Vartanian, Tim

Publications

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selected publications

Demographics and baseline disease characteristics of Black and Hispanic patients with multiple sclerosis in the open-label, single-arm, multicenter, phase IV CHIMES trial. Multiple sclerosis and related disorders. 2023 Academic Article GET IT
Understanding humoral immunity and multiple sclerosis severity in Black, and Latinx patients. Frontiers in immunology. 2023 Review GET IT
Epsilon toxin-producing Clostridium perfringens colonize the multiple sclerosis gut microbiome overcoming CNS immune privilege. The Journal of clinical investigation. 2023 Academic Article GET IT
Times cited: 2
Antigen-presenting innate lymphoid cells orchestrate neuroinflammation. Nature. 2021 Academic Article GET IT
Times cited: 15
A Multi-Ligand Imaging Study Exploring GABAergic Receptor Expression and Inflammation in Multiple Sclerosis. Molecular imaging and biology. 2020 Academic Article GET IT
Times cited: 4
Impact of Lesion Location on Longitudinal Myelin Water Fraction Change in Chronic Multiple Sclerosis Lesions. Journal of neuroimaging : official journal of the American Society of Neuroimaging. 2020 Academic Article GET IT
Times cited: 5
Clostridium perfringens epsilon toxin induces blood brain barrier permeability via caveolae-dependent transcytosis and requires expression of MAL. PLoS pathogens. 2019 Academic Article GET IT
Times cited: 16
Black African and Latino/a identity correlates with increased plasmablasts in MS. Neurology(R) neuroimmunology & neuroinflammation. 2019 Academic Article GET IT
Times cited: 6
Clostridium perfringens Epsilon Toxin Compromises the Blood-Brain Barrier in a Humanized Zebrafish Model. iScience. 2019 Academic Article GET IT
Times cited: 9
A Novel Panel of Rabbit Monoclonal Antibodies and Their Diverse Applications Including Inhibition of Clostridium perfringens Epsilon Toxin Oligomerization. Antibodies (Basel, Switzerland). 2018 Academic Article GET IT
Times cited: 147
Induction of disease remission with one cycle of alemtuzumab in relapsing-remitting MS. Journal of neurology. 2018 Academic Article GET IT
Times cited: 1
Thrombocytopenia at the time of alemtuzumab infusion in relapsing-remitting multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England). 2017 Letter GET IT
Times cited: 1
MRI Analysis of White Matter Myelin Water Content in Multiple Sclerosis: A Novel Approach Applied to Finding Correlates of Cortical Thinning. Frontiers in neuroscience. 2017 Academic Article GET IT
Times cited: 4851
Reduction of PK11195 uptake observed in multiple sclerosis lesions after natalizumab initiation. Multiple sclerosis and related disorders. 2017 Academic Article GET IT
Times cited: 23
Immediate transient thrombocytopenia at the time of alemtuzumab infusion in multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England). 2017 Academic Article GET IT
Times cited: 9
Oral Multiple Sclerosis Drugs Inhibit the In vitro Growth of Epsilon Toxin Producing Gut Bacterium, Clostridium perfringens. Frontiers in cellular and infection microbiology. 2017 Academic Article GET IT
Times cited: 41
Differential Impact of Multiple Sclerosis on Cortical and Deep Gray Matter Structures in African Americans and Caucasian Americans. Journal of neuroimaging : official journal of the American Society of Neuroimaging. 2016 Academic Article GET IT
Times cited: 15
A study of patients with aggressive multiple sclerosis at disease onset. Neuropsychiatric disease and treatment. 2016 Academic Article GET IT
Times cited: 9
Measuring longitudinal myelin water fraction in new multiple sclerosis lesions. NeuroImage. Clinical. 2015 Academic Article GET IT
Times cited: 46
Relapses in multiple sclerosis: Relationship to disability. Multiple sclerosis and related disorders. 2015 Review GET IT
Times cited: 34
Clostridium perfringens Epsilon Toxin Causes Selective Death of Mature Oligodendrocytes and Central Nervous System Demyelination. mBio. 2015 Academic Article GET IT
Times cited: 60
The Myelin and Lymphocyte Protein MAL Is Required for Binding and Activity of Clostridium perfringens ε-Toxin. PLoS pathogens. 2015 Academic Article GET IT
Times cited: 57
Re-evaluating the treatment of acute optic neuritis. Journal of neurology, neurosurgery, and psychiatry. 2014 Review GET IT
Times cited: 23
Isolation of Clostridium perfringens type B in an individual at first clinical presentation of multiple sclerosis provides clues for environmental triggers of the disease. PloS one. 2013 Academic Article GET IT
Times cited: 149
T2 prep three-dimensional spiral imaging with efficient whole brain coverage for myelin water quantification at 1.5 tesla. Magnetic resonance in medicine. 2012 Academic Article GET IT
Times cited: 56
Nna1 mediates Purkinje cell dendritic development via lysyl oxidase propeptide and NF-κB signaling. Neuron. 2010 Academic Article GET IT
Times cited: 58
Carbon monoxide suppresses membrane expression of TLR4 via myeloid differentiation factor-2 in betaTC3 cells. Journal of immunology (Baltimore, Md. : 1950). 2010 Academic Article GET IT
Times cited: 19
Hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2. Proceedings of the National Academy of Sciences of the United States of America. 2010 Academic Article GET IT
Times cited: 282
A clear and present danger: endogenous ligands of Toll-like receptors. Neuromolecular medicine. 2009 Review GET IT
Times cited: 77
T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS. Proceedings of the National Academy of Sciences of the United States of America. 2008 Academic Article GET IT
Times cited: 267
Clinical and neuropathologic findings in a woman with the FMR1 premutation and multiple sclerosis. 2008 GET IT
Times cited: 63
More on melanoma with transdifferentiation. The New England journal of medicine. 2008 Letter GET IT
Times cited: 25
Melanoma complicating treatment with natalizumab for multiple sclerosis. The New England journal of medicine. 2008 Letter GET IT
Times cited: 91
Toll-like receptor 3 is a potent negative regulator of axonal growth in mammals. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007 Academic Article GET IT
Times cited: 181
The immunogenicity of disease-modifying therapies for multiple sclerosis: clinical implications for neurologists. The neurologist. 2007 Review GET IT
Times cited: 21
Myosin Va controls oligodendrocyte morphogenesis and myelination. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007 Academic Article GET IT
Times cited: 34
WAVE1 and regulation of actin nucleation in myelination. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 2007 Review GET IT
Times cited: 21
TLR8: an innate immune receptor in brain, neurons and axons. Cell cycle (Georgetown, Tex.). 2007 Review GET IT
Times cited: 87
