Laser-capture microdissected schwannian and neuroblastic cells in stage 4 neuroblastomas have the same genetic alterations. Academic Article uri icon

Overview

abstract

  • BACKGROUND: Neuroblastoma (NB) is a heterogeneous tumor composed of mixed populations of neuroblastic, Schwannian, and gangliocytic cells. PROCEDURE: We examined the genetic lineage of Schwannian and neuroblastic cells in stage 4 NB using laser-capture microdissection (LCM) and allelic analysis of microsatellite markers of chromosomes 1p, 11q, and 14q. RESULTS: In 18 out of 19 cases, individual cell types exhibited the same allelotype. CONCLUSION: Our results provide evidence that the majority of Schwannian and neuroblastic cells in stage 4 NB are of neoplastic origin, and support the hypothesis of a tumor stem cell capable of development along multiple lineages.

publication date

  • December 1, 2000

Research

keywords

  • Neuroblastoma
  • Schwann Cells

Identity

Scopus Document Identifier

  • 0033659889

Digital Object Identifier (DOI)

  • 10.1002/1096-911x(20001201)35:6<534::aid-mpo7>3.0.co;2-r

PubMed ID

  • 11107110

Additional Document Info

volume

  • 35

issue

  • 6