Meyer Cancer Center Academic Department

Research

administers grant

• A multi-omics, single-cell toolkit to study disrupted hematopoietic differentiation in clonal hematopoiesis
• BPTF-mediated gene regulation in prostate cancer
• BWF 2015 Career Award for Medical Scientists
• Biology of R-Spondin-Induced Sensitization to Asparaginase in Colorectal Cancer
• Bridging predictive models and precision immunotherapies
• Cell-of-Origin Footprints of Passenger Mutations in Human Lung Cancer
• Center for Integrated Cellular Analysis
• Characterization of mpMRI Features Associated with Persistence and Recurrence of Prostate Cancer After Partial Gland Ablation
• Characterizing stem cell-like B cell subpopulations and dissecting their role in tumorigenesis
• Charting the differentiation topology of SF3B1 mutated clonal hematopoiesis (CH) and myelodysplastic syndromes (MDS) via a multi-omics single-cell toolkit
• Clinical identification and targeting of non-neuroendocrine lineage plasticity in castration-resistant prostate cancer
• Collaborative genomic alterations and transcriptional control in prostate cancer
• Computational Methods for Identifying Non-Coding Cancer Drivers
• Coordinate Regulation of Oncogenic Signaling Pathways in SPOP Mutant Prostate Cancer
• DNA Vaccines Against Cancer and Infectious Organisms
• Deciphering differentiation hierarchies, heritability and plasticity in gliomas via single-cell multi-omics.
• Deciphering heritability, plasticity and differentiation trajectories in gliomas via single-cell multi-omics
• Deciphering the fitness determinants of clonal mosaicism
• Deep learning-based approach to identify non-coding cancer drivers that alter chromatin conformation
• Defining Epidrivers of CLL Evolution in Response to Targeted Therapy
• Defining Evolutionary Trajectories Driving Prostate Cancer Metastases
• Defining the Genetic Determinants of Response to B-Catenin Blockade in CRC
• Defining the evolutionary mechanisms of IDH-mutant glioma progression through single-cell multi-omics innovation
• Defining the impact of Kras mutational heterogeneity on the tumor microenvironment in pancreatic cancer
• Defining the role of DNA methylation modifier mutations in reshaping blood differentiation topology
• Determining Metastatic Drivers of Pten/p53-Loss-Driven Prostate Cancer Using Evolving DNA Barcodes
• Determining and Targeting Evolutionary Trajectories Driving Bladder Cancer
• Developing Novel Therapeutic Approaches for Classical and Variant Hairy Cell Leukemia (Core 2)
• Developing Novel Therapeutic Approaches for Classical and Variant Hairy Cell Leukemia (Project 1)
• Differential role of different NAD+ kinase Isoforms in melanoma metastasis
• Discovery of diabetes-relevant β cell enhancers through 4D enhancer mapping, integrative analysis, and large-scale CRISPRi perturbation screens
• Dissecting mechanisms of epigenetic inheritance of pluripotent stem cell identity
• Epigenetic mechanisms of transcriptional activation of a novel oncogenic ALK variant in cancer
• Establishing the role of Methylmalonic Acid in KRAS-mutated Lung Adenocarcinoma
• Evaluation of Transperineal Biopsy under Local Anesthesia, a Novel approach to Decrease Post-Biopsy Infections and Improve Cancer Detection
• Expanding the GoT toolkit to link single-cell clonal genotypes with protein, transcriptomic, epigenomic and spatial phenotypes
• Experimental And Preclinical Modeling Of NUP98-Rearranged Acute Leukemia
• Functional Dissection of Regulatory Myeloid Cells in Microbe-Immune Crosstalk in Skin
• Gene regulatory networks in early lung epithelial cell fate decisions
• Genetic Reprogramming of the Solid Tumor Immune Microenvironment
• Genome-wide mutational integration for ultra-sensitive plasma tumor burden monitoring in immunotherapy
• Group 2 Innate Lymphoid Cell Regulation of Pancreatic Cancer Immunity
• Identifying acquired vulnerabilities driven by lineage plasticity and drug resistance in CRC
• Image-guided Trp-IDO/TDO-Kyn-AHR pathway inhibition, combined with immunotherapy
• In Vivo Base Editing for Precision Oncology Models
• Interrogating unique DC adaptations to tissue to promote barrier immunity and tolerance
• Ludwig Collaborative Laboratory
• Lymphoma Scientific Research Mentoring Program (LSRMP)
• MSK Immuno-Oncology for the Translational Researcher Short Course
• Mark Foundation Emerging Leader Award
• Mechanism-Based Approach for Combination Therapies with Immune Modulation for Management of Patients with Urothelial Cancers of the Upper Urinary Tract
• Mechanisms of enhancer regulation in leukemia
• Mitogenic and Oncogenic Regulation of ERK/RSK Signaling
• Mitogenic and Oncogenic Regulation of ERK/RSK Signaling
• Mosaic: post-zygotic mutations in vascular and lymphatic developmental disorders.
• Multiomics of pluripotent stem cell derived gastruloids
• Mutations in epigenetic modifiers lead to alternative splicing in clonal hematopoiesis
• Nonclinical Research Agreement - BMS
• Novel Mouse Models for Quantitative Understanding of Baseline and Therapy-Driven Evolution of Prostate Cancer Metastasis
• Organizational principles and functional role of 3D enhancer hubs in cell fate decisions
• Pelvic fascia spARing radical prostatectomy TrIAL (PARTIAL)
• Peripheral immune surveillance and long-lived barrier immunity through T cell DC cross-talk
• Progression, response, and resistance of RSPO fusion colorectal cancer
• Propionate metabolism and cancer
• Prostate Cancer Comparative Outcomes of New Conceptual Paradigms for Treatment (PC CONCEPT)
• Proteogenomic studies to understand mechanisms and drivers of resistance to immunotherapies
• Randomized Trial Comparing Transperineal vs. Transrectal MRI-targeted Prostate Biopsy
• Research Scholar Grants
• Revolution Medicines, Inc. Biopharma
• Shapeshifters in Cancer: Defining the Fundamental Forces of Leukemia Evolution
• Signal Transduction to P70 S6 Kinase 1
• Single-cell multi-omics to link clonal mosaicism (CM) genotypes with chromatin, epigenomic, transcriptomic and protein phenotypes
• Sponsored Research Agreement - Merghoub Lab
• State Selective Lethality: Exploiting a Previously Unrecognized Therapeutic Vulnerability in Glioblastoma
• Structure, Function, and Dynamics of Macro-molecular Complexes that Execute and Regulate Genome Function
• Studies of the initiation and progression of small cell lung cancer using cells derived by differentiation from human pluripotent stem cells
• Studying the role of macrophages and gluconeogenesis in the regulation of Mycobacterium tuberculosis persistence in a mouse model of latency
• Targeting BRCA1-mutant breast cancer cells with folate and vitamin C
• The role of DNA methylation modifiers in shaping the hematopoietic differentiation topology
• The role of NAGK cysteine deprotonation in nutrient stress and cancer progression
• Tumor selective inhibition of the WNT pathway
• Turning insulin addiction and KRAS/BRCA2 co-mutations into vulnerabilities for pancreatic cancer treatment
• Understanding and characterizing the role of splicing factor mutations in progression of myeloproliferative neoplasms to accelerated and blast phase
• Understanding tumor-immune interactions in cancer initiation and progression (Long-Term Fellowship 2022)
• tRNA wobble modifications as drivers of the adaptive proteome in stress resistance and metastasis