Genetic analyses of NFKB1 and OCA-B function: defects in B cells, serum IgM level, and antibody responses in Nfkb1-/-Oca-b-/- mice. Academic Article uri icon

Overview

abstract

  • Defined patterns of gene expression during cell differentiation are likely to be ensured by multiple factors playing redundant roles. By generating mice deficient in both NFKB1 and OCA-B, we show here that the two transcription factors are required for B-1 cell differentiation and serum IgM production. In addition, relative to Nfkb1(-/-) or Oca-b(-/-) mice, the Nfkb1(-/-)Oca-b(-/-) mice show a decrease in conventional B cell frequencies in the spleen and augmented reductions in T-independent and T-dependent Ab responses. These results suggest that NFKB1 and OCA-B play compensatory roles in multiple aspects of B cell differentiation.

publication date

  • December 15, 2000

Research

keywords

  • B-Lymphocytes
  • Ficoll
  • Immunoglobulin M
  • Immunoglobulins
  • NF-kappa B
  • Trans-Activators

Identity

Scopus Document Identifier

  • 0034672062

Digital Object Identifier (DOI)

  • 10.4049/jimmunol.165.12.6825

PubMed ID

  • 11120805

Additional Document Info

volume

  • 165

issue

  • 12