Fibro-osseous lesions of the central nervous system: report of four cases and literature review. Review uri icon

Overview

abstract

  • Fibro-osseous lesions, also reported as calcifying pseudoneoplasms of the neural axis, are uncommon lesions of the CNS. We report four additional cases: two extraaxial and two intraaxial, in patients ages 33, 47, 49, and 59 years at presentation. Fibro-osseous lesions involving the CNS demonstrate variable proportions of fibrous stroma, bone, palisading spindle to epithelioid to multinucleated cells in association with a highly distinctive, perhaps pathognomonic, chondromyxoid-like matrix often distributed in a nodular pattern. This histopathologically distinctive lesion can be seen in many regions of the neuraxis, often with a dural association, and most commonly along the vertebral column. It appears to be a slow-growing lesion and, with wide excision, the prognosis is excellent. The etiology remains unclear, but the preponderance of data favors a reactive rather than neoplastic process. If this putative pseudotumor is not recognized histopathologically, a neoplastic or infectious differential might result in inappropriate investigations and potentially harmful therapies.

publication date

  • October 1, 1999

Research

keywords

  • Calcinosis
  • Central Nervous System Diseases
  • Granuloma

Identity

Scopus Document Identifier

  • 0032851402

Digital Object Identifier (DOI)

  • 10.1097/00000478-199910000-00013

PubMed ID

  • 10524529

Additional Document Info

volume

  • 23

issue

  • 10