Clinical pharmacology and therapeutics

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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for UGT1A1 and Atazanavir Prescribing. 2015
Treatment of urinary incontinence with anticholinergics in patients taking cholinesterase inhibitors for dementia. 2004
Treatment of opioid-induced constipation with oral naloxone: a pilot study. 1992
The absence of significant biliary excretion of antipyrine or its metabolites in humans. 1987
Angiotensin-Converting Enzyme Inhibitors Used Concomitantly with Insulin Secretagogues and the Risk of Serious Hypoglycemia.. 111. 2021
Comparative Safety of Dipeptidyl Peptidase-4 Inhibitors and Sudden Cardiac Arrest and Ventricular Arrhythmia: Population-Based Cohort Studies.. 111. 2021
Pharmacokinetics and Drug-Drug Interactions of Isoniazid and Efavirenz in Pregnant Women Living With HIV in High TB Incidence Settings: Importance of Genotyping.. 109. 2020
Response to Inhibition of Receptor-Interacting Protein Kinase 1 (RIPK1) in Active Plaque Psoriasis: A Randomized Placebo-Controlled Study.. 108. 2020
Severe hypoglycemia in users of sulfonylurea antidiabetic agents and antihyperlipidemics.. 99. 2016
Design and anticipated outcomes of the eMERGE-PGx project: a multicenter pilot for preemptive pharmacogenomics in electronic health record systems.. 96. 2014
Equivalent dynamic human brain NK1-receptor occupancy following single-dose i.v. fosaprepitant vs. oral aprepitant as assessed by PET imaging.. 92. 2012
Integration of genetic, clinical, and INR data to refine warfarin dosing.. 87. 2010
A dosing/cross-development study of the multikinase inhibitor sorafenib in patients with pulmonary arterial hypertension.. 87. 2009
A population pharmacokinetic and pharmacodynamic evaluation of pralatrexate in patients with relapsed or refractory non-Hodgkin's or Hodgkin's lymphoma.. 86. 2009
The Reference Image Database to Evaluate Response to therapy in lung cancer (RIDER) project: a resource for the development of change-analysis software.. 84. 2008
Germline polymorphisms in EGFR and survival in patients with lung cancer receiving gefitinib.. 83. 2007
Over-the-counter statins and cardiovascular disease prevention: perspectives, challenges, and opportunities.. 78. 2005
Pharmacokinetic interactions between indinavir plus ritonavir and calcium channel blockers.. 78. 2005
Abciximab pharmacodynamic model with neural networks used to integrate sources of patient variability.. 75. 2004
Effects of three fluoroquinolones on QT interval in healthy adults after single doses.. 73. 2003
Pharmacodynamics of abciximab during angioplasty: comparison to healthy subjects.. 71. 2002
Pharmacokinetics of betamethasone in twin and singleton pregnancy.. 71. 2002
Down-regulation of the pharmacokinetic-pharmacodynamic response to interleukin-12 during long-term administration to patients with renal cell carcinoma and evaluation of the mechanism of this "adaptive response" in mice.. 65. 1999
Drug-related hospitalization at a tertiary teaching center in Lebanon: incidence, associations, and relation to self-medicating behavior.. 64. 1998
Comparative effects of omeprazole on xenobiotic metabolizing enzymes in the rat and human.. 58. 1995
The metabolite morphine-6-glucuronide contributes to the analgesia produced by morphine infusion in patients with pain and normal renal function.. 51. 1992
Effects of protein and carbohydrate content of diet on drug conjugation.. 50. 1991
Transdermal versus subcutaneous leuprolide: a comparison of acute pharmacodynamic effect.. 48. 1990
Dopamine clearance in critically ill infants and children: effect of age and organ system dysfunction.. 48. 1990
Pharmacokinetic-pharmacodynamic relationships of methadone infusions in patients with cancer pain.. 47. 1990
Reversal of a calcium-mediated vasoconstrictor component in patients with congestive heart failure.. 46. 1989
Increased renal tubular cell excretion by patients receiving chronic therapy with gold and with nonsteroidal anti-inflammatory drugs.. 46. 1989
Successful transdermal administration of therapeutic doses of a polypeptide to normal human volunteers.. 44. 1988
