The Journal of pharmacology and experimental therapeutics

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Paving the Way for Cancer Therapy a Nano Step at a Time.. 384. 2023
Caspase-8 Regulates the Antimyeloma Activity of Bortezomib and Lenalidomide.. 379. 2021
A Retinoic Acid Receptor β ₂ Agonist Improves Cardiac Function in a Heart Failure Model.. 379. 2021
Differential Inhibition of Neuronal Sodium Channel Subtypes by the General Anesthetic Isoflurane.. 369. 2019
The HNF1α-Regulated LncRNA HNF1α-AS1 Is Involved in the Regulation of Cytochrome P450 Expression in Human Liver Tissues and Huh7 Cells.. 368. 2019
Amelioration of Diabetic Nephropathy Using a Retinoic Acid Receptor β2 Agonist.. 367. 2018
A Retinoic Acid β₂-Receptor Agonist Exerts Cardioprotective Effects.. 366. 2018
The Blood Pressure-Lowering Effect of 20-HETE Blockade in Cyp4a14(-/-) Mice Is Associated with Natriuresis.. 363. 2017
S1P receptor 1-Mediated Anti-Renin-Angiotensin System Cardioprotection: Pivotal Role of Mast Cell Aldehyde Dehydrogenase Type 2.. 362. 2017
Enhanced Sensitivity of α3β4 Nicotinic Receptors in Enteric Neurons after Long-Term Morphine: Implication for Opioid-Induced Constipation.. 357. 2016
Diisopropylfluorophosphate Impairs the Transport of Membrane-Bound Organelles in Rat Cortical Axons.. 356. 2015
Molecular Interplay between microRNA-34a and Sirtuin1 in Hyperglycemia-Mediated Impaired Angiogenesis in Endothelial Cells: Effects of Metformin.. 356. 2015
Marked Alteration of Rosuvastatin Pharmacokinetics in Healthy Chinese with ABCG2 34G>A and 421C>A Homozygote or Compound Heterozygote.. 354. 2015
Histamine H4-receptors inhibit mast cell renin release in ischemia/reperfusion via protein kinase C ε-dependent aldehyde dehydrogenase type-2 activation.. 349. 2014
A novel and potent inhibitor of dimethylarginine dimethylaminohydrolase: a modulator of cardiovascular nitric oxide.. 348. 2013
Pharmacological distinction between soluble and transmembrane adenylyl cyclases.. 347. 2013
HCN1 channels as targets for anesthetic and nonanesthetic propofol analogs in the amelioration of mechanical and thermal hyperalgesia in a mouse model of neuropathic pain.. 345. 2013
Novel insights into CB1 cannabinoid receptor signaling: a key interaction identified between the extracellular-3 loop and transmembrane helix 2.. 345. 2013
INO-8875, a highly selective A1 adenosine receptor agonist: evaluation of chronotropic, dromotropic, and hemodynamic effects in rats.. 344. 2012
Natriuretic peptide-induced catecholamine release from cardiac sympathetic neurons: inhibition by histamine H3 and H4 receptor activation.. 343. 2012
Aldehyde dehydrogenase type 2 activation by adenosine and histamine inhibits ischemic norepinephrine release in cardiac sympathetic neurons: mediation by protein kinase Cε.. 343. 2012
Histamine 3 receptor activation reduces the expression of neuronal angiotensin II type 1 receptors in the heart.. 340. 2011
Development of a high-affinity inhibitor of the prostaglandin transporter.. 339. 2011
The soluble guanylyl cyclase activator YC-1 increases intracellular cGMP and cAMP via independent mechanisms in INS-1E cells.. 338. 2011
The expression level of ecto-NTP diphosphohydrolase1/CD39 modulates exocytotic and ischemic release of neurotransmitters in a cellular model of sympathetic neurons.. 337. 2011
Interaction between sensory C-fibers and cardiac mast cells in ischemia/reperfusion: activation of a local renin-angiotensin system culminating in severe arrhythmic dysfunction.. 335. 2010
INO-8875, a Highly-Selective A1 Adenosine Receptor Agonist: Evaluation of Chronotropic, Dromotropic and Hemodynamic Effects in Rats. 2010
Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists.. 333. 2010
Cyclophosphamide unmasks an antimetastatic effect of local tumor cryoablation.. 330. 2009
