The relationship of serum androgens and ovulatory status to blood pressure in reproductive-age women. Academic Article uri icon

Overview

abstract

  • The objective of this cross-sectional study was to determine the relationship between hyperandrogenemia and blood pressure in women with menstrual irregularities seen at an endocrinology clinic. Women with serum testosterone levels (T) > or = 30 ng/dL were more likely to have general obesity (odds ratio [OR] = 6.8, 95% confidence intervals [CI] = 2.2-27.2) and central obesity (OR = 14.5, 95% CI = 6.1-38.7) than euandrogenemic women. Hyperandrogenemic women (HA) had an OR of 2.4 (95% CI = 1.0-6.2) for elevated SBP and an OR of 2.7 (95% CI = 0.8-8.8) for elevated DBP, independent of age and ovulatory status. Obese HA had an OR of 4.7 (95% CI = 2.3-10.4) for elevated SBP and an OR of 2.9 (95% CI = 1.9-9.9) for elevated DBP. In conclusion, T is associated with an increased risk for obesity and central adiposity. T predicts BP elevation independent of age and ovulatory status. There was a synergistic relationship between obesity and androgens in their affect on BP.

publication date

  • August 1, 1999

Research

keywords

  • Androgens
  • Blood Pressure
  • Hyperandrogenism
  • Ovulation

Identity

Scopus Document Identifier

  • 0032832376

Digital Object Identifier (DOI)

  • 10.1016/s0895-7061(99)00048-5

PubMed ID

  • 10480469

Additional Document Info

volume

  • 12

issue

  • 8 Pt 1