Mononuclear cell adherence to cultured endothelium is enhanced by hypertension and insulin resistance in healthy nondiabetic volunteers. Academic Article uri icon

Overview

abstract

  • BACKGROUND: This study was initiated to compare the adherence to cultured endothelial cells of mononuclear cells isolated from normotensive and hypertensive individuals. METHODS AND RESULTS: Mononuclear cell binding to endothelium was greater in patients with hypertension (32+/-1 versus 25+/-2; P<0.001) than in normal volunteers. There was a significant relationship (r=0.42, P<0. 01) between mononuclear cell binding and mean arterial pressure, independent of differences in age, sex, and body mass index. A significant relationship also existed between insulin resistance (estimated by the steady-state plasma glucose concentration during the insulin suppression test) and mononuclear cell binding in both the normotensive (r=0.86, P<0.001) and hypertensive (r=0.74, P<0. 001) groups. Furthermore, multiple regression analysis demonstrated an independent relationship (P<0.001) between mononuclear cell binding and both steady-state plasma glucose and hypertensive status. CONCLUSIONS: These results indicate that both hypertension and insulin resistance lead to changes in mononuclear cells that increase their adherence to cultured endothelial cells.

publication date

  • August 31, 1999

Research

keywords

  • Endothelium, Vascular
  • Hypertension
  • Insulin Resistance
  • Leukocytes, Mononuclear

Identity

Scopus Document Identifier

  • 0033621020

Digital Object Identifier (DOI)

  • 10.1161/01.cir.100.9.940

PubMed ID

  • 10468524

Additional Document Info

volume

  • 100

issue

  • 9