Th1 and Th2 cytokines in a patient with Evans' syndrome and profound lymphopenia. uri icon

Overview

abstract

  • A case of Evans' syndrome with IgM deficiency and lymphopenia was studied before and after splenectomy. The lymphopenia was as a result of profound reduction of CD4 and CD8 cells. Study of cytokine secretion before splenectomy revealed a spontaneous Th1- and Th2-type cytokine production, and complete suppression of transforming growth factor (TGF)-beta. After splenectomy, the patient achieved clinical remission, the natural killer (NK) cell number increased and the pattern of cytokine production showed normalization of interleukin (IL)-2, IL-4, IL-10, TGF-beta and abolition of interferon (IFN)-gamma production. We conclude that splenectomy had a beneficial effect owing to an increase in NK cells and an associated increase in TGF-beta production.

publication date

  • September 1, 2000

Research

keywords

  • Anemia, Hemolytic, Autoimmune
  • Cytokines
  • Immunoglobulin M
  • Lymphopenia
  • Purpura, Thrombocytopenic, Idiopathic
  • Th1 Cells
  • Th2 Cells

Identity

Scopus Document Identifier

  • 0033761375

Digital Object Identifier (DOI)

  • 10.1046/j.1365-2141.2000.02296.x

PubMed ID

  • 11054090

Additional Document Info

volume

  • 110

issue

  • 4