Further evidence for mitochondrial dysfunction in progressive supranuclear palsy. Academic Article uri icon

Overview

abstract

  • Recent data from our laboratory have identified a role for mitochondrial dysfunction in the pathogenesis of progressive supranuclear palsy (PSP). To extend this finding, we measured key parameters of mitochondrial function in platelet-derived cytoplasmic hybrid (cybrid) cell lines expressing mitochondrial genes from patients with PSP. We observed significant decreases in aconitase activity, cellular ATP levels, and oxygen consumption in PSP cybrids as compared to control cybrids, further suggesting a contributory role of impaired mitochondrial energy metabolism in PSP, possibly due to genetic abnormalities of mitochondrial DNA.

publication date

  • March 1, 2001

Research

keywords

  • Blood Platelets
  • Mitochondria
  • Supranuclear Palsy, Progressive

Identity

Scopus Document Identifier

  • 0035120203

Digital Object Identifier (DOI)

  • 10.1006/exnr.2000.7607

PubMed ID

  • 11170735

Additional Document Info

volume

  • 168

issue

  • 1