The induction of skeletal muscle hypertrophy by a ski transgene is promoter-dependent. Academic Article uri icon

Overview

abstract

  • The chicken c-ski gene expresses at least three alternatively spliced messages. Transgenic mice expressing proteins from cDNA corresponding to two of these messages (FB27 and FB29) under the control of a murine sarcoma virus (MSV) long terminal repeat (LTR) express the transgene in skeletal muscle and develop a muscular phenotype. Both a biologically active form of c-ski and the MSV LTR are required for the development of the muscular phenotype. The normal c-ski gene linked to two other tissue-specific promoters failed to induce muscle growth in transgenic mice, as did an inactive mutant of c-ski expressed under the control of the MSV LTR.

publication date

  • January 4, 2000

Research

keywords

  • DNA-Binding Proteins
  • Hypertrophy
  • Muscle, Skeletal
  • Promoter Regions, Genetic
  • Proto-Oncogene Proteins

Identity

Scopus Document Identifier

  • 0033992002

Digital Object Identifier (DOI)

  • 10.1016/s0378-1119(99)00461-8

PubMed ID

  • 10607904

Additional Document Info

volume

  • 241

issue

  • 1