The modulation of synaptic GABA(A) receptors in the thalamus by eszopiclone and zolpidem.. 328. 2008
Deletion of the glutamate receptor 5 subunit of kainate receptors affects the development of morphine tolerance.. 328. 2008
Ligand selectivity of D2 dopamine receptors is modulated by changes in local dynamics produced by sodium binding.. 328. 2008
Inactivation of the maternal fragile X gene results in sensitization of GABAB receptor function in the offspring.. 327. 2008
Cardioprotective effect of histamine H3-receptor activation: pivotal role of G beta gamma-dependent inhibition of voltage-operated Ca2+ channels.. 326. 2008
Sphingosine 1-phosphate inhibits nitric oxide production induced by interleukin-1beta in rat vascular smooth muscle cells.. 325. 2008
Isoflurane is a potent modulator of extrasynaptic GABA(A) receptors in the thalamus.. 324. 2007
Isoflurane inhibits NaChBac, a prokaryotic voltage-gated sodium channel.. 322. 2007
Targeted deletion of ectonucleoside triphosphate diphosphohydrolase 1/CD39 leads to desensitization of pre- and postsynaptic purinergic P2 receptors.. 322. 2007
Design and evaluation of small interfering RNAs that target expression of the N-methyl-D-aspartate receptor NR1 subunit gene in the spinal cord dorsal horn.. 322. 2007
Ciglitazone, a peroxisome proliferator-activated receptor gamma inducer, ameliorates renal preglomerular production and activity of angiotensin II and thromboxane A2 in glycerol-induced acute renal failure.. 322. 2007
Long-term treatment with the apolipoprotein A1 mimetic peptide increases antioxidants and vascular repair in type I diabetic rats.. 322. 2007
Modulation of sympathetic activity by tissue plasminogen activator is independent of plasminogen and urokinase.. 322. 2007
Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects.. 319. 2006
Attenuation of oxygen-induced abnormal lung maturation in rats by retinoic acid: possible role of cytochrome P4501A enzymes.. 317. 2006
Identification of a new class of prostaglandin transporter inhibitors and characterization of their biological effects on prostaglandin E2 transport.. 316. 2005
A nonthiazolidinedione peroxisome proliferator-activated receptor gamma agonist reverses endothelial dysfunction in diabetic (db/db-/-) mice.. 316. 2005
Volatile anesthetic effects on glutamate versus GABA release from isolated rat cortical nerve terminals: 4-aminopyridine-evoked release.. 316. 2005
Volatile anesthetic effects on glutamate versus GABA release from isolated rat cortical nerve terminals: basal release.. 316. 2005
Impairment of hyperpolarization-activated, cyclic nucleotide-gated channel function by the intravenous general anesthetic propofol.. 315. 2005
The nonthiazolidinedione tyrosine-based peroxisome proliferator-activated receptor gamma ligand GW7845 induces apoptosis and limits migration and invasion of rat and human glioma cells.. 313. 2005
Ectonucleoside triphosphate diphosphohydrolase 1/CD39, localized in neurons of human and porcine heart, modulates ATP-induced norepinephrine exocytosis.. 313. 2005
An antisense oligonucleotide to the N-methyl-D-aspartate (NMDA) subunit NMDAR1 attenuates NMDA-induced nociception, hyperalgesia, and morphine tolerance.. 312. 2004
Depression by isoflurane of the action potential and underlying voltage-gated ion currents in isolated rat neurohypophysial nerve terminals.. 312. 2004
Histamine H3-receptor-induced attenuation of norepinephrine exocytosis: a decreased protein kinase a activity mediates a reduction in intracellular calcium.. 312. 2004
Nitric oxide (NO)-releasing naproxen (HCT-3012 [(S)-6-methoxy-alpha-methyl-2-naphthaleneacetic Acid 4-(nitrooxy)butyl ester]) interactions with aspirin in gastric mucosa of arthritic rats reveal a role for aspirin-triggered lipoxin, prostaglandins, and NO in gastric protection.. 311. 2004
