Role of potassium channels in the central neurogenic neuroprotection elicited by cerebellar stimulation in rat. Academic Article uri icon

Overview

abstract

  • Electrical stimulation of the cerebellar fastigial nucleus (FN) in spontaneously hypertensive (SHR), Wistar-Kyoto (WKY) and Fisher rats reduced, by approximately 50%, the infarctions produced by occlusion of the middle cerebral artery. Blockade of ATP-dependent potassium (K-ATP) channels with glibenclamide (i.c.v.) abolished salvage only in the SHR rat. While blockade of K-ATP channels failed to abolish salvage in WKY and Fisher rats, participation of potassium channels in neurogenic neuroprotection cannot be excluded.

publication date

  • September 25, 1999

Research

keywords

  • Cerebellar Nuclei
  • Cerebral Infarction
  • Electric Stimulation
  • Glyburide
  • Potassium Channels

Identity

Scopus Document Identifier

  • 0032826128

Digital Object Identifier (DOI)

  • 10.1016/s0006-8993(99)01871-5

PubMed ID

  • 10526150

Additional Document Info

volume

  • 842

issue

  • 2