Role of p27 in prostate carcinogenesis. Review uri icon

Overview

abstract

  • The cyclin dependent kinase inhibitor p27 binds to and inhibits preferentially S-phase kinases thereby halting cell cycle progression. Loss of p27 expression has been shown to be associated with aggressive behavior in a variety of human epithelial tumors including prostate cancer. In this review, the role of p27 in cell cycle progression as well as its regulation by the ubiquitin-proteasome pathway are discussed. The experimental evidence pointing to the role of p27 as a tumor suppressor gene is outlined. The data generated to date on the prognostic significance of loss of p27 protein expression in human prostate cancers are summarized. Finally, the implications of the changes in p27 expression which occur as a result of androgen ablation in normal and neoplastic prostate are discussed.

publication date

  • January 1, 1998

Research

keywords

  • Cell Cycle Proteins
  • Enzyme Inhibitors
  • Microtubule-Associated Proteins
  • Prostate
  • Prostatic Neoplasms
  • Tumor Suppressor Proteins

Identity

Scopus Document Identifier

  • 0001746766

Digital Object Identifier (DOI)

  • 10.1023/a:1006133620914

PubMed ID

  • 10453277

Additional Document Info

volume

  • 17

issue

  • 4