Inhibition of intestinal tumors by curcumin is associated with changes in the intestinal immune cell profile. Academic Article uri icon

Overview

abstract

  • BACKGROUND: The C57BL/6J-Min/+ (Min/+) mouse bears a germline mutation in Apc and is therefore a model for familial adenomatous polyposis and sporadic colorectal cancer. Min/+ intestinal mucosa exhibits a marked tendency for spontaneous adenoma formation. Curcumin is a phenolic antioxidant known for its antitumor and immune modulatory functions in vitro. Curcumin prevents adenoma formation in Min/+ mice, through a mechanism that may be related to its immunomodulatory properties. MATERIALS AND METHODS: To study the relationship between intestinal immunity and curcumin-induced antitumor response, we used immunohistochemistry to characterize the effect of curcumin treatment on resident intestinal immune effector cells in Min/+ mice. RESULTS/CONCLUSION: These results show that mucosal CD4(+) T cells and B cells increase in animals treated with curcumin, suggesting that curcumin modulates lymphocyte-mediated immune functions.

publication date

  • April 1, 2000

Research

keywords

  • Antineoplastic Agents
  • Curcumin
  • Immune System
  • Intestinal Mucosa
  • Intestinal Neoplasms
  • Intestines

Identity

Scopus Document Identifier

  • 0034113598

Digital Object Identifier (DOI)

  • 10.1006/jsre.2000.5826

PubMed ID

  • 10729246

Additional Document Info

volume

  • 89

issue

  • 2