Disruption of the Ah receptor gene alters the susceptibility of mice to oxygen-mediated regulation of pulmonary and hepatic cytochromes P4501A expression and exacerbates hyperoxic lung injury.. 310. 2004
2-furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist.. 309. 2004
Cooperation between aspirin-triggered lipoxin and nitric oxide (NO) mediates antiadhesive properties of 2-(Acetyloxy)benzoic acid 3-(nitrooxymethyl)phenyl ester (NCX-4016) (NO-aspirin) on neutrophil-endothelial cell adherence.. 309. 2004
Histamine H1 and H2 receptor gene and protein levels are differentially expressed in the hearts of rodents and humans.. 309. 2004
Simultaneous modeling of abciximab plasma concentrations and ex vivo pharmacodynamics in patients undergoing coronary angioplasty.. 307. 2003
Suppressed prolactin response to dynorphin A1-13 in methadone-maintained versus control subjects.. 306. 2003
Ectonucleotidase in sympathetic nerve endings modulates ATP and norepinephrine exocytosis in myocardial ischemia.. 306. 2003
Selective depression by general anesthetics of glutamate versus GABA release from isolated cortical nerve terminals.. 304. 2003
Proteinase-activated receptor-2 (PAR2): vascular effects of a PAR2-derived activating peptide via a receptor different than PAR2.. 303. 2002
Ischemia promotes renin activation and angiotensin formation in sympathetic nerve terminals isolated from the human heart: contribution to carrier-mediated norepinephrine release.. 302. 2002
EctoNucleotidase in cardiac sympathetic nerve endings modulates ATP-mediated feedback of norepinephrine release.. 300. 2002
Regulation of cyclooxygenase by the heme-heme oxygenase system in microvessel endothelial cells.. 300. 2002
State-dependent block of rabbit vascular smooth muscle delayed rectifier and Kv1.5 channels by inhibitors of cytochrome P450-dependent enzymes.. 298. 2001
Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.. 295. 2000
Opioid receptor imaging with positron emission tomography and [(18)F]cyclofoxy in long-term, methadone-treated former heroin addicts.. 295. 2000
Angiotensin-converting enzyme-independent angiotensin formation in a human model of myocardial ischemia: modulation of norepinephrine release by angiotensin type 1 and angiotensin type 2 receptors.. 294. 2000
Cannabinoids protect cells from oxidative cell death: a receptor-independent mechanism.. 293. 2000
Adenoviral vector-mediated transfer of human heme oxygenase in rats decreases renal heme-dependent arachidonic acid epoxygenase activity.. 293. 2000
LLC-PK(1) cells stably expressing the human norepinephrine transporter: A functional model of carrier-mediated norepinephrine release in protracted myocardial ischemia.. 291. 1999
Differential effects of heme oxygenase isoforms on heme mediation of endothelial intracellular adhesion molecule 1 expression.. 291. 1999
Bradykinin activates a cross-signaling pathway between sensory and adrenergic nerve endings in the heart: a novel mechanism of ischemic norepinephrine release?. 290. 1999
d-Methadone blocks morphine tolerance and N-methyl-D-aspartate-induced hyperalgesia.. 289. 1999
Bradykinin promotes ischemic norepinephrine release in guinea pig and human hearts.. 288. 1999
Large receptor reserve for cannabinoid actions in the central nervous system.. 288. 1999
Dynorphin A1-13 causes elevation of serum levels of prolactin through an opioid receptor mechanism in humans: gender differences and implications for modulation of dopaminergic tone in the treatment of addictions.. 288. 1999
Pharmacokinetics of IgG and IgM anti-ganglioside antibodies in rats and monkeys after intrathecal administration.. 284. 1998
