Prostate-specific membrane antigen (PSMA)-specific monoclonal antibodies in the treatment of prostate and other cancers. Review uri icon

Overview

abstract

  • Prostate-specific membrane antigen (PSMA) is a cell surface glycoprotein that is expressed by prostate epithelial cells. PSMA-specific monoclonal antibodies have been utilized to characterize the biologic function and in vivo biodistribution of PSMA. PSMA is an attractive target protein for monoclonal antibody directed imaging or therapeutics for prostate cancer since its expression is relatively restricted to prostate epithelial cells and is over-expressed in prostate cancer, including in advanced stages. Currently, clinical usage of PSMA specific monoclonal antibodies has been limited to diagnostic immunohistochemistry and imaging of patients with prostate cancer. Novel applications for these antibodies will be discussed.

publication date

  • January 1, 1999

Research

keywords

  • Antibodies, Monoclonal
  • Antigens, Surface
  • Carboxypeptidases
  • Neoplasms
  • Prostatic Neoplasms

Identity

Scopus Document Identifier

  • 0033511652

Digital Object Identifier (DOI)

  • 10.1023/a:1006308826967

PubMed ID

  • 10855791

Additional Document Info

volume

  • 18

issue

  • 4