Ince, Tan

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Cell-of-Origin Targeted Drug Repurposing for Triple-Negative and Inflammatory Breast Carcinoma with HDAC and HSP90 Inhibitors Combined with Niclosamide. Cancers. 2023 Academic Article GET IT
Times cited: 9152
Estrone, the major postmenopausal estrogen, binds ERa to induce SNAI2, epithelial-to-mesenchymal transition, and ER+ breast cancer metastasis. Cell reports. 2022 Academic Article GET IT
Times cited: 2
ZNF92, an unexplored transcription factor with remarkably distinct breast cancer over-expression associated with prognosis and cell-of-origin. NPJ breast cancer. 2022 Academic Article GET IT
Times cited: 12
Targeting BET Proteins BRD2 and BRD3 in Combination with PI3K-AKT Inhibition as a Therapeutic Strategy for Ovarian Clear Cell Carcinoma. Molecular cancer therapeutics. 2021 Academic Article GET IT
Times cited: 14
Transient commensal clonal interactions can drive tumor metastasis. Nature communications. 2020 Academic Article GET IT
Times cited: 17
BET, SRC, and BCL2 family inhibitors are synergistic drug combinations with PARP inhibitors in ovarian cancer. EBioMedicine. 2020 Academic Article GET IT
Times cited: 17
The Major Pre- and Postmenopausal Estrogens Play Opposing Roles in Obesity-Driven Mammary Inflammation and Breast Cancer Development. Cell metabolism. 2020 Academic Article GET IT
Times cited: 39
HDAC7 regulates histone 3 lysine 27 acetylation and transcriptional activity at super-enhancer-associated genes in breast cancer stem cells. Oncogene. 2019 Academic Article GET IT
Times cited: 68
Ovarian Cancer Treatment Stratification Using Ex Vivo Drug Sensitivity Testing. Anticancer research. 2019 Academic Article GET IT
Times cited: 7
Dual Src and MEK Inhibition Decreases Ovarian Cancer Growth and Targets Tumor Initiating Stem-Like Cells. Clinical cancer research : an official journal of the American Association for Cancer Research. 2018 Academic Article GET IT
Times cited: 44
Ectopic protein interactions within BRD4-chromatin complexes drive oncogenic megadomain formation in NUT midline carcinoma. Proceedings of the National Academy of Sciences of the United States of America. 2017 Academic Article GET IT
Times cited: 78
VEGFA activates an epigenetic pathway upregulating ovarian cancer-initiating cells. EMBO molecular medicine. 2017 Academic Article GET IT
Times cited: 46
Identification of a cancer stem cell-specific function for the histone deacetylases, HDAC1 and HDAC7, in breast and ovarian cancer. Oncogene. 2016 Academic Article GET IT
Times cited: 113
Reference-free deconvolution of DNA methylation data and mediation by cell composition effects. BMC bioinformatics. 2016 Academic Article GET IT
Times cited: 151
Breast cancers from black women exhibit higher numbers of immunosuppressive macrophages with proliferative activity and of crown-like structures associated with lower survival compared to non-black Latinas and Caucasians. Breast cancer research and treatment. 2016 Academic Article GET IT
Times cited: 73
Vitamin D and androgen receptor-targeted therapy for triple-negative breast cancer. Breast cancer research and treatment. 2016 Academic Article GET IT
Times cited: 47
Corrigendum: Chaperone-mediated autophagy degrades mutant p53. Genes & development. 2016 Article GET IT
Erratum to: PI3K/mTOR inhibition can impair tumor invasion and metastasis in vivo despite a lack of antiproliferative action in vitro: implications for targeted therapy. Breast cancer research and treatment. 2016 Article GET IT
Times cited: 1
Interactions between Adipocytes and Breast Cancer Cells Stimulate Cytokine Production and Drive Src/Sox2/miR-302b-Mediated Malignant Progression. Cancer research. 2016 Academic Article GET IT
Times cited: 124
MAPK Activation Predicts Poor Outcome and the MEK Inhibitor, Selumetinib, Reverses Antiestrogen Resistance in ER-Positive High-Grade Serous Ovarian Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2015 Academic Article GET IT
Times cited: 44
Of mice and women: a comparative tissue biology perspective of breast stem cells and differentiation. Journal of mammary gland biology and neoplasia. 2015 Review GET IT
Times cited: 36
Heat shock factor 1 induces cancer stem cell phenotype in breast cancer cell lines. Breast cancer research and treatment. 2015 Academic Article GET IT
Times cited: 31
Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours. Nature communications. 2015 Academic Article GET IT
Times cited: 129
Thrombospondin-1 repression is mediated via distinct mechanisms in fibroblasts and epithelial cells. Oncogene. 2015 Article GET IT