The competitive alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor antagonist LY293558 attenuates and reverses analgesic tolerance to morphine but not to delta or kappa opioids.. 283. 1997
Activation of histamine H3 receptors inhibits carrier-mediated norepinephrine release in a human model of protracted myocardial ischemia.. 283. 1997
d-Methadone is antinociceptive in the rat formalin test.. 283. 1997
Positron emission tomographic analysis of central 5-hydroxytryptamine2 receptor occupancy in healthy volunteers treated with the novel antipsychotic agent, ziprasidone.. 279. 1996
Evaluation of cerebral pharmacokinetics of the novel antidepressant drug, BMS-181101, by positron emission tomography.. 279. 1996
Therapeutic trial of reconstituted human high-density lipoprotein in a canine model of gram-negative septic shock.. 272. 1995
Unmasking of activated histamine H3-receptors in myocardial ischemia: their role as regulators of exocytotic norepinephrine release.. 271. 1994
Kinetic analysis of rat exocrine gland muscarinic receptors in vivo.. 269. 1994
Histamine H3-receptor signaling in the heart: possible involvement of Gi/Go proteins and N-type Ca++ channels.. 269. 1994
Modulation of morphine tolerance by the competitive N-methyl-D-aspartate receptor antagonist LY274614: assessment of opioid receptor changes.. 268. 1994
Nifedipine inhibits the induction of nitric oxide synthase by bacterial lipopolysaccharide.. 265. 1993
Attenuation and reversal of morphine tolerance by the competitive N-methyl-D-aspartate receptor antagonist, LY274614.. 264. 1993
A central nervous system action of nitric oxide in blood pressure regulation.. 262. 1992
Activation of protein kinase A is necessary but not sufficient for ethanol-induced desensitization of cyclic AMP production.. 262. 1992
Mechanism of vascular smooth muscle contraction by sodium fluoride in the isolated aorta of rat and rabbit.. 258. 1991
Tin(Sn+4)-diiododeuteroporphyrin; an in vitro and in vivo inhibitor of heme oxygenase with substantially reduced photoactive properties.. 257. 1991
The hemodynamic effects of S-nitrosocaptopril in anesthetized dogs.. 256. 1991
L-arginine, but not N alpha-benzoyl-L-arginine ethyl ester, is a precursor of endothelium-derived relaxing factor.. 255. 1990
Kinetic analysis of the opiate antagonist cyclofoxy in rat brain: simultaneous infusion of active and inactive enantiomers.. 255. 1990
Electrophysiologic effects of ethanol in human brain xenografts in oculo: antagonism by Ro15-4513.. 254. 1990
Comparative behavioral, neurochemical and pharmacological activities of dihydropyridine calcium channel activating drugs.. 253. 1990
Cardiac dysfunction caused by recombinant human C5A anaphylatoxin: mediation by histamine, adenosine and cyclooxygenase arachidonate metabolites.. 253. 1990
Comparison between the vasoactive actions of endothelin and arginine vasopressin in pithed rats after pretreatment with BAY K 8644, nifedipine or pertussis toxin.. 253. 1990
Pharmacological characterization of morphine-6 beta-glucuronide, a very potent morphine metabolite.. 251. 1989
S-nitrosocaptopril. I. Molecular characterization and effects on the vasculature and on platelets.. 249. 1989
S-nitrosocaptopril. II. Effects on vascular reactivity.. 249. 1989
Morphine-induced tachycardia in fetal lambs: a bell-shaped dose-response curve.. 249. 1989
C3a-induced contraction of guinea pig ileum consists of two components: fast histamine-mediated and slow prostanoid-mediated.. 248. 1989
Adenosine promotes histamine H1-mediated negative chronotropic and inotropic effects on human atrial myocardium.. 247. 1988
Positive inotropic effect of histamine on guinea pig left atrium: H1-receptor-induced stimulation of phosphoinositide turnover.. 247. 1988
Activation of the third complement component (C3) and C3a generation in cardiac anaphylaxis: histamine release and associated inotropic and chronotropic effects.. 246. 1988
