Chen, Yu

Publications

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selected publications

ETS factors in prostate cancer. Cancer letters. 2022 Review GET IT
Times cited: 9
Combined Inhibition of Gα_q and MEK Enhances Therapeutic Efficacy in Uveal Melanoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2020 Comment GET IT
Times cited: 21
Single-cell transcriptomics identifies a distinct luminal progenitor cell type in distal prostate invagination tips. Nature genetics. 2020 Academic Article GET IT
Times cited: 53
Basket trial of TRK inhibitors demonstrates efficacy in TRK fusion-positive cancers. Journal of hematology & oncology. 2018 Review GET IT
Times cited: 35
COP1/DET1/ETS axis regulates ERK transcriptome and sensitivity to MAPK inhibitors. The Journal of clinical investigation. 2018 Academic Article GET IT
Times cited: 24
GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma. Cell reports. 2018 Academic Article GET IT
Times cited: 45
SPOP mutation drives prostate neoplasia without stabilizing oncogenic transcription factor ERG. The Journal of clinical investigation. 2017 Academic Article GET IT
Times cited: 22
FOXF1 Defines the Core-Regulatory Circuitry in Gastrointestinal Stromal Tumor. Cancer discovery. 2017 Academic Article GET IT
Times cited: 39
Aberrant Activation of a Gastrointestinal Transcriptional Circuit in Prostate Cancer Mediates Castration Resistance. Cancer cell. 2017 Academic Article GET IT
Times cited: 45
Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation. Nature medicine. 2017 Academic Article GET IT
Times cited: 189
Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4. Nature medicine. 2017 Academic Article GET IT
Times cited: 198
Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway. Nature. 2017 Academic Article GET IT
Times cited: 862
ETV1-Positive Cells Give Rise to BRAF^V600E -Mutant Gastrointestinal Stromal Tumors. Cancer research. 2017 Academic Article GET IT
Times cited: 12
The potential of organoids in urological cancer research. Nature reviews. Urology. 2017 Review GET IT
Times cited: 61
SPOP Mutation Drives Prostate Tumorigenesis In Vivo through Coordinate Regulation of PI3K/mTOR and AR Signaling. Cancer cell. 2017 Academic Article GET IT
Times cited: 130
Stromal hedgehog signaling maintains smooth muscle and hampers micro-invasive prostate cancer. Disease models & mechanisms. 2016 Academic Article GET IT
Times cited: 27
N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer. Cancer cell. 2016 Academic Article GET IT
Times cited: 327
A Tmprss2-CreERT2 Knock-In Mouse Model for Cancer Genetic Studies on Prostate and Colon. PloS one. 2016 Academic Article GET IT
Times cited: 18
A Computational Drug Repositioning Approach for Targeting Oncogenic Transcription Factors. Cell reports. 2016 Academic Article GET IT
Times cited: 23
Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma. Nature genetics. 2016 Academic Article GET IT
Times cited: 189
Analogs of the novel phytohormone, strigolactone, trigger apoptosis and synergize with PARP inhibitors by inducing DNA damage and inhibiting DNA repair. Oncotarget. 2016 Academic Article GET IT
Times cited: 28
Organoid culture systems for prostate epithelial and cancer tissue. Nature protocols. 2016 Academic Article GET IT
Times cited: 352
The Molecular Taxonomy of Primary Prostate Cancer. Cell. 2015 Academic Article GET IT
Times cited: 1945
Alternative transcription initiation leads to expression of a novel ALK isoform in cancer. Nature. 2015 Academic Article GET IT
Times cited: 162
Integrative clinical genomics of advanced prostate cancer. Cell. 2015 Academic Article GET IT
Times cited: 2094
Organoid development in cancer genome discovery. Current opinion in genetics & development. 2015 Review GET IT
Times cited: 55
Prostate cancer organoids: a potential new tool for testing drug sensitivity. Expert review of anticancer therapy. 2015 Editorial Article GET IT
Times cited: 30
Combined inhibition of MAP kinase and KIT signaling synergistically destabilizes ETV1 and suppresses GIST tumor growth. Cancer discovery. 2015 Academic Article GET IT
Times cited: 95
Identifying actionable targets through integrative analyses of GEM model and human prostate cancer genomic profiling. Molecular cancer therapeutics. 2014 Academic Article GET IT
Times cited: 28
PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors. Nature genetics. 2014 Academic Article GET IT
Times cited: 386
Identification of multipotent luminal progenitor cells in human prostate organoid cultures. Cell. 2014 Academic Article GET IT
Times cited: 490
Organoid cultures derived from patients with advanced prostate cancer. Cell. 2014 Academic Article GET IT
Times cited: 983
Androgen receptor signaling regulates DNA repair in prostate cancers. Cancer discovery. 2013 Academic Article GET IT
Times cited: 345
ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss. Nature medicine. 2013 Academic Article GET IT
Times cited: 220
Overcoming mutation-based resistance to antiandrogens with rational drug design. eLife. 2013 Academic Article GET IT
Times cited: 308
β4 Integrin signaling induces expansion of prostate tumor progenitors. The Journal of clinical investigation. 2013 Academic Article GET IT
Times cited: 69
ARN-509: a novel antiandrogen for prostate cancer treatment. Cancer research. 2012 Academic Article GET IT
Times cited: 528
Prostate cancer in 2011: Hitting old targets better and identifying new targets. Nature reviews. Clinical oncology. 2012 Review GET IT
Times cited: 12
Visualization of the interstitial cells of cajal (ICC) network in mice. Journal of visualized experiments : JoVE. 2011 Academic Article GET IT
Times cited: 12
Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer. Cancer cell. 2011 Academic Article GET IT
Times cited: 917
ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours. Nature. 2010 Academic Article GET IT
Times cited: 243
Coordinate transcriptional regulation by ERG and androgen receptor in fusion-positive prostate cancers. Cancer cell. 2010 Comment GET IT
Times cited: 15
Anti-androgens and androgen-depleting therapies in prostate cancer: new agents for an established target. The Lancet. Oncology. 2009 Academic Article GET IT
Times cited: 265
Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science (New York, N.Y.). 2009 Academic Article GET IT
Times cited: 1755
Histone deacetylases are required for androgen receptor function in hormone-sensitive and castrate-resistant prostate cancer. Cancer research. 2009 Academic Article GET IT
Times cited: 149
Targeting the androgen receptor pathway in prostate cancer. Current opinion in pharmacology. 2008 Review GET IT
Times cited: 336
In situ biochemical demonstration that P-glycoprotein is a drug efflux pump with broad specificity. The Journal of cell biology. 2000 Academic Article GET IT
Times cited: 51
Tamoxifen inhibits acidification in cells independent of the estrogen receptor. Proceedings of the National Academy of Sciences of the United States of America. 1999 Academic Article GET IT
Times cited: 100
Defective acidification in human breast tumor cells and implications for chemotherapy. The Journal of experimental medicine. 1998 Academic Article GET IT
Times cited: 248

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Background

education and training

M.D., Cornell University Medical College 2002
Ph.D., The Rockefeller University 2001
A.B., Princeton University 1993

Contact

full name

Yu Chen

primary email

cheny1@mskcc.org

VIVO Weill Cornell Medical College

Yu Chen Associate Professor of Medicine

Publications

selected publications

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Background

education and training

Contact

full name

primary email