Hormone replacement therapy and 24-hour blood pressure profile of postmenopausal women. Academic Article uri icon

Overview

abstract

  • Menopause is associated with an increase in blood pressure (BP) and a decrease in physiologic nocturnal BP fall. These factors may play a role in the increased risk of cardiovascular events after menopause. Some studies indicate that transdermal estrogen replacement therapy may help restore the 24-h BP profile, but data on the effect of oral conjugated estrogens are lacking. We compared 24-h ambulatory BP profiles of 42 postmenopausal women not receiving hormone replacement therapy (HRT) and 20 women receiving HRT. HRT was associated with a significant increase in the proportion of dippers (50% in women not receiving HRT and 80% in women receiving HRT, P = .048). Increase in nocturnal dipping may account, in part, for the beneficial cardiovascular effects of HRT.

publication date

  • September 1, 2000

Research

keywords

  • Blood Pressure
  • Circadian Rhythm
  • Estrogen Replacement Therapy
  • Postmenopause

Identity

Scopus Document Identifier

  • 0033850975

Digital Object Identifier (DOI)

  • 10.1016/s0895-7061(00)00284-3

PubMed ID

  • 10981557

Additional Document Info

volume

  • 13

issue

  • 9