Alterations in plasma transforming growth factor beta in normoalbuminuric type 1 and type 2 diabetic patients. Academic Article uri icon

Overview

abstract

  • Transforming growth factor ss (TGF-ss) is an immunosuppressor. It plays a role in regulating cell proliferation, and deletion of its gene in transgenic mice leads to an autoimmune-like disorder. A role of this cytokine has been proposed in the pathogenesis of type 1 diabetes and probably type 2 diabetes. Previous studies had shown an elevated serum level in type 2 diabetes and a reduced serum level in type 1 diabetes; however, these studies did not address the onset of the alterations of TGF-ss with regard to the duration of diabetes. In this study, we compared the levels of TGF-ss in the serum of groups of patients with type 1 and type 2 diabetes mellitus divided according to the duration of their disease. Twenty-six normoalbuminuric patients with type 1 diabetes and 25 normoalbuminuric patients with type 2 diabetes were divided into three groups according to the onset of their diabetes and were compared with 27 and 15 age-matched normal subjects, respectively. We conclude that in normoalbuminuric patients serum TGF-ss levels increased at the onset of type 2 diabetes and remained elevated throughout the disease; they did not change at the onset of type1 diabetes, however, they started to decrease around 2 yr after the onset of the disease.

publication date

  • December 1, 2000

Research

keywords

  • Albuminuria
  • Diabetes Mellitus, Type 1
  • Diabetes Mellitus, Type 2
  • Transforming Growth Factor beta

Identity

Scopus Document Identifier

  • 0034485840

Digital Object Identifier (DOI)

  • 10.1210/jcem.85.12.7073

PubMed ID

  • 11134127

Additional Document Info

volume

  • 85

issue

  • 12