Late cytomegalovirus pneumonia in adult allogeneic blood and marrow transplant recipients. Academic Article uri icon

Overview

abstract

  • To assess the impact of antiviral prophylaxis during the first 3 months after transplantation on the frequency, timing, and outcome of cytomegalovirus (CMV) pneumonia during the first year, 541 adult allogeneic blood and marrow transplant recipients were evaluated. Thirty-four patients (6.3%) developed 35 episodes of CMV pneumonia at a mean of 188 days after transplantation, with an associated mortality rate of 76%. Twenty-six episodes (74%) occurred late (after day 100). Of the patients with late CMV pneumonia almost all (92%) had chronic graft vs. host disease or had received T cell-depleted transplants. Fourteen late CMV pneumonias (54%) were associated with serious concurrent infections, and 100% of these episodes were fatal. In conclusion, although the frequency of CMV pneumonia in the early posttransplantation period may be substantially reduced by prophylaxis, CMV continues to be a major cause of morbidity and mortality in the late period. Some subsets of patients need more prolonged surveillance and prophylaxis and/or preemptive therapy.

publication date

  • March 1, 1999

Research

keywords

  • Antiviral Agents
  • Bone Marrow Transplantation
  • Cytomegalovirus Infections
  • Hematopoietic Stem Cell Transplantation
  • Pneumonia, Viral

Identity

Scopus Document Identifier

  • 0033013624

Digital Object Identifier (DOI)

  • 10.1086/515146

PubMed ID

  • 10194088

Additional Document Info

volume

  • 28

issue

  • 3