Hydromorphone levels and pain control in patients with severe chronic pain.. 44. 1988
Sublingual absorption of selected opioid analgesics.. 44. 1988
Ribavirin pharmacodynamics in high-risk patients for acquired immunodeficiency syndrome.. 42. 1987
Pharmacokinetics and pharmacodynamics of methadone in patients with chronic pain.. 41. 1987
Disposition of tin-protoporphyrin and suppression of hyperbilirubinemia in humans.. 39. 1986
Metoclopramide decreases renal plasma flow.. 39. 1986
Epidural and intrathecal opiates: cerebrospinal fluid and plasma profiles in patients with chronic cancer pain.. 38. 1985
Antihypertensive and cardiovascular effects of nitrendipine: a controlled study vs. placebo.. 38. 1985
Plasma 10-hydroxynortriptyline in elderly depressed patients.. 35. 1984
Effect of brussels sprouts and cabbage on drug conjugation.. 35. 1984
Acetaminophen metabolism in subjects fed charcoal-broiled beef.. 34. 1983
Cigarette smoking and chlorpromazine disposition and actions.. 31. 1982
Propoxyphene and norpropoxyphene kinetics after single and repeated doses of propoxyphene.. 31. 1982
Determinants of response to anorexiants.. 30. 1981
Intraindividual variation in drug disposition.. 26. 1979
Nutrition and oxidative drug metabolism in man: relative influence of dietary lipids, carbohydrate, and protein.. 26. 1979
Stimulatory effect of brussels sprouts and cabbage on human drug metabolism.. 25. 1979
Effect of charcoal-broiled beef on antipyrine and theophylline metabolism.. 23. 1978
Oxidative drug metabolism and inducibility by phenobarbital in sickle cell anemia.. 22. 1977
The inducing properties of polychlorinated biphenyls on hepatic monooxygenases.. 22. 1977
Alterations in drug metabolism in workers exposed to polychlorinated biphenyls.. 22. 1977
Enhanced phenacetin metabolism in human subjects fed charcoal-broiled beef.. 20. 1976
Influence of dietary protein and carbohydrate on antipyrine and theophylline metabolism in man.. 20. 1976
Effects of acetylmethadol on plasma testosterone.. 19. 1976
Lead intoxication: effects on cytochrome P-450-mediated hepatic oxidations.. 19. 1976
Studies in porphyria. V. Drug oxidation rates in hereditary hepatic porphyria.. 19. 1976
Disposition of acetylmethadol in relation to pharmacologic action.. 18. 1975
Drug metabolism in normal children, lead-poisoned children, and normal adults.. 17. 1975
Treatment of malignant melanoma with methyl CCNU.. 15. 1974
Disposition of propoxyphene and norpropoxyphene in man after a single oral dose.. 15. 1974
Inducibility of benzo( )pyrene hydroxylase in human skin by polycylic hydrocarbons.. 14. 1973
Disposition of methadone in man after a single oral dose.. 13. 1972
The levels of methadone in the plasma in methadone maintenance.. 13. 1972
Phenylalanine tolerance tests in patients receiving chloramphenicol.. 9. 1968
THE PHYSIOLOGIC DISPOSITION OF 5-FLUOROURACIL AND 5-FLUORO-2'-DEOXYURIDINE IN MAN.. 5. 1964
Experimental perfusion system utilizing the rabbit Vx-2 carcinoma. III. Correlative studies of in vitro sterilization of Vx-2 cells with results of perfusions in rabbits and in patients.. 3. 1962
Biotechnology and therapeutics. 1993
Emerging Innovative Therapeutic Approaches Leveraging Cyclin-Dependent Kinase Inhibitors to Treat Advanced Breast Cancer. 2018
Optimizing treatment for patients with anaplastic lymphoma kinase-positive lung cancer. 2017
Pharmacoepidemiologic Methods for Studying the Health Effects of Drug-Drug Interactions. 2015
New drug targets for the treatment of obesity. 2011
Biomarkers in early cancer drug development: limited utility. 2009
New targets for obesity pharmacotherapy. 2007
Biotechnology and therapeutics: expensive treatments and limited resources. A view from the hospital. 1992
Nutrition and chemical biotransformations in man. 1977
Regulation of cytochrome P-450-dependent microsomal drug-metabolizing enzymes by nickel, cobalt, and iron. 1977

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Clinical pharmacology and therapeutics Journal

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