Active tuberculosis in individuals infected with human immunodeficiency virus after isoniazid prophylaxis. Academic Article uri icon

Overview

abstract

  • A review was conducted in Haiti to determine the timing and outcome of active tuberculosis (TB) in human immunodeficiency virus (HIV)-positive patients who had previously received isoniazid (INH) prophylaxis. Of 1005 HIV-seropositive patients who completed INH prophylaxis, 14 (1.4%) subsequently had active TB diagnosed. The median interval between discontinuation of INH prophylaxis and TB diagnosis was 8 months for 6 patients receiving 6 months of INH, 22 months for 5 patients receiving 12-24 months of INH, and 40 months for 3 patients receiving 24-36 months of INH (P = .026). There is a postprophylaxis effect on INH that is dependent upon the duration of therapy.

publication date

  • December 1, 2000

Research

keywords

  • AIDS-Related Opportunistic Infections
  • Antitubercular Agents
  • Isoniazid
  • Tuberculosis, Pulmonary

Identity

Scopus Document Identifier

  • 0034571726

Digital Object Identifier (DOI)

  • 10.1086/317485

PubMed ID

  • 11096020

Additional Document Info

volume

  • 31

issue

  • 6