BCL-6 regulates chemokine gene transcription in macrophages. Academic Article uri icon

Overview

abstract

  • The transcriptional repressor protein BCL-6, implicated in the pathogenesis of B cell lymphoma, regulates lymphocyte differentiation and inflammation. We investigated the mechanism for the T helper cell subset 2 (TH2)-type inflammation that occurs in BCL-6-/- mice. Using chimeric mice we found that the TH2-type inflammation is dependent upon nonlymphoid cells. We identified three chemokines, MCP-1, MCP-3 and MRP-1, which are negatively regulated by BCL-6 in macrophages. Promoter analysis revealed that BCL-6 is a potent repressor of MCP-1 transcription. Our results provide a mechanism for the regulation of TH2-type inflammation by BCL-6 and link TH2 differentiation to innate immunity.

publication date

  • September 1, 2000

Research

keywords

  • Chemokines
  • Chemokines, CC
  • Cytokines
  • DNA-Binding Proteins
  • Gene Expression Regulation
  • Macrophages
  • Proto-Oncogene Proteins
  • Transcription Factors
  • Transcription, Genetic

Identity

Scopus Document Identifier

  • 0034278508

Digital Object Identifier (DOI)

  • 10.1038/79749

PubMed ID

  • 10973278

Additional Document Info

volume

  • 1

issue

  • 3