Hypoxic modulation of striatal lesions induced by administration of endothelin-1. Academic Article uri icon

Overview

abstract

  • Levels of endothelin-1 (ET-1), a potent endogenous vasoconstrictor, are elevated in plasma and cerebrospinal fluid (CSF) following cerebral ischemia and reperfusion injury. The present study sought insight into the potential differential vasoactive effects on the cerebral vasculature and resultant neural damage of ET-1 during normoxic vs. ischemic conditions and upon reperfusion. Under normoxic conditions, intrastriatal stereotaxic injection of exogenous ET-1 (40 pmol) induced a significant (P<0.05) reduction (

publication date

  • November 10, 2000

Research

keywords

  • Corpus Striatum
  • Endothelin-1
  • Hypoxia

Identity

Scopus Document Identifier

  • 0034634496

Digital Object Identifier (DOI)

  • 10.1016/s0006-8993(00)02884-5

PubMed ID

  • 11063987

Additional Document Info

volume

  • 883

issue

  • 1