice bearing LNCaP human prostate tumor. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2003 Academic Article GET IT
Times cited: 164
The utility of monoclonal antibodies in the imaging of prostate cancer. Seminars in urologic oncology. 2002 Review GET IT
Times cited: 40
Comparison of fluorine-18 fluorodeoxyglucose positron emission tomography and Ga-67 scintigraphy in evaluation of lymphoma. Cancer. 2002 Academic Article GET IT
Times cited: 199
Validation in the canine model of a new non-invasive method of measuring coronary blood flow reserve: split dose thallium-201 rest/stress imaging. The international journal of cardiovascular imaging. 2001 Academic Article GET IT
Thyroid uptake of liquid versus capsule 131I tracers in hyperthyroid patients treated with liquid 131I. Thyroid : official journal of the American Thyroid Association. 1999 Academic Article GET IT
Times cited: 9
Dorsal striatal size, shape, and metabolic rate in never-medicated and previously medicated schizophrenics performing a verbal learning task. Archives of general psychiatry. 1998 Academic Article GET IT
Times cited: 145
Atherosclerosis: imaging techniques and the evolving role of nuclear medicine. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1997 Review GET IT
Times cited: 139
Technetium-99m-labeled chemotactic peptides: specific for imaging infection?. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1997 Editorial Article GET IT
Times cited: 21
Scintigraphic evaluation of Tc-99m-low-density lipoprotein (LDL) distribution in patients with Gaucher disease. Clinical genetics. 1997 Academic Article GET IT
Times cited: 8
SPECT studies of D2 occupancy in low-dose haloperidol treatment. The American journal of psychiatry. 1997 Letter GET IT
Times cited: 2
Effect of haloperidol dose on iodine-123-IBZM brain SPECT imaging in schizophrenic patients. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1997 Academic Article GET IT
Times cited: 8
Pre-clinical evaluation of technetium-99m platelet receptor-binding peptide. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1997 Academic Article GET IT
Times cited: 34
Evaluation of four radiopharmaceuticals for imaging inflammation in a rabbit model of arthritis. Annals of nuclear medicine. 1996 Academic Article GET IT
Times cited: 5
A new iterative reconstruction technique for attenuation correction in high-resolution positron emission tomography. European journal of nuclear medicine. 1996 Academic Article GET IT
Times cited: 21
Preclinical evaluation of technetium-99m-labeled somatostatin receptor-binding peptides. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1996 Academic Article GET IT
Times cited: 128
Postoperative intravenous infusion of alprostadil (PGE1) does not improve renal function in hepatic transplant recipients. Journal of the American College of Surgeons. 1996 Academic Article GET IT
Times cited: 20
Technetium-99m-white blood cell-specific imaging agent developed from platelet factor 4 to detect infection. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1996 Academic Article GET IT
Times cited: 53
Cerebral versus myocardial stress perfusion imaging: role of pharmacological intervention in the diagnostic assessment of flow reserve. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1994 Editorial Article GET IT
Times cited: 2
PET studies in psychiatry: validity, accuracy and future. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1994 Editorial Article GET IT
Chemistry and biological behavior of samarium-153 and rhenium-186-labeled hydroxyapatite particles: potential radiopharmaceuticals for radiation synovectomy. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1993 Academic Article GET IT
Times cited: 100
Effect of blood-brain barrier and blood-tumor barrier modification on central nervous system liposomal uptake. Cancer investigation. 1993 Academic Article GET IT
Times cited: 31
Organ perfusion by dynamic scintigraphy convection-diffusion tracer kinetics in a phantom. The American journal of physiology. 1992 Academic Article GET IT
Times cited: 4
Radionuclide diagnosis of vertebral osteomyelitis: indium-111-leukocyte and technetium-99m-methylene diphosphonate bone scintigraphy. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1991 Academic Article GET IT
Times cited: 145
Indium-111-labeled leukocyte scintigraphy in hemodialysis access-site infection. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1990 Academic Article GET IT
Times cited: 31
99mTc-low density lipoprotein: intracellularly trapped radiotracer for noninvasive imaging of low density lipoprotein metabolism in vivo. Seminars in nuclear medicine. 1990 Review GET IT
Times cited: 31
Dynamic monitoring of platelet deposition on severely damaged vessel wall in flowing blood. Effects of different stenoses on thrombus growth. Arteriosclerosis (Dallas, Tex.). 1990 Academic Article GET IT
