National Cancer Institute Funding Organization

Research

awards grant

• "DNMT and TET1 reprogramming as a targetable mechanism of resistance in advanced prostate cancer"
• (PQ 6) New Models of KSHV Oncogenesis and KS Immune Environment
• (PQ 6) New Models of KSHV Oncogenesis and KS Immune Environment
• (PQ1) Adaptive immune and microbial mechanisms regulating Lynch syndrome penetrance
• 3D co-culture system to characterize and target leukemia stem cells
• A multiplexed approach to improve tumoral targeting and chemotherapeutic treatment
• A novel, short isoform of the +TIP microtubule (MT) binding protein CLIP170 confers taxane resistance by obstructing the MT pore.
• Active Contrast Encoding MRI for Breast Cancer
• An urinary drug disposing approach for treatment of bladder Cancer
• B cell determinants of EBV latency
• Behavioral and Psychosocial Effects on Study Outcomes in End-Stage Cancer Treatment (BEST End-Stage Cancer Study)
• CAP-IT Center for LNP RNA Immunoprevention
• CAR T Cells for Advanced Thyroid Cancer
• Cancer Cell Intrinsic Interferon-I pathway Activation by Fractionated Radiation
• Cancer Pharmacology
• Cell-of-Origin Footprints of Passenger Mutations in Human Lung Cancer
• Characterization of Premalignant Fields in a Murine Model of Head and Neck and Esophageal Cancers
• Characterizing stem cell-like B cell subpopulations and dissecting their role in tumorigenesis
• Cholesterol Metabolism in Mesenchymal Colorectal Cancer
• Chromatin''s Role in Repair of Radiation-induced Damage
• Collaborative genomic alterations and transcriptional control in prostate cancer
• Combination Therapies Targeting Insulin Signaling in Endometrial Cancer
• Computational Methods for Identifying Non-Coding Cancer Drivers
• Contributions of tumor molecular subtypes to prostate cancer racial disparities
• Coordinate Regulation of Oncogenic Signaling Pathways in SPOP Mutant Prostate Cancer
• Copper-Mediated Metabolic Reprogramming And ECM Alterations In TNBC Metastasis
• Customized nanofibers with preferential lung-targeting properties for treating metastatic pulmonary tumors
• DOTA-based pre-targeting of alpha emitters
• Deep learning-based approach to identify non-coding cancer drivers that alter chromatin conformation
• Defining Epidrivers of CLL Evolution in Response to Targeted Therapy
• Defining Molecular Determinants of Lineage Plasticity as a Mechanism of Treatment Resistance in Prostate Cancer
• Defining the epigenetic landscape and therapeutic vulnerabilities of Richter''s syndrome in CRISPR-based mouse models
• Delirium in Children Undergoing Hematopoietic Stem Cell Transplants
• Differential role of different NAD+ kinase Isoforms in melanoma metastasis
• Diffusion MRI of Treatment Response for De-escalation of Radiation Therapy
• Disruption of epigenetic regulation of enhancers in the germinal center reaction drives clonal evolution in Follicular Lymphoma
• Dissecting the impact of tumor-intrinsic chromosomal instability on the cancer ecosystem
• Dissecting the in vivo stromal metabolic and inflammatory crosstalk in colorectal cancer
• Dissecting the interplay between immunoglobulin G and the gut microbiome in cancer progression and metastasis
• Dynamics of Immune Response in Irradiated Rectal Cancer
• ER stress-driven IRE1a-XBP1 signaling in lung cancer
• Elucidating the Role of MALAT1 Somatic Driver Mutations in Colorectal Cancer
• Evaluation of Transperineal Biopsy under Local Anesthesia, a Novel approach to Decrease Post-Biopsy Infections and Improve Cancer Detection
• Expanding the GoT toolkit to link single-cell clonal genotypes with protein, transcriptomic, epigenomic and spatial phenotypes
• Exploiting tumor metabolism to optimize T cell therapy
• G3BP1 Suppresses SPOP Ubiquitin Ligase to Promote Prostate Tumorigenesis
• Genome-wide mutational integration for ultra-sensitive plasma tumor burden monitoring in immunotherapy
• Gradient-Echo Spectroscopic Imaging Study of Saturated Fat and Breast Cancer
• Harnessing oral acetate supplementation to enhance anti-tumor immunity
• Harnessing the CRL4 Ubiquitin Ligase for Antagonizing Colorectal Carcinogenesis
• Image-guided Trp-IDO/TDO-Kyn-AHR pathway inhibition, combined with immunotherapy
• Immunometabolic Programs Controlled by ER Stress in Cancer
• Immunoregulatory role of lung-resident club cell factors in lung cancer
• Immunosuppressive Programs Driven by IRE1 signaling in ovarian cancer
• In Vivo Base Editing for Precision Oncology Models
• Inflammation-induced cellular plasticity in pancreatic homeostasis and tumorigenesis
• Innate lymphoid cell regulation of the host-microbiota interactions in cancer
• Intercepting progression from pre-invasive to invasive lung adenocarcinoma
