Synthesis and evaluation of geldanamycin-testosterone hybrids. Academic Article uri icon

Overview

abstract

  • Geldanamycin (GDM) binds to the Hsp90 chaperone protein resulting in the degradation of several important signaling proteins. A series of GDM-testosterone linked hybrids has been synthesized and evaluated for activity against prostate cancer cell lines. The hybrid with the greatest activity exhibits potent and selective cytotoxicity against prostate cancer cells containing the androgen receptor.

publication date

  • June 5, 2000

Research

keywords

  • Antineoplastic Agents
  • Quinones
  • Testosterone

Identity

Scopus Document Identifier

  • 0034608532

Digital Object Identifier (DOI)

  • 10.1016/s0960-894x(00)00208-0

PubMed ID

  • 10866406

Additional Document Info

volume

  • 10

issue

  • 11