Times cited: 73
In vivo stability of ferric hydroxide macroaggregates (FHMA). Is it a suitable carrier for radionuclides used in synovectomy?. International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology. 1990 Academic Article GET IT
Times cited: 14
Noninvasive imaging of 99mtechnetium-labeled low density lipoprotein uptake by tendon xanthomas in hypercholesterolemic patients. Arteriosclerosis (Dallas, Tex.). 1990 Academic Article GET IT
Times cited: 36
Multidrug resistance in a human leukemic cell line selected for resistance to trimetrexate. Cancer research. 1989 Academic Article GET IT
Times cited: 50
Value of blood-pool subtraction in cardiac indium-111-labeled platelet imaging. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1989 Academic Article GET IT
Times cited: 4
Systemic biodistribution of radioiodinated interleukin-2 in the rat. Journal of biological response modifiers. 1989 Academic Article GET IT
Times cited: 22
Technetium-99m ECD: a new brain imaging agent: in vivo kinetics and biodistribution studies in normal human subjects. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1989 Academic Article GET IT
Times cited: 143
Detection of abnormalities in febrile AIDS patients with In-111-labeled leukocyte and Ga-67 scintigraphy. Radiology. 1989 Academic Article GET IT
Times cited: 56
Low-density lipoprotein (LDL) distribution shown by 99mtechnetium-LDL imaging in patients with myeloproliferative diseases. Annals of internal medicine. 1989 Academic Article GET IT
Times cited: 15
Platelet thrombus formation on collagen type I. A model of deep vessel injury. Influence of blood rheology, von Willebrand factor, and blood coagulation. Circulation. 1988 Academic Article GET IT
Times cited: 132
Radiotracers for low density lipoprotein biodistribution studies in vivo: technetium-99m low density lipoprotein versus radioiodinated low density lipoprotein preparations. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1988 Academic Article GET IT
Times cited: 51
Low density lipoprotein receptor-independent hepatic uptake of a synthetic, cholesterol-scavenging lipoprotein: implications for the treatment of receptor-deficient atherosclerosis. Proceedings of the National Academy of Sciences of the United States of America. 1988 Academic Article GET IT
Times cited: 32
Indium-111 platelet kinetics in normal human subjects: tropolone versus oxine methods. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1986 Academic Article GET IT
Times cited: 15
Studies of the hepatocellular uptake of the hepatobiliary scintiscanning agent 99mTc-DISIDA. Journal of hepatology. 1986 Academic Article GET IT
Times cited: 29
67Ga-transferrin and 67Ga-lactoferrin binding to tumor cells: specific versus nonspecific glycoprotein-cell interaction. European journal of nuclear medicine. 1983 Academic Article GET IT
Times cited: 21
Non-specific binding of transferrin and lactoferrin to polystyrene culture tubes: role of the radioligand. European journal of nuclear medicine. 1983 Academic Article GET IT
Times cited: 3
Radiochemical analysis of Tc-99m human serum albumin with high-pressure liquid chromatography: concise communication. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1982 Academic Article GET IT
Times cited: 6
Effect of pH on tumor cell uptake of radiogallium in vitro and in vivo. European journal of nuclear medicine. 1982 Academic Article GET IT
Times cited: 15
The mechanism of tumor localization of gallium-67 citrate: role of transferrin binding and effect of tumor pH. International journal of nuclear medicine and biology. 1981 Academic Article GET IT
Times cited: 39
Radiogallium localization in tumors: blood binding and transport and the role of transferrin. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1980 Academic Article GET IT
Times cited: 107
Quality control of technetium-labelled lung imaging agents. International journal of nuclear medicine and biology. 1977 Academic Article GET IT
Times cited: 2

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Research

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Funding awarded

Sex Differences in the Molecular Determinants of Alzheimer’s Disease Risk awarded by National Institute on Aging Co-Investigator 2018 - 2024

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Background

education and training

Ph.D., University of Southern California 1980
M.S., Andhra University (India) 1971
B.S., Andhra University (India) 1969

Contact

full name

Shankar Vallabhajosula

primary email

svallabh@med.cornell.edu

VIVO Weill Cornell Medical College

Shankar Vallabhajosula Professor Emeritus of Radiochemistry and Radiopharmacy in Radiology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email