Efficacy of the ganciclovir implant in the setting of silicone oil vitreous substitute. Academic Article uri icon

Overview

abstract

  • OBJECTIVE: To evaluate the efficacy of the ganciclovir implant in the setting of silicone oil vitreous substitute. MATERIALS AND METHODS: The authors retrospectively reviewed the charts of 19 patients with cytomegalovirus retinitis who had both a ganciclovir implant and silicone oil vitreous substitute. None of the patients was receiving highly active antiretroviral therapy during the study period. Kaplan-Meier analysis was used to evaluate time to progression in eyes with the ganciclovir implant and silicone oil. RESULTS: In all eyes, the ganciclovir device implantation preceded or coincided with silicone injection. Kaplan-Meier analysis revealed that time to 25% failure from the date of the presence of both the implant and oil was 129 days. Time to 25% failure from the date of ganciclovir device implantation was 179 days. CONCLUSIONS: These results compare favorably with conventional treatment. The ganciclovir implant can be a useful treatment modality in eyes with silicone oil.

publication date

  • January 1, 2000

Research

keywords

  • Antiviral Agents
  • Cytomegalovirus Retinitis
  • Ganciclovir
  • Retinal Detachment
  • Silicone Oils

Identity

Scopus Document Identifier

  • 0034537366

Digital Object Identifier (DOI)

  • 10.1097/00006982-200009000-00014

PubMed ID

  • 11039428

Additional Document Info

volume

  • 20

issue

  • 5