• Intercepting progression from pre-invasive to invasive lung adenocarcinoma
• Interferon regulation by NBR1-driven chaperone-mediated autophagy in stellate cells in liver cancer
• Interrogating the role of mutant KRAS allelic imbalance and co-mutated genes in targeted therapy response of NSCLC
• Investigating the non-cell autonomous immune effects of mutant p53 in pancreatic cancer
• Investigating the role of the microbiota in enhancing memory T cell function during caloric restriction to promote melanoma control
• Mechanism-Based Targeting of Mantle Cell Lymphoma
• Mechanisms and functions of N6-methyladenosine (m6A) in cancer
• Mitogenic and Oncogenic Regulation of ERK/RSK Signaling
• Mitogenic and Oncogenic Regulation of ERK/RSK Signaling
• Modeling Hepatoblastoma using pluripotent stem cell derived hepatocyte-like cells
• Molecular Mechanisms of Fructose-induced Colorectal Cancer Cell Survival
• Molecular and Translational Oncology Research
• Molecular mechanisms driving mesenchymal colorectal cancer
• Neoantigen Vaccination for Lynch Syndrome Immunoprevention
• Next-Gen Oncopathology Program
• Novel Mouse Models for Quantitative Understanding of Baseline and Therapy-Driven Evolution of Prostate Cancer Metastasis
• Novel Pathways in the Control of Lineage Plasticity in Neuroendocrine Prostate Cancer
• Opioid Treatment of Pain in People with Cancer: Intended and unintended consequences of state policies addressing opioid prescribing
• Optimizing the Delivery of Diabetes Management During Breast Cancer Care
• PSMA/MR-guided Stereotactic Body Radiotherapy for High Risk Prostate Cancer
• Partnership for Prevention of HPV-Associated Cancers in People Living with HIV: Brazil, Mexico, and Puerto Rico
• Partnership for advancing cervical cancer prevention in women living with HIV (CASCADE - Research Hub)
• Pelvic fascia spARing radical prostatectomy TrIAL (PARTIAL)
• Pre-malignant mutation landscape and risk factors for progression to hematologic cancers
• Prediagnostic Exposures, Germline Genetics, And Triple Negative Breast Cancer Mutational And Immune Profiles
• Prediction of interval breast cancer risk using genetic variants
• Preventing follicular lymphoma progression and transformation through precision therapy
• Probing cytosolic nucleic acid sensing pathways in cancer
• Progression, response, and resistance of RSPO fusion colorectal cancer
• Propionate metabolism and cancer
• Rational design of drug combinations to target chemotherapy resistance in high-grade serous ovarian cancer via metabolomic profiling of patient-derived organoids
• Receptor for hyaluronan-mediated motility isoform B (RHAMM B) in Pancreatic Cancer Metastasis
• Regulation of the Selenocysteine Stress Response in Cancer Metastasis
• Regulatory Crosstalk Between Human Endogenous Retroviruses, HIV, and EBV, in Lymphoma
• Role of BCL10 somatic mutations in lymphomagenesis and response to BCR-targeted therapies
• Role of Chromatin Remodeling Complex BAF in Immunity and Lymphoma
• Role of FAP-positive cells in immune response to irradiated glioblastoma
• Role of chromatin remodeling complex BAF in immunity and lymphoma
• Role of novel onco-histone mutations in B-cell malignancies
• Role of the smooth muscle layer in bladder cancer biology and progression: a systems and experimental approach
• Role of the stromal microenvironment in B-cell lymphoma progression and immune escape
• Shapeshifters in Cancer: Defining the Fundamental Forces of Leukemia Evolution
• Studies of the initiation and progression of small cell lung cancer using cells derived by differentiation from human pluripotent stem cells
• Systemic regulation of metastasis
• TORFP 2018-E12: Frameshift Peptide Vaccine for the Prevention of Lynch Syndrome-associated Gastrointestinal Cancer
• Targeting Epigenetic Circuits in B-Cell Lymphomas
• Targeting Latency Switch in EBV+ Lymphomas
• The CANcer Cachexia Action Network (CANCAN): a Multidisciplinary Virtual Institute with the Mission to Cure Cancer Cachexia
• The DARC side of Breast Cancer Disparities - African Ancestry and Cancer- Related Immune Response
• The Joint WCM-NYGC Center for Functional and Clinical Interpretation of Tumor Profiles
• The joint WCM-NYGC Center for Functional and Clinical Interpretation of Tumor Profiles
• The role of NAGK cysteine deprotonation in nutrient stress and cancer progression
• Therapeutic Targeting of SIRT3 for Aggressive and Refractory Lymphomas
• To study the EMT contributions in tumor metastasis and chemoresistance by using lineage tracing models
• Transcriptional Determinants of L-Asparaginase Response in Leukemia
• Tumor selective inhibition of the WNT pathway
• UBR5''s Mechanisms of Action in Tumorigenesis and Immunoregulation
• Weill Cornell Medicine (WCM) SPORE in Prostate Cancer