Treating multiple sclerosis in the natalizumab era: risks, benefits, clinical decision making, and a comparison between North American and European Union practices. Reviews in neurological diseases. 2007 Review GET IT
Times cited: 5
Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis. The Journal of cell biology. 2006 Academic Article GET IT
Times cited: 222
A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyD88 pathway in microglia. Journal of immunology (Baltimore, Md. : 1950). 2006 Academic Article GET IT
Times cited: 142
WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006 Academic Article GET IT
Times cited: 79
Purkinje neuron degeneration in nervous (nr) mutant mice is mediated by a metabolic pathway involving excess tissue plasminogen activator. Proceedings of the National Academy of Sciences of the United States of America. 2006 Academic Article GET IT
Times cited: 25
High-resolution anatomic, diffusion tensor, and magnetization transfer magnetic resonance imaging of the optic chiasm at 3T. Journal of magnetic resonance imaging : JMRI. 2005 Academic Article GET IT
Times cited: 27
Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes. Proceedings of the National Academy of Sciences of the United States of America. 2005 Academic Article GET IT
Times cited: 319
The ErbB4 neuregulin receptor mediates suppression of oligodendrocyte maturation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005 Academic Article GET IT
Times cited: 61
Neutralizing antibodies to disease-modifying agents in the treatment of multiple sclerosis. Neurology. 2004 Review GET IT
Times cited: 28
Impact of neutralizing antibodies on the clinical efficacy of interferon beta in multiple sclerosis. Journal of neurology. 2004 Review GET IT
Times cited: 32
Integrin-linked kinase is required for laminin-2-induced oligodendrocyte cell spreading and CNS myelination. The Journal of cell biology. 2003 Academic Article GET IT
Times cited: 134
Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway. Proceedings of the National Academy of Sciences of the United States of America. 2003 Academic Article GET IT
Times cited: 857
An examination of the results of the EVIDENCE, INCOMIN, and phase III studies of interferon beta products in the treatment of multiple sclerosis. Clinical therapeutics. 2003 Review GET IT
Times cited: 30
Increased expression of epidermal growth factor receptor induces sequestration of extracellular signal-related kinases and selective attenuation of specific epidermal growth factor-mediated signal transduction pathways. Molecular cancer research : MCR. 2003 Academic Article GET IT
Times cited: 35
Localization of Nogo-A and Nogo-66 receptor proteins at sites of axon-myelin and synaptic contact. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2002 Academic Article GET IT
Times cited: 332
The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2002 Academic Article GET IT
Times cited: 557
Sonic hedgehog is required during an early phase of oligodendrocyte development in mammalian brain. Molecular and cellular neurosciences. 2001 Academic Article GET IT
Times cited: 77
The erbB2 gene is required for the development of terminally differentiated spinal cord oligodendrocytes. The Journal of cell biology. 2001 Academic Article GET IT
Times cited: 87
Epidermal growth factor receptor induced apoptosis: potentiation by inhibition of Ras signaling. FEBS letters. 2001 Academic Article GET IT
Times cited: 37
Growth factor control of CNS myelination. Developmental neuroscience. 2001 Academic Article GET IT
Times cited: 52
Neuregulin-induced association of Sos Ras exchange protein with HER2(erbB2)/HER3(erbB3) receptor complexes in Schwann cells through a specific Grb2-HER2(erbB2) interaction. Developmental neuroscience. 2001 Academic Article GET IT
Times cited: 10
Neuregulin: an oligodendrocyte growth factor absent in active multiple sclerosis lesions. Developmental neuroscience. 2001 Academic Article GET IT
Times cited: 68
The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-kappa B (NF-kappa B)-inducing kinase to activate NF-kappa B. Identification of a novel receptor-tyrosine kinase signalosome. The Journal of biological chemistry. 2000 Academic Article GET IT
Times cited: 115
Neuregulin induces the rapid association of focal adhesion kinase with the erbB2-erbB3 receptor complex in schwann cells. Biochemical and biophysical research communications. 2000 Academic Article GET IT
Times cited: 30
Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. Nature. 2000 Academic Article GET IT
Times cited: 1028
Failure of spinal cord oligodendrocyte development in mice lacking neuregulin. Proceedings of the National Academy of Sciences of the United States of America. 1999 Academic Article GET IT
Times cited: 144
Axonal neuregulin signals cells of the oligodendrocyte lineage through activation of HER4 and Schwann cells through HER2 and HER3. The Journal of cell biology. 1997 Academic Article GET IT
Times cited: 153
Interferon-gamma-induced oligodendrocyte cell death: implications for the pathogenesis of multiple sclerosis. Molecular medicine (Cambridge, Mass.). 1995 Academic Article GET IT
Times cited: 272
A role for the acetylcholine receptor-inducing protein ARIA in oligodendrocyte development. Proceedings of the National Academy of Sciences of the United States of America. 1994 Academic Article GET IT
Times cited: 96
Is multiple sclerosis an autoimmune disease?. Clinical neuroscience (New York, N.Y.). 1994 Review GET IT
Times cited: 15
Mediation by G proteins of signals that cause collapse of growth cones. Science (New York, N.Y.). 1993 Academic Article GET IT
Times cited: 170
GAP-43 as a plasticity protein in neuronal form and repair. Journal of neurobiology. 1992 Review GET IT
Times cited: 164
Oligodendrocyte-substratum adhesion activates the synthesis of specific lipid species involved in cell signaling. Journal of neuroscience research. 1992 Academic Article GET IT
Times cited: 22
Growth cone transduction: Go and GAP-43. Journal of cell science. Supplement. 1991 Review GET IT
Times cited: 31
Phosphorylation of myelin basic protein in intact oligodendrocytes: inhibition by galactosylsphingosine and cyclic AMP. Glia. 1989 Academic Article GET IT
Times cited: 27
Oligodendrocyte substratum adhesion modulates expression of adenylate cyclase-linked receptors. Proceedings of the National Academy of Sciences of the United States of America. 1988 Academic Article GET IT
Times cited: 51
Intracellular messengers. Influence of oligodendrocyte substratum adhesion. Annals of the New York Academy of Sciences. 1988 Academic Article GET IT
Times cited: 1
Regulation of GM2 ganglioside metabolism in cultured cells. Chemistry and physics of lipids. 1986 Review GET IT
Times cited: 3
Oligodendrocyte adhesion activates protein kinase C-mediated phosphorylation of myelin basic protein. Science (New York, N.Y.). 1986 Academic Article GET IT
Times cited: 101