Dual action of morphine on fetal breathing movements.. 245. 1988
Negative inotropic effect of platelet-activating factor: association with a decrease in intracellular sodium activity.. 245. 1988
Cerebral metabolic interactions between thyroid state and imipramine in the rat.. 244. 1988
Negative inotropic effect of platelet-activating factor on human myocardium: a pharmacological study.. 243. 1987
Human postjunctional alpha-1 and alpha-2 adrenoceptors: differential distribution in arteries of the limbs.. 241. 1987
Pharmacodynamic supersensitivity and opioid receptor upregulation in the mouse.. 239. 1986
Effect of PGD2 on cardiac contractility: a negative inotropism secondary to coronary vasoconstriction conceals a primary positive inotropic action.. 237. 1986
Depression of contractile responses in rat aorta by spontaneously released endothelium-derived relaxing factor.. 237. 1986
Phosphodiesterase inhibitors induce endothelium-dependent relaxation of rat and rabbit aorta by potentiating the effects of spontaneously released endothelium-derived relaxing factor.. 237. 1986
Pharmacokinetics and pharmacodynamics of subcutaneous naltrexone pellets in the rat.. 237. 1986
Mechanism of tubular uptake on human growth hormone in perfused rat kidneys.. 236. 1986
Pharmacokinetics and pharmacodynamics of subcutaneous morphine pellets in the rat.. 235. 1985
Nimodipine and inhibition of alpha adrenergic activation of the isolated canine saphenous vein.. 234. 1985
Blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation of rabbit aorta by certain ferrous hemoproteins.. 233. 1985
Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta.. 232. 1985
Concurrent measurements of blood flow and transcapillary transport in avian sarcoma virus-induced experimental brain tumors: implications for chemotherapy.. 231. 1984
Adenosine selectively attenuates H2- and beta-mediated cardiac responses to histamine and norepinephrine: an unmasking of H1- and alpha-mediated responses.. 231. 1984
Characterization of postjunctional alpha-1 and alpha-2 adrenoceptors activated by exogenous or nerve-released norepinephrine in the canine saphenous vein.. 230. 1984
Negative inotropic effect of leukotrienes: leukotrienes C4 and D4 inhibit calcium-dependent contractile responses in potassium-depolarized guinea-pig myocardium.. 230. 1984
Differences in d-[3H]lysergic acid diethylamide binding in mouse cortex and hippocampus in vivo and in vitro revealed by radioautography and rapid filtration studies.. 229. 1984
Pharmacological characterization of the postsynaptic alpha adrenoceptors in vascular smooth muscle from canine and rat mesenteric vascular beds.. 229. 1984
Tissue distribution and disposition of tin-protoporphyrin, a potent competitive inhibitor of heme oxygenase.. 228. 1984
Discriminant effects of behaviorally active and inactive analogs of phencyclidine on membrane electrical excitability.. 228. 1984
Reduction of ventricular fibrillation threshold by histamine: resolution into separate H1- and H2-mediated components.. 223. 1982
Antinociceptive activity and toxicity of meperidine and normeperidine in mice.. 223. 1982
Nicotinic-catecholaminergic interactions in rat brain: evidence for cholinergic nicotinic and muscarinic interactions with hypothalamic epinephrine.. 221. 1982
Leukotrienes C4, D4 and E4: effects on human and guinea-pig cardiac preparations in vitro.. 221. 1982
Pharmacodynamics of subcutaneously administered diacetylmorphine, 6-acetylmorphine and morphine in mice.. 218. 1981
Antiarrhythmic effect of manganese chloride in infarcted dogs with observations on the dose-related response of heart rate and ventricular pressure.. 218. 1981
Methadone: radioimmunoassay and pharmacokinetics in the rat.. 217. 1981
