Protective role of heme oxygenase-1 in oxidative stress-induced neuronal injury. Academic Article uri icon

Overview

abstract

  • Heme oxygenase-1 (HO-1) is a stress protein induced in response to a variety of oxidative challenges. After treatment of the hybrid septal cells SN 56 with beta-amyloid peptide (beta-AP1-40) or hydrogen peroxide (H2O2), we detected high levels of reactive oxygen species, accompanied by a significant elevation in HO-1 expression. Levels of HO-1 increased and then decreased following cell loss. Pretreatment of SN 56 cells with HO-1 antisense oligonucleotides dramatically decreased the immunoreactivity of HO-1 and significantly enhanced the cytotoxicity of beta-AP1-40 and H2O2. In contrast, pretreatment with hemin, an HO-1 inducer, increased the expression of HO-1 and decreased the beta-AP1-40- and H2O2-induced cytotoxicity. These findings support the importance of HO-1 in protecting neurons against oxidative stress-induced injury.

publication date

  • June 15, 1999

Research

keywords

  • Heme Oxygenase (Decyclizing)
  • Neurons
  • Oxidative Stress

Identity

Scopus Document Identifier

  • 0033564616

Digital Object Identifier (DOI)

  • 10.1002/(SICI)1097-4547(19990615)56:6<652::AID-JNR11>3.0.CO;2-5

PubMed ID

  • 10374820

Additional Document Info

volume

  • 56

issue

  • 6