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Research

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Funding awarded

Immune Privilege, CNS Autoimmunity, and Clostridium perfringens Epsilon Toxin awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2023 - 2028
Harboring the Initial Trigger of Multiple Sclerosis awarded by National Multiple Sclerosis Society Principal Investigator 2023 - 2026
Damage Associated Molecular Patterns and Regenerative Failure in MS awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2017 - 2023

Innate immune regulation of neuroinflammation awarded by National Institute of Allergy & Infectious Diseases Co-Investigator 2021 - 2026
No-Gd MRI for Monitoring Disease Status in Multiple Sclerosis awarded by National Institute of Neurological Disorders & Stroke Co-Investigator 2018 - 2023
Quantitative MRI of Lesion Iron and Myelin Repair awarded by National Multiple Sclerosis Society Co-Investigator 2016 - 2023

Ethnicity-Associated, Differential Cns Demyelinating Autoimmune Disease Severity: Reconciling Identity, Ancestry And Neurotoxic Antibody Response awarded by National Institute of Neurological Disorders & Stroke Key Personnel 2021 - 2023

Immunology of advancing disease among minorities with Multiple Sclerosis awarded by National Institute of Neurological Disorders & Stroke Principal Investigator Subaward 2021 - 2023

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Background

education and training

M.D., University of Chicago Pritzker School of Medicine 1988
Ph.D., University of Chicago 1987
B.A., Oakland University 1981

Contact

full name

Tim Vartanian

primary email

tiv2002@med.cornell.edu

webpage

Clinical Profile

VIVO Weill Cornell Medical College

Tim Vartanian Chief, Multiple Sclerosis and Neuro-Immunology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage