Molecular genetics of acute promyelocytic leukemia. Review uri icon

Overview

abstract

  • The remarkable success of retinoic acid in the treatment of acute promyelocytic leukemias and the subsequent discovery that mutant forms of a retinoid acid receptor (RARalpha) are invariably associated with this disease has generated considerable interest among both clinicians and basic scientists. Studies both in cell culture and in transgenic animals suggest that mutant RARs interfere with normal retinoid-mediated transactivation and granulocytic differentiation. More recently, a pivotal link between transcriptional silencing, the oncogenic functions of RAR mutants, and hormonal responses in APL patients has been established. These studies have greatly advanced our understanding of the molecular changes involved in leukemogenesis, have helped to reveal new aspects of cellular differentiation, and might lead to improved treatment strategies for human leukemias.

publication date

  • May 1, 1999

Research

keywords

  • Leukemia, Promyelocytic, Acute

Identity

Scopus Document Identifier

  • 0032949304

Digital Object Identifier (DOI)

  • 10.1016/s0168-9525(99)01710-2

PubMed ID

  • 10322484

Additional Document Info

volume

  • 15

issue

  • 5