Times cited: 3
Cytoplasmic p27 promotes epithelial-mesenchymal transition and tumor metastasis via STAT3-mediated Twist1 upregulation. Oncogene. 2015 Academic Article GET IT
Times cited: 92
Normal cell phenotypes of breast epithelial cells provide the foundation of a breast cancer taxonomy. Expert review of anticancer therapy. 2014 Editorial Article GET IT
Times cited: 16
Thrombospondin-1 repression is mediated via distinct mechanisms in fibroblasts and epithelial cells. Oncogene. 2014 Academic Article GET IT
Times cited: 18
Mesenchymal gene program-expressing ovarian cancer spheroids exhibit enhanced mesothelial clearance. The Journal of clinical investigation. 2014 Academic Article GET IT
Times cited: 98
Taxonomy of breast cancer based on normal cell phenotype predicts outcome. The Journal of clinical investigation. 2014 Academic Article GET IT
Times cited: 148
Rb suppresses collective invasion, circulation and metastasis of breast cancer cells in CD44-dependent manner. PloS one. 2013 Academic Article GET IT
Times cited: 17
Gene expression signature of normal cell-of-origin predicts ovarian tumor outcomes. PloS one. 2013 Academic Article GET IT
Times cited: 37
A genome-wide siRNA screen identifies proteasome addiction as a vulnerability of basal-like triple-negative breast cancer cells. Cancer cell. 2013 Academic Article GET IT
Times cited: 123
Chaperone-mediated autophagy degrades mutant p53. Genes & development. 2013 Academic Article GET IT
Times cited: 145
Induced pluripotent stem cells with a mitochondrial DNA deletion. 2013 GET IT
Times cited: 80
PI3K/mTOR inhibition can impair tumor invasion and metastasis in vivo despite a lack of antiproliferative action in vitro: implications for targeted therapy. Breast cancer research and treatment. 2013 Academic Article GET IT
Times cited: 794
Retraction. Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis. Cancer cell. 2013 Article GET IT
Defined, serum-free conditions for in vitro culture of primary human T-ALL blasts. Leukemia. 2012 Letter GET IT
Times cited: 11
Src Inhibition with saracatinib reverses fulvestrant resistance in ER-positive ovarian cancer models in vitro and in vivo. Clinical cancer research : an official journal of the American Association for Cancer Research. 2012 Academic Article GET IT
Times cited: 52
HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers. Cell. 2012 Academic Article GET IT
Times cited: 489
Reproducibility of endometrial intraepithelial neoplasia diagnosis is good, but influenced by the diagnostic style of pathologists. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2012 Academic Article GET IT
Times cited: 25
High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer. Proceedings of the National Academy of Sciences of the United States of America. 2011 Academic Article GET IT
Times cited: 224
Ovarian cancer spheroids use myosin-generated force to clear the mesothelium. Cancer discovery. 2011 Academic Article GET IT
Times cited: 216
What is the oncologic risk of stem cell treatment for heart disease?. Circulation research. 2011 Editorial Article GET IT
Times cited: 44
Differentiation of NUT midline carcinoma by epigenomic reprogramming. Cancer research. 2011 Academic Article GET IT
Times cited: 157
Tubal and ovarian pathways to pelvic epithelial cancer: a pathological perspective. Histopathology. 2009 Letter GET IT
Times cited: 20
Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells. Nature biotechnology. 2009 Academic Article GET IT
Times cited: 406
Fatty acid binding protein 4 is a target of VEGF and a regulator of cell proliferation in endothelial cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2009 Academic Article GET IT
Times cited: 228
Squamous morules are functionally inert elements of premalignant endometrial neoplasia. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2008 Academic Article GET IT
Times cited: 40
Do-it-yourself (DIY) pathology. Nature biotechnology. 2008 Letter GET IT
Times cited: 38
Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression. Cell. 2008 Academic Article GET IT
Times cited: 352
Systemic endocrine instigation of indolent tumor growth requires osteopontin. Cell. 2008 Academic Article GET IT
Times cited: 349
Tubal and ovarian pathways to pelvic epithelial cancer: a pathological perspective. Histopathology. 2008 Review GET IT
Times cited: 85
Human embryonic stem cell derivation from poor-quality embryos. Nature biotechnology. 2008 Academic Article GET IT
Times cited: 86