Thromboxane and prostacyclin release during cardiac immediate hypersensitivity reactions in vitro.. 217. 1981
Tyrosine hydroxylase: studies on the phosphorylation of a purified preparation of the brain enzyme by the cyclic AMP-dependent protein kinase.. 216. 1981
The cardiac pharmacology of tiotidine (LCL 125, 211): a new histamine H2-receptor antagonist.. 214. 1980
The cardiac effects of prostaglandins and their modification by the prostaglandin antagonist N-0164.. 214. 1980
Renal tubular secretion of meperidine by the fetal lamb.. 213. 1980
Localization and quantitation of lithium in rat tissue following intraperitoneal injections of lithium chloride. II. Brain.. 212. 1980
Urinary excretion of meperidine by the fetal lamb.. 209. 1979
Actions at neuromuscular and esteratic cholinoceptive sites of some phenylene diacryloyl bis-cholinium esters.. 208. 1979
Histamine-induced negative inotropism: mediation by H1-receptors.. 206. 1978
Meperidine pharmacokinetics in the maternal-fetal unit.. 206. 1978
Modification of the effects of histamine and norepinephrine on the sinoatrial node pacemaker by potassium and calcium.. 204. 1978
Tryptoline inhibition of serotonin uptake in rat forebrain homogenates.. 198. 1976
Monoamine oxidase inhibition and the induction of ponto-geniculo-occipital wave activity by reserpine in the cat.. 197. 1976
Dopamine synthesis in rat brain striatal synaptosomes. I. Correlations between veratridine-induced synthesis stimulation and endogenous dopamine release.. 197. 1976
Dopamine synthesis in rat brain striatal synaptosomes. II. Dibutyryl cyclic adenosine 3':5'-monophosphoric acid and 6-methyltetrahydropterine-induced synthesis increases without an increase in endogenous dopamine release.. 197. 1976
Intrathecal chemotherapy: brain tissue profiles after ventriculocisternal perfusion.. 195. 1975
Intestinal smooth muscle contraction and the effects of cadmium and A23187.. 194. 1975
Cardiac histamine-ouabain interaction: potentiation by ouabain of the arrhythmogenic effects of histamine.. 192. 1975
Brain norepinephrine metabolism and shock-induced fighting behavior in rats: differential effects of shock and fighting on the neurochemical response to a common footshock stimulus.. 190. 1974
A comparison of psychotomimetic drug effects on rat brain norepinephrine metabolism.. 189. 1974
Differences in inducibility of cutaneous and hepatic drug metabolizing enzymes and cytochrome P-450 by polychlorinated biphenyls and 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT).. 188. 1974
Drug stimulation of -aminolevulinic acid synthetase and cytochrome P-450 in vivo in chick embryo liver.. 185. 1973
Effects of exogenous and immunologically released histamine on the isolated heart: a quantitative comparison.. 182. 1972
The tubular transport and metabolism of morphine-N-methyl-C14 by the chicken kidney.. 157. 1967
Effects of melatonin and related compounds on the release of glycerol from rat adipose tissue in vitro.. 152. 1966
STRESS-INDUCED RELEASE OF BRAIN NOREPINEPHRINE AND ITS INHIBITION BY DRUGS.. 143. 1964
The synthesis and estimation of N-C14-methyl labeled levorphanol and its biological disposition in the monkey, dog and rat.. 124. 1958
S1P Signaling and De Novo Biosynthesis in Blood Pressure Homeostasis. 2016
Functional selectivity and classical concepts of quantitative pharmacology. 2006
Ligand discovery using small molecule microarrays. 2004
Pharmacogenetic considerations in diseases of cardiac ion channels. 2003
Metabolic control of excessive extracellular nucleotide accumulation by CD39/ecto-nucleotidase-1: implications for ischemic vascular diseases. 2003
Histamine H(3)-receptors: a new frontier in myocardial ischemia. 2000

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