Reprogramming of human somatic cells to pluripotency with defined factors. Nature. 2007 Academic Article GET IT
Times cited: 2400
Over 60% of NIH extramural funding involves animal-related research. Veterinary pathology. 2007 Letter GET IT
Times cited: 14
The terminology of teratocarcinomas and teratomas. Nature biotechnology. 2007 Letter GET IT
Times cited: 31
Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes. Cancer cell. 2007 Academic Article GET IT
Times cited: 255
From whence will they come? - A perspective on the acute shortage of pathologists in biomedical research. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. 2007 Letter GET IT
Times cited: 27
The distal fallopian tube: a new model for pelvic serous carcinogenesis. Current opinion in obstetrics & gynecology. 2007 Review GET IT
Times cited: 385
I enjoyed the article about reserve cells. Human pathology. 2005 Letter GET IT
Prediction of endometrial carcinoma by subjective endometrial intraepithelial neoplasia diagnosis. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2005 Academic Article GET IT
Times cited: 119
Microglandular hyperplasia: a model for the de novo emergence and evolution of endocervical reserve cells. Human pathology. 2005 Academic Article GET IT
Times cited: 35
Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer. Nature medicine. 2004 Academic Article GET IT
Times cited: 499
Uterine leiomyomata with t(10;17) disrupt the histone acetyltransferase MORF. Cancer research. 2004 Academic Article GET IT
Times cited: 88
Telomerase: promise and challenge. Human pathology. 2004 Editorial Article GET IT
Biomarkers in diagnostic obstetric and gynecologic pathology: a review. Advances in anatomic pathology. 2003 Review GET IT
Times cited: 46
Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis. Cancer cell. 2003 Academic Article GET IT
Times cited: 284
Loss of p63 expression is associated with tumor progression in bladder cancer. The American journal of pathology. 2002 Academic Article GET IT
Times cited: 222
p63 Coordinates anogenital modeling and epithelial cell differentiation in the developing female urogenital tract. The American journal of pathology. 2002 Academic Article GET IT
Times cited: 89
Functional genomics and the breast cancer problem. Cancer cell. 2002 Review GET IT
Times cited: 18
Optimization of a versatile in vitro transcription assay for the expression of multiple start site TATA-less promoters. Biochemistry. 2001 Academic Article GET IT
Times cited: 12
Molecular identification of latent precancers in histologically normal endometrium. Cancer research. 2001 Academic Article GET IT
Times cited: 190
Transcriptional repression by p53 through direct binding to a novel DNA element. The Journal of biological chemistry. 2001 Academic Article GET IT
Times cited: 135
Surrogate biomarkers of HPV infection in cervical neoplasia screening and diagnosis. Advances in anatomic pathology. 2001 Review GET IT
Times cited: 99
Stable transfection of the P-glycoprotein promoter reproduces the endogenous overexpression phenotype: the role of MED-1. Cancer research. 1996 Academic Article GET IT
Times cited: 16
A conserved downstream element defines a new class of RNA polymerase II promoters. The Journal of biological chemistry. 1995 Academic Article GET IT
Times cited: 138
Differential utilization of multiple transcription start points accompanies the overexpression of the P-glycoprotein-encoding gene in Chinese hamster lung cells. Gene. 1995 Academic Article GET IT
Times cited: 25

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Research

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Co-investigator Network

Funding awarded

Isolation and Characterization of Metastatic Breast Cancer Cell-of-Origin awarded by Breast Cancer Research Foundation, Inc. Principal Investigator 2021 - 2023

The role of type 2 inflammation in the initiation and progression of metaplastic differentiation and neoplastic transformation of gastric epithelia awarded by National Cancer Institute Principal Investigator Subaward 2020 - 2025
NRG ONCOLOGY NETWORK GROUP OPERATIONS CENTER awarded by National Cancer Institute Principal Investigator Subaward 2022 - 2024

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Background

education and training

Ph.D., Cornell University 1996
M.D., Hacettepe University Faculty of Medicine (Turkey) 1988

Contact

full name

Tan Ince

primary email

tai9015@med.cornell.edu

webpage

Clinical Profile

VIVO Weill Cornell Medical College

Tan Ince Professor of Pathology and Laboratory Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage